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公开(公告)号：US08324148B2
公开(公告)日：2012-12-04
申请号：US10319316
申请日：2002-12-13
Applicant: Jack J. Hawiger , Daniel Robinson , Ruth Ann Veach , Xue Yan Liu , Danya Liu , Sheila Downs , Robert D. Collins , Yao-Zhong Lin
Inventor： Jack J. Hawiger , Daniel Robinson , Ruth Ann Veach , Xue Yan Liu , Danya Liu , Sheila Downs , Robert D. Collins , Yao-Zhong Lin
CPC classification number: C12N15/87 , A61K38/1709 , A61K39/00 , A61K47/62 , A61K47/65 , C07K14/475 , C07K14/50 , C07K14/501 , C07K2319/09 , C07K2319/10 , C07K2319/40 , C12N15/625 , Y02A50/403
Abstract: The present invention relates to the delivery of biologically active molecules, such as peptides, nucleic acids and therapeutic agents, into the interior of cells by administering to the cells a complex comprising the molecule linked to an importation competent signal peptide. Such delivery can be utilized for purposes such as peptide therapy, gene transfer, and antisense therapy to regulate and/or eradicate systemic inflammatory response syndromes such as endotoxic shock.
Abstract translation: 本发明涉及将生物活性分子例如肽，核酸和治疗剂递送到细胞内部，通过向细胞施用包含与导入感受态信号肽连接的分子的复合物。 这种递送可用于诸如肽治疗，基因转移和反义治疗等目的，以调节和/或根除全身性炎症反应综合征，如内毒素性休克。
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公开(公告)号：US08043576B2
公开(公告)日：2011-10-25
申请号：US12689469
申请日：2010-01-19
Applicant: Gerard D Agnew , Robert H Cunningham , Philip D Butler , Robert D Collins
Inventor： Gerard D Agnew , Robert H Cunningham , Philip D Butler , Robert D Collins
IPC: B01J8/02
CPC classification number: H01M8/0631 , B01J10/007 , C01B3/38 , C01B2203/0227 , C01B2203/0277 , C01B2203/066 , C01B2203/0838 , C01B2203/1035 , C01B2203/1241 , H01M2008/1293
Abstract: A reformer module (10) comprises a hollow support member (12) having at least one passage (14) extending longitudinally therethrough. The hollow support member (14) has an external surface (20), a barrier layer (22) arranged on at least a portion of the external surface (20) of the hollow support member (12), a catalyst layer (24) arranged on the barrier layer (22) and a sealing layer (26) arranged on the catalyst layer (24) and the external surface (20) of the hollow support member (12) other than the at least a portion of the external surface of the hollow support member (12). By providing the barrier layer (22) and the catalyst layer (24) on the exterior surface (20) of the hollow support member (12), the distribution of the barrier layer (22) and/or the catalyst layer (24) may be more precisely controlled and thus a non-uniform distribution of barrier layer (22) and/or catalyst layer (24) may be achieved.
Abstract translation: 重整器模块（10）包括具有至少一个纵向延伸通过的通道（14）的中空支撑构件（12）。 中空支撑构件（14）具有外表面（20），布置在中空支撑构件（12）的外表面（20）的至少一部分上的阻挡层（22），布置在中空支撑构件 在所述阻挡层（22）上的密封层（26）和布置在所述催化剂层（24）上的密封层（26）和所述中空支撑构件（12）的外表面（20）之外，所述外表面的至少一部分 中空支撑构件（12）。 通过在中空支撑构件（12）的外表面（20）上设置阻挡层（22）和催化剂层（24），阻挡层（22）和/或催化剂层（24）的分布可以 可以更精确地控制，因此可以实现阻挡层（22）和/或催化剂层（24）的不均匀分布。
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Patent Agency Ranking
公开(公告)号：US07749465B2
公开(公告)日：2010-07-06
申请号：US11312378
申请日：2005-12-21
Applicant: Gerard D. Agnew , Robert H. Cunningham , Philip D. Butler , Robert D. Collins
Inventor： Gerard D. Agnew , Robert H. Cunningham , Philip D. Butler , Robert D. Collins
IPC: B01J8/02
CPC classification number: H01M8/0631 , B01J10/007 , C01B3/38 , C01B2203/0227 , C01B2203/0277 , C01B2203/066 , C01B2203/0838 , C01B2203/1035 , C01B2203/1241 , H01M2008/1293
Abstract: A reformer module (10) comprises a hollow support member (12) having at least one passage (14) extending longitudinally therethrough. The hollow support member (14) has an external surface (20), a barrier layer (22) arranged on at least a portion of the external surface (20) of the hollow support member (12), a catalyst layer (24) arranged on the barrier layer (22) and a sealing layer (26) arranged on the catalyst layer (24) and the external surface (20) of the hollow support member (12) other than the at least a portion of the external surface of the hollow support member (12). By providing the barrier layer (22) and the catalyst layer (24) on the exterior surface (20) of the hollow support member (12), the distribution of the barrier layer (22) and/or the catalyst layer (24) may be more precisely controlled and thus a non-uniform distribution of barrier layer (22) and/or catalyst layer (24) may be achieved.
