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公开(公告)号：US06673808B1
公开(公告)日：2004-01-06
申请号：US09673260
申请日：2000-11-22
申请人： Rinta Ibuki , Fumio Shimojo , Satoshi Ueda , Toshihiko Toyoda , Masayuki Yamanaka , Erika Yoshida
发明人： Rinta Ibuki , Fumio Shimojo , Satoshi Ueda , Toshihiko Toyoda , Masayuki Yamanaka , Erika Yoshida
IPC分类号： A61K3144
CPC分类号： A61K9/0014 , A61K31/40 , A61K31/436 , A61K47/08 , A61K47/14 , A61K47/32 , A61K47/38 , C07D498/04 , Y10S514/947
摘要： To provide a pharmaceutical composition comprising a macrolide compound, such as tricyclic compound (I) or its pharmaceutically acceptable salt, a dissolution/absorption promoter, a pharmaceutical base, and optionally a compatibilizing agent and/or a thickener. It is satisfactory in stability and absorption kinetics and/or a low irritation potential.
摘要翻译： 提供包含大环内酯化合物如三环化合物（I）或其药学上可接受的盐，溶解/吸收促进剂，药物基质和任选的相容剂和/或增稠剂的药物组合物。 其稳定性和吸收动力学和/或低刺激潜力令人满意。
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公开(公告)号：US06440458B1
公开(公告)日：2002-08-27
申请号：US09403787
申请日：1999-11-05
申请人： Kazunari Yamashita , Eiji Hashimoto , Yukihiro Nomura , Fumio Shimojo , Shigeki Tamura , Takeo Hirose , Satoshi Ueda , Takashi Saitoh , Rinta Ibuki , Toshio Ideno
发明人： Kazunari Yamashita , Eiji Hashimoto , Yukihiro Nomura , Fumio Shimojo , Shigeki Tamura , Takeo Hirose , Satoshi Ueda , Takashi Saitoh , Rinta Ibuki , Toshio Ideno
IPC分类号： A61K922
CPC分类号： A61K31/453 , A61K9/141 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/1652 , A61K9/4858 , A61K31/407 , A61K31/436
摘要： Providing an oral formulation of a macrolide compound where the dissolution of the macrolide compound is under sustained release; and a sustained-release formulation containing a composition in solid solution, where the macrolide compound is present at an amorphous state in a solid base.
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公开(公告)号：US06586444B2
公开(公告)日：2003-07-01
申请号：US10005645
申请日：2001-12-07
申请人： Rinta Ibuki , Fumio Shimojo , Satoshi Ueda , Toshihiko Toyoda , Masayuki Yamanaka , Erika Yoshida
发明人： Rinta Ibuki , Fumio Shimojo , Satoshi Ueda , Toshihiko Toyoda , Masayuki Yamanaka , Erika Yoshida
IPC分类号： A61K3144
CPC分类号： A61K9/0014 , A61K31/40 , A61K31/436 , A61K47/08 , A61K47/14 , A61K47/32 , A61K47/38 , C07D498/04 , Y10S514/947
摘要： To provide a pharmaceutical composition comprising a macrolide compound, such as tricyclic compound (I) or its pharmaceutically acceptable salt, a dissolution/absorption promoter, a pharmaceutical base, and optionally a compatibilizing agent and/or a thickener. It is satisfactory in stability and absorption kinetics and/or a low irritation potential.
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公开(公告)号：US06387918B1
公开(公告)日：2002-05-14
申请号：US09367698
申请日：1999-08-20
申请人： Masayuki Yamanaka , Fumio Shimojo , Satoshi Ueda , Toshihiko Toyoda , Rinta Ibuki , Norio Ohnishi
发明人： Masayuki Yamanaka , Fumio Shimojo , Satoshi Ueda , Toshihiko Toyoda , Rinta Ibuki , Norio Ohnishi
IPC分类号： A61K3144
CPC分类号： A61K9/0014 , A61K31/407 , A61K31/436 , A61K47/10 , A61K47/14 , A61K47/32
摘要： A pharmaceutical composition comprising a tricyclic compound (I) or its pharmaceutically acceptable salt, an oil substance, a surfactant, a hydrophilic substance, water, and optionally a pH control agent, with enhanced stability, absorbability and/or a low irritation potential, is provided.
