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14 条记录 (耗时 0.017 秒)

    Apparatus for decontaminating a liquid surfactant of dioxane
    1.
    发明授权
    Apparatus for decontaminating a liquid surfactant of dioxane 失效
    用于去除二恶烷液体表面活性剂的装置

    公开(公告)号：US5643408A

    公开(公告)日：1997-07-01

    申请号：US442547

    申请日：1995-05-16

    申请人： Yesh P. Sachdeva ,  Richard L. Gabriel

    发明人： Yesh P. Sachdeva ,  Richard L. Gabriel

    IPC分类号： B01D1/00 ,  B01D1/22 ,  B01D1/26 ,  B01D3/34 ,  B01D5/00 ,  C08G65/30 ,  B01D1/14

    CPC分类号： B01D1/22 ,  B01D1/0047 ,  B01D1/26 ,  B01D3/346 ,  B01D5/0084 ,  C08G65/30

    摘要： An apparatus for decontaminating a liquid surfactant of a dioxane having a vapor pressure which is higher than the vapor pressure of the surfactant includes an elevated reservoir for dioxane-contaminated liquid surfactant and an elongate inclined conduit, which has an upper portion for receiving a stream of the contaminated liquid surfactant from the elevated reservoir and a lower portion for discharge of decontaminated liquid surfactant. A heat source is suitable for heating contaminated liquid surfactant in the elongate inclined conduit in an amount sufficient to cause the dioxane contaminant of the liquid surfactant to volatilize, thereby decontaminating the surfactant. A gas source is suitable for directing a gas through the inclined conduit to transport volatilized dioxane out of the conduit. A receptacle is connected to the elongate inclined conduit for receiving the decontaminated liquid surfactant discharged from the inclined conduit.

    摘要翻译： 用于去除具有高于表面活性剂的蒸气压的蒸气压的二恶烷液体表面活性剂的装置包括用于二恶烷污染的液体表面活性剂和细长倾斜导管的升高的储存器，其具有用于接收 来自升高的储存器的污染的液体表面活性剂和用于排出去污液体表面活性剂的下部。 热源适合于加热细长倾斜管道中污染的液体表面活性剂，其量足以使液体表面活性剂的二恶烷污染物挥发，从而净化表面活性剂。 气体源适于引导气体通过倾斜导管，以将挥发的二恶烷输送出导管。 容器连接到细长倾斜导管，用于接收从倾斜导管排出的净化液体表面活性剂。

    Synthesis of nitroalcohol diastereomers
    2.
    发明授权
    Synthesis of nitroalcohol diastereomers 失效
    硝基醇非对映异构体的合成

    公开(公告)号：US06462221B1

    公开(公告)日：2002-10-08

    申请号：US09574620

    申请日：2000-05-19

    申请人： Richard L. Gabriel ,  Adel M. Moussa ,  Sharon Fitzhenry ,  Changhua Liu ,  David A. Swanson ,  Brittany La ,  Salah Zahr ,  Yesh P. Sachdeva ,  Jurjus Jurayj

    发明人： Richard L. Gabriel ,  Adel M. Moussa ,  Sharon Fitzhenry ,  Changhua Liu ,  David A. Swanson ,  Brittany La ,  Salah Zahr ,  Yesh P. Sachdeva ,  Jurjus Jurayj

    IPC分类号： C07C20502

    CPC分类号： C07C213/00 ,  C07B2200/07 ,  Y02P20/55 ,  C07C215/08

    摘要： The present invention relates to a method of preparing a 1-nitro-3-substituted-3-amino-2-propanol diastereomer represented by Structural Formula I: In Structural Formula I, R is an amine protecting group, and R1 is an amino acid side-chain, a protected amino acid side-chain, a substituted or unsubstituted aliphatic group, a substituted or unsubstituted aromatic group, a substituted or unsubstituted heteroaromatic group, a substituted or unsubstituted aralkyl or a substituted or unsubstituted heteroaralkyl group. The method involves contacting a 1-nitro-3-substituted-3-amino-2-propanone with a reducing agent to form a mixture of 1-nitro-3-substituted-3-amino-2-propanol diastereomers. The 1-nitro-3-substituted-3-amino-2-propanol diastereomers are then separated by simulated moving bed chromatography to obtain one or more 1-nitro-3-substituted-3-amino-2-propanol diastereomer.

