公开(公告)号：US5099030A

公开(公告)日：1992-03-24

申请号：US722718

申请日：1991-06-27

申请人： Joseph H. Gardner ,  Gerald B. Kasting ,  Thomas L. Cupps ,  Richard S. Echler ,  Thomas W. Gibson ,  Joel I. Shulman

发明人： Joseph H. Gardner ,  Gerald B. Kasting ,  Thomas L. Cupps ,  Richard S. Echler ,  Thomas W. Gibson ,  Joel I. Shulman

IPC分类号： C07C335/12

CPC分类号： C07C335/12

摘要： The present invention relates to beta-aminoethyl-substituted phenyl compounds, especially beta-aminoethoxy-substituted phenyl compounds. The present invention also relates to pharmaceutical compositions comprising a safe and effective amount of a compound of the present invention and a pharmaceutically-acceptable carrier. The present invention further relates to methods for producing analgesia and reducing inflammation, in humans and lower animals, by administering the compounds or compositions of the present invention. In addition, the present invention relates to methods for making compounds of the present invention and intermediates useful in these synthesis methods.

摘要翻译： 本发明涉及β-氨基乙基取代的苯基化合物，特别是β-氨基乙氧基取代的苯基化合物。 本发明还涉及包含安全有效量的本发明化合物和药学上可接受的载体的药物组合物。 本发明还涉及通过施用本发明的化合物或组合物在人类和低等动物中产生止痛和减轻炎症的方法。 此外，本发明涉及制备本发明化合物的方法和可用于这些合成方法的中间体。

公开(公告)号：US5045565A

公开(公告)日：1991-09-03

申请号：US404924

申请日：1989-09-08

申请人： Joseph H. Gardner ,  Gerald B. Kasting ,  Thomas L. Cupps ,  Richard S. Echler ,  Thomas W. Gibson ,  Joel I. Shulman

发明人： Joseph H. Gardner ,  Gerald B. Kasting ,  Thomas L. Cupps ,  Richard S. Echler ,  Thomas W. Gibson ,  Joel I. Shulman

IPC分类号： C07C335/12

CPC分类号： C07C335/12

摘要： The present invention relates to beta-aminoethyl-substituted phenyl compounds, especially beta-aminoethoxy-substituted phenyl compounds. The present invention also relates to pharmaceutical compositions comprising a safe and effective amount of a compound of the present invention and a pharmaceutically-acceptable carrier. The present invention further relates to methods for producing analgesia and reducing inflammation, in humans and lower animals, by administering the compounds or compositions of the present invention. In addition, the present invention relates to methods for making compounds of the present invention and intermediates useful in these synthesis methods.

摘要翻译： 本发明涉及β-氨基乙基取代的苯基化合物，特别是β-氨基乙氧基取代的苯基化合物。 本发明还涉及包含安全有效量的本发明化合物和药学上可接受的载体的药物组合物。 本发明还涉及通过施用本发明的化合物或组合物在人类和低等动物中产生止痛和减轻炎症的方法。 此外，本发明涉及制备本发明化合物的方法和可用于这些合成方法的中间体。

公开(公告)号：US5126487A

公开(公告)日：1992-06-30

申请号：US675384

申请日：1991-03-26

申请人： Thomas W. Gibson ,  Richard S. Echler

发明人： Thomas W. Gibson ,  Richard S. Echler

IPC分类号： C07C45/56 ,  C07C45/46 ,  C07C45/79 ,  C07C45/81 ,  C07C49/835

CPC分类号： C07C49/835 ,  C07C45/46 ,  C07C45/79 ,  C07C45/81

摘要： The subject invention relates to a process for the preparation of 2-alkyl-4-acyl-6-tert-butylphenol compound having the chemical structure: ##STR1## wherein -R is an aliphatic group having a terminally unsaturated moiety selected from --C.tbd.CH and --CH.dbd.C.dbd.CH.sub.2, and R' is selected from saturated, straight, branched or cyclic alkyl having from 1 to about 10 carbon atoms; the 2-alkyl-4-acyl-6-tert-butylphenol compound being produced in a reaction mixture comprising the corresponding 2-alkyl-6-tert-butylphenol: ##STR2## the corresponding carboxylic acid: RCOOH, and trifluoroacetic anhydride.

摘要翻译： 本发明涉及一种制备具有以下化学结构的2-烷基-4-酰基-6-叔丁基苯酚化合物的方法：其中-R是具有选自以下的末端不饱和部分的脂族基团： -C 3 CH或-CH = C = CH 2，R'选自具有1至约10个碳原子的饱和直链，支链或环状烷基; 2-烷基-4-酰基-6-叔丁基苯酚化合物在包含相应的2-烷基-6-叔丁基苯酚的反应混合物中产生：相应的羧酸：RCOOH和三氟乙酸酐。