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19 条记录 (耗时 0.019 秒)

    Antibody complexes and methods for immunolabeling
    1.
    发明授权
    Antibody complexes and methods for immunolabeling 有权
    抗体复合物和免疫标记方法

    公开(公告)号：US08323903B2

    公开(公告)日：2012-12-04

    申请号：US10118204

    申请日：2002-04-05

    申请人： Robert A. Archer ,  Joseph M. Beechem ,  David C. Hagen ,  Richard P. Haugland ,  Rosaria P. Haugland

    发明人： Robert A. Archer ,  Joseph M. Beechem ,  David C. Hagen ,  Richard P. Haugland ,  Rosaria P. Haugland

    IPC分类号： G01N33/53

    CPC分类号： B82Y30/00 ,  B82Y5/00 ,  B82Y10/00 ,  G01N33/53 ,  G01N33/58 ,  G01N33/6857

    摘要： The present invention provides novel immunolabeling complexes and certain components of such complexes, as well as methods of preparing and using such complexes, and kits for use in preparing labeling proteins and for immunolabeling. The pre-formed immunolabeling complexes of the invention comprise both a target-binding antibody and a labeling protein that contains covalently attached labels, where the labeling protein binds selectively and with high affinity to a selected region of the target-binding antibody. Novel labeling proteins of the invention include non-antibody peptides and proteins, such as a complex of protein G and a labeled albumin, and monovalent antibody fragments, such as labeled Fab fragments of an anti-Fc antibody. In methods of the invention, the preformed immunolabeling complexes are added to the sample alone or in combination, for purposes of labeling and optionally detecting the target of interest.

    摘要翻译： 本发明提供了新的免疫标记复合物和这些复合物的某些成分，以及制备和使用这些复合物的方法，以及用于制备标记蛋白和免疫标记的试剂盒。 本发明的预先形成的免疫粘附复合物包含靶结合抗体和含有共价连接的标记的标记蛋白，其中所述标记蛋白选择性地结合并且与靶结合抗体的选定区域具有高亲和力。 本发明的新型标记蛋白包括非抗体肽和蛋白质，例如蛋白G和标记的白蛋白的复合物，以及单价抗体片段，例如抗Fc抗体的标记的Fab片段。 在本发明的方法中，为了标记和任选地检测目的靶标，将预先形成的免疫标记复合物单独或组合加入到样品中。

    Benzocycloheptapyrans, compositions, and method of treatment
    2.
    发明授权
    Benzocycloheptapyrans, compositions, and method of treatment 失效
    苯并环庚砜，组合物和治疗方法

    公开(公告)号：US4195024A

    公开(公告)日：1980-03-25

    申请号：US7116

    申请日：1979-01-29

    申请人： Robert A. Archer ,  Moses W. McMillan

    发明人： Robert A. Archer ,  Moses W. McMillan

    IPC分类号： C07D311/94

    CPC分类号： C07D311/94

    摘要： Octahydro and hexahydrobenzo[b]cyclohepta[d]pyrans having the general formula ##STR1## wherein R.sup.1 is hydrogen or alkanoyl, R.sup.2 is alkyl or alkenyl, R.sup.3 is hydrogen or alkyl, and Z is a two carbon alkylene chain which is substituted or unsubstituted and saturated or unsaturated are provided. Pharmaceutical compositions containing such benzocycloheptapyrans, and a method of treating hypertension are disclosed.

    摘要翻译： 具有通式的八氢和六氢苯并[b]环庚三烯并[d]吡喃，其中R1是氢或烷酰基，R2是烷基或烯基，R3是氢或烷基，Z是被取代或未取代的二碳亚烷基链 并提供饱和或不饱和的。 公开了含有这样的苯并环庚酮的药物组合物和治疗高血压的方法。

    Preparation of optically active trans-hexahydrodibenzopyranones
    4.
    发明授权
    Preparation of optically active trans-hexahydrodibenzopyranones 失效
    光学活性反式六氢二苯并吡喃酮的制备

    公开(公告)号：US4075230A

    公开(公告)日：1978-02-21

    申请号：US740507

    申请日：1976-11-10

    申请人： Robert A. Archer ,  William A. Day

    发明人： Robert A. Archer ,  William A. Day

    IPC分类号： A61K31/352 ,  C07D311/80 ,  C07D311/78

    CPC分类号： C07D311/80

    摘要： Reaction of a 5-substituted resorcinol with optically active apoverbenone in the presence of aluminum chloride affords an optically active trans-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-one.

    摘要翻译： 在氯化铝存在下，5-取代间苯二酚与光学活性阿扑巴醌的反应得到光学活性的反式-1-羟基-3-取代-6,6-二甲基-6,6a，7,8,10,10a-六氢 -9H-二苯并[b，d]吡喃-9-酮。

    Backfire bifilar helical antenna
    5.
    发明授权
    Backfire bifilar helical antenna 失效
    背鳍双鱼座天线

    公开(公告)号：US4014028A

    公开(公告)日：1977-03-22

    申请号：US603429

    申请日：1975-08-11

    申请人： John A. Cone ,  Robert A. Archer ,  Edward R. Pacheco ,  Creath E. Peyton

    发明人： John A. Cone ,  Robert A. Archer ,  Edward R. Pacheco ,  Creath E. Peyton

    IPC分类号： H01Q11/08 ,  H01Q1/36

    CPC分类号： H01Q11/08

    摘要： A bifilar helical antenna which will radiate or receive in the backfire mode. The antenna consists of two interlaced helixes fed at the tip. Each helix is fed by a transmission line with energy of equal amplitude but 180.degree. out of phase. Optionally the helixes may be connected to a ground plane at the far end for mechanical stability. For the same reason an insulating right cylinder may be used to support the helixes. The two helixes have such a diameter and such a pitch or pitch distance that the currents flowing from their terminals to the far end are out of phase while the currents flowing in the reverse direction are in phase to provide a fast pseudo wave structure.

