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1.发明授权Viral vectors encoding multiple highly homologus non-viral polypeptides and the use of same 有权编码多种高度同源的非病毒多肽的病毒载体及其使用公开(公告)号：US09206440B2
公开(公告)日：2015-12-08
申请号：US13145488
申请日：2010-01-22
申请人： Wen Yang , Richard P. Junghans , Anthony J. Bais
发明人： Wen Yang , Richard P. Junghans , Anthony J. Bais
CPC分类号： C07K16/18 , A61K35/00 , A61K38/00 , A61K48/00 , C07K14/7051 , C07K14/70521 , C07K16/084 , C07K16/40 , C07K2317/622 , C07K2319/70 , C12N7/00 , C12N15/86 , C12N2740/10032 , C12N2740/10052 , C12N2740/13043 , C12N2740/13045 , C12N2810/855 , C12N2810/859
摘要： The present invention relates to compositions and methods for creation of vector nucleic acid sequences (e.g., retroviral nucleic acid sequences) that comprise two or more exogenous nucleic acid sequences that encode highly homologous (e.g., identical) polypeptide sequences, yet wherein at least one of the exogenous nucleic acid sequences has been mutated using degenerate codons for purpose of reducing homology between the two or more exogenous nucleic acid sequences while maintaining the encoded polypeptide sequence. Preferred nucleic acid sequences include those encoding multi-chimeric immune receptor (CIR) genes. Specific nucleic acid sequences of such CIR genes are also disclosed.
摘要翻译： 本发明涉及用于产生载体核酸序列（例如逆转录病毒核酸序列）的组合物和方法，其包含编码高度同源（例如相同）多肽序列的两个或多个外源核酸序列，其中至少一个 使用简并密码子突变外源核酸序列，目的是减少两个或多个外源核酸序列之间的同源性，同时保持编码的多肽序列。 优选的核酸序列包括编码多嵌合免疫受体（CIR）基因的那些。 还公开了这种CIR基因的特异性核酸序列。
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公开(公告)号：US09833480B2
公开(公告)日：2017-12-05
申请号：US13641245
申请日：2011-04-14
IPC分类号： C07K14/705 , A61K35/30 , C07K14/73 , A61K48/00 , A61K38/17
CPC分类号： A61K35/30 , A61K38/1774 , A61K48/00 , C07K14/70514 , C07K2319/03 , C07K2319/33 , C07K2319/735 , C07K2319/74 , C07K2319/90 , C12N2799/027
摘要： The invention features nucleic acid constructs encoding chimeric immune T-cell receptors (CIRs) that are useful for treating HIV in patients. In general, the CIRs contain an extracellular domain which targets HIV or HIV infected cells (e.g., the extracellular domain of CD4), a transmembrane domain, and a cytoplasmic domain for mediating T-cell activation (e.g., CD3 zeta and/or the partial extracellular domain of CD28). The invention also features the use of host cells expressing CIRs in the treatment of HIV.
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公开(公告)号：US20170232070A1
公开(公告)日：2017-08-17
申请号：US15333127
申请日：2016-10-24
申请人： Richard P. Junghans
发明人： Richard P. Junghans
CPC分类号： A61K38/2013 , A61K9/0019 , A61K31/675 , A61K31/7076 , A61K35/17 , A61K38/1774 , A61K39/39558 , A61K45/06 , A61K2035/124 , A61K2039/515 , A61K2300/00 , C07K16/3069 , C07K2317/56 , C07K2317/622 , C07K2319/02 , C07K2319/33
摘要： The present invention includes a method of treating prostate cancer in a human subject in need thereof, comprising administering to the subject an effective amount of a composition comprising interleukin-2 (IL2), and administering to the subject a cell expressing a chimeric antigen receptor (CAR) which specifically binds prostate specific membrane antigen (PSMA), thereby treating prostate cancer in the human subject in need thereof.
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公开(公告)号：US20130183276A1
公开(公告)日：2013-07-18
申请号：US13641245
申请日：2011-04-14
IPC分类号： A61K35/30
CPC分类号： A61K35/30 , A61K38/1774 , A61K48/00 , C07K14/70514 , C07K2319/03 , C07K2319/33 , C07K2319/735 , C07K2319/74 , C07K2319/90 , C12N2799/027
摘要： The invention features nucleic acid constructs encoding chimeric immune T-cell receptors (CIRs) that are useful for treating HIV in patients. In general, the CIRs contain an extracellular domain which targets HIV or HIV infected cells (e.g., the extracellular domain of CD4), a transmembrane domain, and a cytoplasmic domain for mediating T-cell activation (e.g., CD3 zeta and/or the partial extracellular domain of CD28). The invention also features the use of host cells expressing CIRs in the treatment of HIV.
摘要翻译： 本发明的特征在于编码可用于治疗患者HIV的嵌合免疫T细胞受体（CIR）的核酸构建体。 一般来说，CIR包含靶向HIV或HIV感染细胞（例如，CD4的细胞外结构域），跨膜结构域和用于介导T细胞活化的细胞质结构域（例如CD3zeta和/或部分 CD28细胞外结构域）。 本发明还特征在于在治疗HIV中使用表达CIR的宿主细胞。
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5.发明申请Viral Vectors Encoding Multiple Highly Homologus Non-Viral Polypeptides And The Use Of Same 有权编码多个高度同源的非病毒多肽的病毒载体及其使用公开(公告)号：US20120134970A1
公开(公告)日：2012-05-31
申请号：US13145488
申请日：2010-01-22
申请人： Wen Yang , Richard P. Junghans , Anthony J. Bais
发明人： Wen Yang , Richard P. Junghans , Anthony J. Bais
IPC分类号： A61K35/76 , A61P35/00 , C12N5/10 , A61P31/12 , A61P31/18 , A61K35/14 , C12N15/63 , A61P31/00
CPC分类号： C07K16/18 , A61K35/00 , A61K38/00 , A61K48/00 , C07K14/7051 , C07K14/70521 , C07K16/084 , C07K16/40 , C07K2317/622 , C07K2319/70 , C12N7/00 , C12N15/86 , C12N2740/10032 , C12N2740/10052 , C12N2740/13043 , C12N2740/13045 , C12N2810/855 , C12N2810/859
摘要： The present invention relates to compositions and methods for creation of vector nucleic acid sequences (e.g., retroviral nucleic acid sequences) that comprise two or more exogenous nucleic acid sequences that encode highly homologous (e.g., identical) polypeptide sequences, yet wherein at least one of the exogenous nucleic acid sequences has been mutated using degenerate codons for purpose of reducing homology between the two or more exogenous nucleic acid sequences while maintaining the encoded polypeptide sequence. Preferred nucleic acid sequences include those encoding multi-chimeric immune receptor (CIR) genes. Specific nucleic acid sequences of such CIR genes are also disclosed.
摘要翻译： 本发明涉及用于产生载体核酸序列（例如逆转录病毒核酸序列）的组合物和方法，其包含编码高度同源（例如相同）多肽序列的两个或多个外源核酸序列，其中至少一个 使用简并密码子突变外源核酸序列，目的是减少两个或多个外源核酸序列之间的同源性，同时保持编码的多肽序列。 优选的核酸序列包括编码多嵌合免疫受体（CIR）基因的那些。 还公开了这种CIR基因的特异性核酸序列。
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