摘要翻译： 具有增强的稳定性，吸收性和/或低刺激潜力的三环化合物（I）或其药学上可接受的盐，油性物质，表面活性剂，亲水性物质，水和任选的pH控制剂的药物组合物是 提供。
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公开(公告)号：US20050169993A1
公开(公告)日：2005-08-04
申请号：US11059439
申请日：2005-02-17
申请人： Kazunari Yamashita , Eiji Hashimoto , Yukihiro Nomura , Fumio Shimojo , Shigeki Tamura , Takeo Hirose , Satoshi Ueda , Takashi Saitoh , Rinta Ibuki , Toshio Ideno
发明人： Kazunari Yamashita , Eiji Hashimoto , Yukihiro Nomura , Fumio Shimojo , Shigeki Tamura , Takeo Hirose , Satoshi Ueda , Takashi Saitoh , Rinta Ibuki , Toshio Ideno
IPC分类号： C07H15/04 , A61K20060101 , A61K9/10 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/22 , A61K9/48 , A61K9/52 , A61K31/40 , A61K31/405 , A61K31/407 , A61K31/4353 , A61K31/436 , A61K31/453 , A61K31/706 , A61K47/04 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/40 , A61P31/00 , A61P37/06 , C07D498/18 , G01N33/15 , A61K31/4745
CPC分类号： A61K31/453 , A61K9/141 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/1652 , A61K9/4858 , A61K31/407 , A61K31/436
摘要： A sustained-release formulation is provided comprising a solid dispersion composition comprising a tricyclic compound or a pharmaceutically acceptable salt thereof in a mixture comprising a water-soluble polymer and a water-insoluble polymer, and an excipient.
摘要翻译： 提供了包含在包含水溶性聚合物和水不溶性聚合物和赋形剂的混合物中的包含三环化合物或其药学上可接受的盐的固体分散体组合物的缓释制剂。
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公开(公告)号：US06576259B2
公开(公告)日：2003-06-10
申请号：US09978025
申请日：2001-10-17
申请人： Kazunari Yamashita , Eiji Hashimoto , Yukihiro Nomura , Fumio Shimojo , Shigeki Tamura , Takeo Hirose , Satoshi Ueda , Takashi Saitoh , Rinta Ibuki , Toshio Ideno
发明人： Kazunari Yamashita , Eiji Hashimoto , Yukihiro Nomura , Fumio Shimojo , Shigeki Tamura , Takeo Hirose , Satoshi Ueda , Takashi Saitoh , Rinta Ibuki , Toshio Ideno
IPC分类号： A61K900
CPC分类号： A61K31/453 , A61K9/141 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/1652 , A61K9/4858 , A61K31/407 , A61K31/436
摘要： Sustained release formulation containing tacrolimus or its hydrate is provided. The time (T63.2%) required for 63.2% of the maximum amount of tacrolimus or its hydrate to be dissolved is 0.7 to 15 hours. The time is measured in accordance to the Japanese Pharmacopoeia, the 13-th edition, Dissolution Test, No. 2 (Puddle method, 50 rpm) using an aqueous 0.005% hydroxypropyl cellulose solution. This aqueous test solution is adjusted to pH 4.5, accordingly. The formulation further comprise a solid base which is a water-soluble polymer and/or wax. The formulation is in the form of a powder, fine powder, granule, tablet or capsule. Furthermore, the formulation is administered to a patient once a day for preventing organ or tissue rejection by transplantation or autoimmune diseases.
摘要翻译： 提供含他克莫司或其水合物的缓释制剂。 最高量的他克莫司或其水合物溶解63.2％所需的时间（T63.2％）为0.7〜15小时。 时间根据日本药典，第13版，溶出度试验，第2号（Puddle法，50rpm），使用0.005％羟丙基纤维素水溶液测量。 相应地将该水性测试溶液调节至pH 4.5。 制剂还包含固体碱，其为水溶性聚合物和/或蜡。 制剂为粉末，细粉，颗粒，片剂或胶囊的形式。 此外，该制剂每天一次施用于患者，以通过移植或自身免疫疾病预防器官或组织排斥反应。
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公开(公告)号：US06316473B1
公开(公告)日：2001-11-13
申请号：US09402469
申请日：1999-10-12
申请人： Fumio Shimojo , Sumihisa Kimura , Takeo Hirose , Satoshi Ueda , Rinta Ibuki , Norio Ohnishi
发明人： Fumio Shimojo , Sumihisa Kimura , Takeo Hirose , Satoshi Ueda , Rinta Ibuki , Norio Ohnishi
IPC分类号： A61K3140
CPC分类号： A61K31/436 , A61K9/4866 , A61K47/14 , A61K47/44
摘要： Provided is a medicinal composition having a very satisfactory drug release profile and a very satisfactory drug absorption profile after oral administration characterized by its comprising an insoluble drug and two or more surfactants, at least one of the surfactants having as dissolved therein the insoluble drug and the other surfactant or surfactants.