    Stereoselective preparation of hexahydro dibenzopyranones and intermediates therefor
    7.
    发明授权
    Stereoselective preparation of hexahydro dibenzopyranones and intermediates therefor 失效
    六氢二苯并吡喃酮及其中间体的立体选择性制备

    公开(公告)号：US4208351A

    公开(公告)日：1980-06-17

    申请号：US30783

    申请日：1979-04-17

    申请人： Robert A. Archer ,  William A. Day

    发明人： Robert A. Archer ,  William A. Day

    IPC分类号： C07D311/80 ,  C07C49/82

    CPC分类号： C07C49/747 ,  C07C45/54 ,  C07D311/80

    摘要： An optically active 4-(4-substituted-2,6-dihydroxyphenyl)-6,6-dimethyl-2-norpinanone is reacted with a protonic acid to provide an optical isomer of a cis-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-one. Reaction of said norpinanone with a Lewis acid provides an optical isomer of trans-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-one. The optically active norpinanones are prepared by reaction of a 5-substituted-resorcinol with an optically active 6,6-dimethyl-2,4-diacetoxy-2-norpinene or an optically active 6,6-dimethyl-2,2-diacetoxy-3-norpinene, which compounds are derived from optically active .beta.-pinenes.

    摘要翻译： 使光学活性的4-（4-取代-2,6-二羟基苯基）-6,6-二甲基-2-降冰片酮与质子酸反应，得到顺式-1-羟基-3-取代-6 ，6-二甲基-6,6a，7,8,10,10a-六氢-9H-二苯并[b，d]吡喃-9-酮。 所述诺丁酮与路易斯酸的反应提供了反式-1-羟基-3-取代-6,6-二甲基-6,6a，7,8,10,10a-六氢-9H-二苯并[b， d]吡喃-9-酮。 通过5-取代的间苯二酚与光学活性的6,6-二甲基-2,4-二乙酰氧基-2-降冰片烯或光学活性的6,6-二甲基-2,2-二乙酰氧基 - 3-降冰片烯，这些化合物衍生自光学活性β-蒎烯。

    Stereoselective preparation of hexahydro dibenzopyranones and intermediates therefor
    8.
    发明授权
    Stereoselective preparation of hexahydro dibenzopyranones and intermediates therefor 失效

    公开(公告)号：US4176233A

    公开(公告)日：1979-11-27

    申请号：US898610

    申请日：1978-04-21

    申请人： Robert A. Archer ,  William A. Day

    发明人： Robert A. Archer ,  William A. Day

    IPC分类号： C07D311/80 ,  C07C69/16

    CPC分类号： C07C69/013 ,  C07C45/54 ,  C07D311/80 ,  C07C2102/42

    摘要： An optically active 4-(4-substituted-2,6-dihydroxyphenyl)-6,6-dimethyl-2-norpinanone is reacted with a protonic acid to provide an optical isomer of a cis-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-one. Reaction of said norpinanone with a Lewis acid provides an optical isomer of trans-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-one. The optically active norpinanones are prepared by reaction of a 5-substituted-resorcinol with an optically active 6,6-dimethyl-2,4-diacetoxy-2-norpinene or an optically active 6,6-dimethyl-2,2-diacetoxy-3-norpinene, which compounds are derived from optically active .beta.-pinenes.

    Stereoselective preparation of hexahydro dibenzopyranones and intermediates therefor
    10.
    发明授权
    Stereoselective preparation of hexahydro dibenzopyranones and intermediates therefor 失效
    六氢二苯并吡喃酮及其中间体的立体选择性制备

    公开(公告)号：US4102902A

    公开(公告)日：1978-07-25

    申请号：US740502

    申请日：1976-11-10

    申请人： Robert A. Archer ,  William A. Day

    发明人： Robert A. Archer ,  William A. Day

    IPC分类号： C07C69/12 ,  A61K31/352 ,  C07C45/00 ,  C07C49/747 ,  C07C67/00 ,  C07C69/14 ,  C07C69/16 ,  C07D311/80

    CPC分类号： C07C49/747 ,  C07C45/54 ,  C07D311/80

    摘要： An optically active 4-(4-substituted-2,6-dihydroxyphenyl)-6,6-dimethyl-2-norpinanone is reacted with a protonic acid to provide an optical isomer of a cis-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-one. Reaction of said norpinanone with a Lewis acid provides an optical isomer of trans-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-one. The optically active norpinanones are prepared by reaction of a 5-substituted-resorcinol with an optically active 6,6-dimethyl-2,4-diacetoxy-2-norpinene or an optically active 6,6-dimethyl-2,2-diacetoxy-3-norpinene, which compounds are derived from optically active .beta.-pinenes.

    摘要翻译： 使光学活性的4-（4-取代-2,6-二羟基苯基）-6,6-二甲基-2-降冰片酮与质子酸反应，得到顺式-1-羟基-3-取代-6 ，6-二甲基-6,6a，7,8,10,10a-六氢-9H-二苯并[b，d]吡喃-9-酮。 所述诺丁酮与路易斯酸的反应提供了反式-1-羟基-3-取代-6,6-二甲基-6,6a，7,8,10,10a-六氢-9H-二苯并[b， d]吡喃-9-酮。 通过5-取代的间苯二酚与光学活性的6,6-二甲基-2,4-二乙酰氧基-2-降冰片烯或光学活性的6,6-二甲基-2,2-二乙酰氧基 - 3-降冰片烯，这些化合物衍生自光学活性β-蒎烯。