    摘要翻译： 本发明涉及由结构式I表示的1-硝基-3-取代-3-氨基-2-丙醇非对映体的制备方法：在结构式I中，R是胺保护基，R 1是氨基酸 取代或未取代的芳族基团，取代或未取代的杂芳族基团，取代或未取代的芳烷基或取代或未取代的杂芳烷基。 该方法包括使1-硝基-3-取代-3-氨基-2-丙酮与还原剂接触以形成1-硝基-3-取代-3-氨基-2-丙醇非对映异构体的混合物。 然后通过模拟移动床层析分离1-硝基-3-取代-3-氨基-2-丙醇非对映异构体，得到一种或多种1-硝基-3-取代-3-氨基-2-丙醇非对映异构体。

    Amino acid derivatives and methods of making the same
    3.
    发明授权
    Amino acid derivatives and methods of making the same 失效
    氨基酸衍生物及其制备方法

    公开(公告)号：US06590106B2

    公开(公告)日：2003-07-08

    申请号：US10178180

    申请日：2002-06-21

    申请人： Richard L. Gabriel ,  Jurjus Jurayj

    发明人： Richard L. Gabriel ,  Jurjus Jurayj

    IPC分类号： C07D20712

    CPC分类号： C07C291/10 ,  C07C211/13 ,  C40B40/00 ,  Y02P20/55

    摘要： Disclosed are novel compounds represented by Structural Formula II, IX or XXVIII: R1, R2, and R22 are independently an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. R2 is —NR4R5 or —N+≡C−. Alternatively, R1, and R2, taken together with the methine group to which they are bonded, are a moiety represented by the following structural formula: R3 is —NH2, —OH, —OC(O)H or —OR9. R5, R6 and R7 are independently —H or an amine protecting group. R8 is —H, —OH or —OR8. R9 is an alcohol protecting group. Also disclosed are methods of preparing these compounds.

    摘要翻译： 公开了由结构式II，IX或XXVIII表示的新化合物：R1，R2和R22独立地是脂族基团，取代的脂族基团，芳族基团或取代的芳族基团.R2是-NR4R5或-N + = C- 或者，R1和R2与它们所键合的次甲基一起是由以下结构式表示的部分：R3是-NH2，-OH，-OC（O）H或-OR9R5， R6和R7独立地是-H或胺保护基.R8是-H，-OH或-OR8R9是醇保护基。还公开了制备这些化合物的方法。

    Enzyme activated supports for enantiomeric separations
    4.
    发明授权
    Enzyme activated supports for enantiomeric separations 失效
    用于对映异构体分离的酶活化载体

    公开(公告)号：US06461858B1

    公开(公告)日：2002-10-08

    申请号：US09237334

    申请日：1999-01-26

    申请人： Richard L. Gabriel ,  David A. Swanson

    发明人： Richard L. Gabriel ,  David A. Swanson

    IPC分类号： C07C100

    CPC分类号： C12N9/2462 ,  C12N9/18 ,  C12N11/00 ,  C12N11/08 ,  C12P41/003 ,  C12P41/004 ,  C12P41/006

    摘要： An enzyme is immobilized on a solid support and can react selectively with one enantiomer in an enantiomeric mixture. A methods of using the enzyme immobilized solid support in conjunct with a separating means to separate enantiomeric mixtures is described. An apparatus for separating an enantiomeric mixture using an enzyme immobilized on a solid support is also described.