摘要翻译： 本发明提供一种具有非常令人满意的药物释放特性和口服给药后非常令人满意的药物吸收曲线的药物组合物，其特征在于其包含不溶性药物和两种或更多种表面活性剂，至少一种表面活性剂溶解有不溶性药物和 其他表面活性剂或表面活性剂。
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8.发明授权Pharmaceutical composition for percutaneous drug absorption and percutaneous drug absorption promoter 失效用于经皮药物吸收和经皮药物吸收促进剂的药物组合物
公开(公告)号：US5045553A
公开(公告)日：1991-09-03
申请号：US208071
申请日：1988-06-17
申请人： Yoshio Ueda , Takehisa Hata , Rinta Ibuki , Kazutake Kado , Hiroshi Ishikuro
发明人： Yoshio Ueda , Takehisa Hata , Rinta Ibuki , Kazutake Kado , Hiroshi Ishikuro
IPC分类号： A61K31/455 , A61K9/00 , A61K9/06 , A61K9/08 , A61K9/70 , A61K31/44 , A61K47/00 , A61K47/10 , A61K47/12 , A61P9/08 , A61P9/10 , A61P9/12
CPC分类号： A61K9/7053 , A61K31/44 , A61K47/10 , A61K47/12 , A61K9/0014 , A61K9/7061 , A61K9/7084 , Y10S514/947
摘要： The present invention relates to a pharmaceutical composition for percutaneous drug absorption which comprises 5-isopropyl 3-methyl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and ethanol and/or an unsaturated higher fatty acid and to a composition of matter which comprises ethanol and/or an unsaturated higher fatty acid and is capable of promoting percutaneous absorption of said dihydropyridine compound.
摘要翻译： 一种用于经皮药物吸收的药物组合物，其包括5-异丙基3-氰基-6-甲基-4-（3-硝基苯基）-1,4-二氢吡啶-3,5-二羧酸5-异丙酯和乙醇和/或 不饱和高级脂肪酸。
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公开(公告)号：US08551522B2
公开(公告)日：2013-10-08
申请号：US12265108
申请日：2008-11-05
申请人： Kazunari Yamashita , Eiji Hashimoto , Yukihiro Nomura , Fumio Shimojo , Shigeki Tamura , Takeo Hirose , Satoshi Ueda , Takashi Saitoh , Rinta Ibuki , Toshio Ideno
发明人： Kazunari Yamashita , Eiji Hashimoto , Yukihiro Nomura , Fumio Shimojo , Shigeki Tamura , Takeo Hirose , Satoshi Ueda , Takashi Saitoh , Rinta Ibuki , Toshio Ideno
CPC分类号： A61K31/453 , A61K9/141 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/1652 , A61K9/4858 , A61K31/407 , A61K31/436
摘要： A sustained-release formulation is provided comprising a solid dispersion composition comprising a tricyclic compound or a pharmaceutically acceptable salt thereof in a mixture comprising a water-soluble polymer and a water-insoluble polymer, and an excipient.
摘要翻译： 提供了包含在包含水溶性聚合物和水不溶性聚合物和赋形剂的混合物中的包含三环化合物或其药学上可接受的盐的固体分散体组合物的缓释制剂。
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公开(公告)号：US20090074858A1
公开(公告)日：2009-03-19
申请号：US12265108
申请日：2008-11-05
申请人： Kazunari YAMASHITA , Eiji HASHIMOTO , Yukihiro NOMURA , Fumio SHIMOJO , Shigeki TAMURA , Takeo HIROSE , Satoshi UEDA , Takashi SAITOH , Rinta IBUKI , Toshio IDENO
发明人： Kazunari YAMASHITA , Eiji HASHIMOTO , Yukihiro NOMURA , Fumio SHIMOJO , Shigeki TAMURA , Takeo HIROSE , Satoshi UEDA , Takashi SAITOH , Rinta IBUKI , Toshio IDENO
IPC分类号： A61K9/48 , A61K9/14 , A61K9/20 , A61K31/436
CPC分类号： A61K31/453 , A61K9/141 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/1652 , A61K9/4858 , A61K31/407 , A61K31/436
摘要： A sustained-release formulation is provided comprising a solid dispersion composition comprising a tricyclic compound or a pharmaceutically acceptable salt thereof in a mixture comprising a water-soluble polymer and a water-insoluble polymer and an excipient.
摘要翻译： 提供了包含固体分散体组合物的缓释制剂，其包含三环化合物或其药学上可接受的盐在包含水溶性聚合物和水不溶性聚合物和赋形剂的混合物中。
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