Abstract translation: 重整器模块（10）包括具有至少一个纵向延伸通过的通道（14）的中空支撑构件（12）。 中空支撑构件（14）具有外表面（20），布置在中空支撑构件（12）的外表面（20）的至少一部分上的阻挡层（22），布置在中空支撑构件 在所述阻挡层（22）上的密封层（26）和布置在所述催化剂层（24）上的密封层（26）和所述中空支撑构件（12）的外表面（20）之外，所述外表面的至少一部分 中空支撑构件（12）。 通过在中空支撑构件（12）的外表面（20）上设置阻挡层（22）和催化剂层（24），阻挡层（22）和/或催化剂层（24）的分布可以 可以更精确地控制，因此可以实现阻挡层（22）和/或催化剂层（24）的不均匀分布。
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公开(公告)号：US06495518B1
公开(公告)日：2002-12-17
申请号：US09450071
申请日：1999-11-29
Applicant: Jack J. Hawiger , Daniel Robinson , Ruth Ann Veach , Xue Yan Liu , Danya Liu , Sheila Timmons , Robert D. Collins
Inventor： Jack J. Hawiger , Daniel Robinson , Ruth Ann Veach , Xue Yan Liu , Danya Liu , Sheila Timmons , Robert D. Collins
IPC: A61K3816
CPC classification number: C12N15/87 , A61K38/1709 , A61K39/00 , A61K47/62 , A61K47/65 , C07K14/475 , C07K14/50 , C07K14/501 , C07K2319/09 , C07K2319/10 , C07K2319/40 , C12N15/625 , Y02A50/403
Abstract: The present invention relates to the delivery of biologically active molecules, such as peptides, nucleic acids and therapeutic agents, into the interior of cells by administering to the cells a complex comprising the molecule linked to an importation competent signal peptide. Such delivery can be utilized for purposes such as peptide therapy, gene transfer, and antisense therapy to regulate and/or eradicate systemic inflammatory response syndromes such as endotoxic shock.
Abstract translation: 本发明涉及将生物活性分子例如肽，核酸和治疗剂递送到细胞内部，通过向细胞施用包含与导入感受态信号肽连接的分子的复合物。 这种递送可用于诸如肽治疗，基因转移和反义治疗等目的，以调节和/或根除全身性炎症反应综合征，如内毒素性休克。
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公开(公告)号：US5458857A
公开(公告)日：1995-10-17
申请号：US155642
申请日：1993-11-22
Applicant: Robert D. Collins , Michael J. Oakley
Inventor： Robert D. Collins , Michael J. Oakley
CPC classification number: B01J8/0496 , B01J8/0449 , B01J8/0492 , C01B3/382 , C01B3/48 , B01J2208/00203 , B01J2208/00309 , B01J2208/00495 , B01J2208/0053 , C01B2203/0244 , C01B2203/0261 , C01B2203/0283 , C01B2203/045 , C01B2203/0485 , C01B2203/066 , C01B2203/0811 , C01B2203/0822 , C01B2203/0844 , C01B2203/0883 , C01B2203/0894 , C01B2203/1011 , C01B2203/1052 , C01B2203/107 , C01B2203/1076 , C01B2203/1205 , C01B2203/1241 , C01B2203/127 , C01B2203/1276 , C01B2203/1294 , C01B2203/142 , C01B2203/1604 , C01B2203/1614 , C01B2203/1638 , C01B2203/82 , C01B2203/84 , Y02P20/128 , Y02P20/52
Abstract: A combined reformer and shift reactor comprises a cylindrical reforming chamber arranged within and on the axis of a cylindrical vessel. An annular steam generator is arranged within, and coaxially with, the vessel. The steam generator is arranged around the reforming chamber. A plurality of shift reactors extend axially, with respect to the vessel, through the steam generator. Methane and steam are supplied via helically coiled pipe to the reforming chamber and air is supplied via helically coiled pipe. The methane and steam mixture and air flowing through the pipes are preheated by the reforming chamber product gases flowing in annular passage. The shift reactors convert carbon monoxide and water in the product gases to carbon dioxide and hydrogen and the heat produced is transferred to the water in the steam generator to produce steam.