    摘要翻译： 酶固定在固体支持物上，并且可以与对映体混合物中的一种对映异构体选择性反应。 描述了使用酶固定的固体支持物与分离装置结合以分离对映体混合物的方法。 还描述了使用固定在固体支持物上的酶分离对映体混合物的装置。

    Amino acid derivatives and methods of making the same
    8.
    发明授权
    Amino acid derivatives and methods of making the same 失效
    氨基酸衍生物及其制备方法

    公开(公告)号：US06677459B2

    公开(公告)日：2004-01-13

    申请号：US10427466

    申请日：2003-04-30

    申请人： Richard L. Gabriel ,  Jurjus Jurayj

    发明人： Richard L. Gabriel ,  Jurjus Jurayj

    IPC分类号： C07D23361

    CPC分类号： C07C291/10 ,  C07C211/13 ,  C40B40/00 ,  Y02P20/55

    摘要： Disclosed are novel compounds represented by Structural Formula II, IX or XXVIII: R1, R21, and R22 are independently an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. R2 is —NR4R5 or —N+≡C−. Alternatively, R1 and R2, taken together with the methine group to which they are bonded, are a moiety represented by the following structural formula: R3 is —NH2, —OH, —OC(O)H or —OR9. R5, R6 and R7 are independently —H or an amine protecting group. R8 is —H, —OH or —OR8. R9 is an alcohol protecting group. Also disclosed are methods of preparing these compounds.

    摘要翻译： 公开了由结构式II，IX或XXVIII表示的新化合物：R1，R21和R22独立地是脂族基团，取代的脂族基团，芳族基团或取代的芳族基团.R2是-NR4R5或-N + = C < - 。 或者，R1和R2与它们所键合的次甲基一起是由以下结构式表示的部分：R3是-NH2，-OH，-OC（O）H或-OR9R5，R6 和R7独立地是-H或胺保护基.R 8是-H，-OH或-OR 8 .R 9是醇保护基。还公开了制备这些化合物的方法。

    Stereoselective method for synthesizing dolaphenine
    10.
    发明授权
    Stereoselective method for synthesizing dolaphenine 失效
    用于合成多拉苯苯胺的立体选择性方法

    公开(公告)号：US6020495A

    公开(公告)日：2000-02-01

    申请号：US986834

    申请日：1997-12-08

    申请人： Xiaoyong Sun ,  Yesh P. Sachdeva ,  Donna Kaye Wilson ,  Richard L. Gabriel ,  Siya Ram

    发明人： Xiaoyong Sun ,  Yesh P. Sachdeva ,  Donna Kaye Wilson ,  Richard L. Gabriel ,  Siya Ram

    IPC分类号： C07D277/20

    CPC分类号： C07D277/20

    摘要： The present invention relates to a method for the stereospecific synthesis of an enantiomer of a chiral amine, wherein the chiral amine has the formula R.sup.1 CH(NH.sub.2)R.sup.2. R.sup.1 and R.sup.2 are each independently selected from the group consisting of alkyl, aryl and heterocyclic and radicals. This method is particularly useful for stereospecifically synthesizing S-dolaphenine. The method involves contacting a chiral enantiomer of norephedrine with borane, within an aprotic solvent to form a complex for stereospecifically reducing oximes. The complex is then contacted with an oxime, thereby stereospecifically reducing said oxime to form an enantiomer of a chiral amine.

    摘要翻译： 本发明涉及立体有择合成手性胺对映异构体的方法，其中手性胺具有式R 1 CH（NH 2）R 2。 R 1和R 2各自独立地选自烷基，芳基和杂环基和基团。 该方法对于立体选择性合成S-多拉芬苯特别是特别有用的。 该方法包括在非质子溶剂中使去甲麻黄碱的手性对映异构体与硼烷接触以形成用于立体特异性还原肟的络合物。 然后将络合物与肟接触，由此立体选择性还原所述肟形成手性胺的对映异构体。