Abstract translation: 组合的重整器和换档反应器包括布置在圆柱形容器内部和轴上的圆柱形重整室。 环形蒸汽发生器布置在容器的内部并与其同轴。 蒸汽发生器布置在重整室周围。 多个换档反应器相对于容器轴向延伸通过蒸汽发生器。 甲烷和蒸汽通过螺旋盘管提供给重整室，空气通过螺旋盘管供应。 流经管道的甲烷和蒸汽混合物和空气通过在环形通道中流动的重整室产物气体预热。 变换反应器将产物气体中的一氧化碳和水转化为二氧化碳和氢气，并将产生的热量转移到蒸汽发生器中的水以产生蒸汽。
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公开(公告)号：US20100135872A1
公开(公告)日：2010-06-03
申请号：US12689469
申请日：2010-01-19
Applicant: Gerard D Agnew , Robert H Cunningham , Philip D Butler , Robert D Collins
Inventor： Gerard D Agnew , Robert H Cunningham , Philip D Butler , Robert D Collins
IPC: B01J8/02
CPC classification number: H01M8/0631 , B01J10/007 , C01B3/38 , C01B2203/0227 , C01B2203/0277 , C01B2203/066 , C01B2203/0838 , C01B2203/1035 , C01B2203/1241 , H01M2008/1293
Abstract: A reformer module (10) comprises a hollow support member (12) having at least one passage (14) extending longitudinally therethrough. The hollow support member (14) has an external surface (20), a barrier layer (22) arranged on at least a portion of the external surface (20) of the hollow support member (12), a catalyst layer (24) arranged on the barrier layer (22) and a sealing layer (26) arranged on the catalyst layer (24) and the external surface (20) of the hollow support member (12) other than the at least a portion of the external surface of the hollow support member (12). By providing the barrier layer (22) and the catalyst layer (24) on the exterior surface (20) of the hollow support member (12), the distribution of the barrier layer (22) and/or the catalyst layer (24) may be more precisely controlled and thus a non-uniform distribution of barrier layer (22) and/or catalyst layer (24) may be achieved.
Abstract translation: 重整器模块（10）包括具有至少一个纵向延伸通过的通道（14）的中空支撑构件（12）。 中空支撑构件（14）具有外表面（20），布置在中空支撑构件（12）的外表面（20）的至少一部分上的阻挡层（22），布置在中空支撑构件 在所述阻挡层（22）上的密封层（26）和布置在所述催化剂层（24）上的密封层（26）和所述中空支撑构件（12）的外表面（20）之外，所述外表面的至少一部分 中空支撑构件（12）。 通过在中空支撑构件（12）的外表面（20）上设置阻挡层（22）和催化剂层（24），阻挡层（22）和/或催化剂层（24）的分布可以 可以更精确地控制，因此可以实现阻挡层（22）和/或催化剂层（24）的不均匀分布。
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7.发明授权Cell permeable peptides for inhibition of inflammatory reactions and methods of use 失效用于抑制炎症反应的细胞可渗透肽和使用方法公开(公告)号：US07553929B2
公开(公告)日：2009-06-30
申请号：US10148457
申请日：2000-11-29
Applicant: Jack J. Hawiger , Daniel Robinson , Ruth Ann Veach , Xue Yan Liu , Danya Liu , Sheila Downs , Robert D. Collins , Yao-Zhong Lin
Inventor： Jack J. Hawiger , Daniel Robinson , Ruth Ann Veach , Xue Yan Liu , Danya Liu , Sheila Downs , Robert D. Collins , Yao-Zhong Lin
CPC classification number: C12N15/87 , A61K38/1709 , A61K39/00 , A61K47/62 , A61K47/65 , C07K14/475 , C07K14/50 , C07K14/501 , C07K2319/09 , C07K2319/10 , C07K2319/40 , C12N15/625
Abstract: The present invention relates to the delivery of biologically active molecules, such as peptides, into the interior of cells by administering to the cells a complex comprising the molecule linked to an importation competent signal peptide. Such delivery can be utilized, for example, to treat and/or prevent inflammatory conditions, e.g., but not limited to, systemic inflammatory reactions such as endotoxic shock, localized inflammatory reactions such as inflammatory skin diseases and conditions, and inflammatory diseases such as autoimmune diseases.
Abstract translation: 本发明涉及通过向细胞施用包含与导入感受态信号肽连接的分子的复合物将生物活性分子例如肽递送到细胞内部。 这种递送可用于例如治疗和/或预防炎性病症，例如但不限于全身性炎症反应，例如内毒素性休克，局部炎症反应如炎性皮肤病和病症，以及炎性疾病如自身免疫 疾病
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