公开(公告)号：US4108994A

公开(公告)日：1978-08-22

申请号：US721370

申请日：1976-09-08

申请人： Andre Poittevin ,  Pierre Henri Derible ,  Robert Fournex

发明人： Andre Poittevin ,  Pierre Henri Derible ,  Robert Fournex

IPC分类号： C07D277/22 ,  C07D277/28 ,  C07D487/18 ,  C07D277/38 ,  A61K31/425

CPC分类号： C07D277/22 ,  C07D277/28 ,  Y10S514/866

摘要： A 5-thiazole-methane-amine selected from the group consisting of (1) compounds having the formula ##STR1## wherein R.sub.1 represents an alkyl having from 1 to 6 carbon atoms and R.sub.2 and R.sub.3 represent members selected from the group consisting of hydrogen, alkyl having from 1 to 6 carbon atoms, hydroxyalkyl having 1 to 6 carbon atoms, and, taken together, alkylene having up to 5 carbon atoms, azaalkylene having up to 4 carbon atoms, alkylalkylene having up to 5 carbon atoms in the alkylene and 1 to 4 carbon atoms in the alkyl, and alkylazaalkylene having up to 4 carbon atoms in the azaalkylene and 1 to 4 carbon atoms in the alkyl which may be in any position, and (2) its acid addition salts with non-toxic, pharmaceutically-acceptible acids; as well as processes for the preparation of the compounds and a process for use of the compounds as an antilipolytic agent.

公开(公告)号：US4078076A

公开(公告)日：1978-03-07

申请号：US690010

申请日：1976-05-26

申请人： Francois Clemence ,  Daniel Humbert ,  Robert Fournex

发明人： Francois Clemence ,  Daniel Humbert ,  Robert Fournex

IPC分类号： C07D309/04 ,  C07D309/06 ,  A61K31/35 ,  C07D309/22

CPC分类号： C07D309/04 ,  C07D309/06

摘要： Novel pyranic derivatives of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and cations of alkali metals, alkaline earth metals, aluminum, amines and ammonium R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms and X is selected from the group consisting of hydrogen, chlorine and bromine having hypolipemic activity and reducing the level of total lipids in plasma.

摘要翻译： 其中R选自氢，1至6个碳原子的烷基和碱金属，碱土金属，铝，胺和铵的阳离子的新颖的吡喃衍生物，其中R 1和R 2分别选自 由氢和1-4个碳原子的烷基组成的组，X选自具有降血脂活性的氢，氯和溴，并降低血浆中总脂质的含量。

公开(公告)号：US4436752A

公开(公告)日：1984-03-13

申请号：US368209

申请日：1982-04-14

申请人： Yani Christidis ,  Robert Fournex

发明人： Yani Christidis ,  Robert Fournex

IPC分类号： C07C69/738 ,  A61K31/19 ,  A61K31/215 ,  A61P1/04 ,  C07C51/00 ,  C07C59/90 ,  C07C67/00

CPC分类号： C07C59/90 ,  Y10S514/926 ,  Y10S514/927

摘要： Gastric and gastro-duodenal disorders are treated by administering a compound of formula (I) ##STR1## in which A and B together represent a double bond or else A represents a hydrogen atom and B represents a hydroxy radical, and in which R represents a hydrogen atom or an alkyl radical containing from 1 to 5 carbon atoms, in the various possible stereoisomeric forms, as well as the pharmaceutically acceptable alkali metal, alkaline earth metal or amine salts of the compound of formula (I) in which R represents a hydrogen atom.

摘要翻译： 通过施用式（I）化合物（I），其中A和B一起表示双键或A表示氢原子，B表示羟基，治疗胃和胃十二指肠疾病，其中 R表示氢原子或含有1至5个碳原子的烷基，以各种可能的立体异构形式，以及式（I）化合物的药学上可接受的碱金属，碱土金属或胺盐，其中R 表示氢原子。

公开(公告)号：US4332808A

公开(公告)日：1982-06-01

申请号：US221927

申请日：1980-12-31

申请人： Jacques Guillaume ,  Lucien Nedelec ,  Claude Dumont ,  Robert Fournex

发明人： Jacques Guillaume ,  Lucien Nedelec ,  Claude Dumont ,  Robert Fournex

IPC分类号： C07D401/04 ,  A61K31/44 ,  A61K31/445 ,  C07D401/02

CPC分类号： C07D401/04

摘要： Novel indoles of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms and aralkyl of 7 to 12 carbon atoms, X is selected from the group consisting of hydrogen and alkyl of 1 to 18 carbon atoms, Y is selected from the group consisting of hydrogen and halogen, Z is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, hydroxy alkyl of 1 to 8 carbon atoms, aryloxyalkyl of 7 to 12 carbon atoms, arylalkyl of 7 to 12 carbon atoms optionally substituted with at least one member of the group consisting of halogen, alkoxy of 1 to 4 carbon atoms, alkyl of 1 to 4 carbon atoms, --OH, --CF.sub.3, --OCF.sub.3, --NO.sub.2 and NH.sub.2, cycloalkylalkyl of 4 to 12 carbon atoms, alkenyl of 3 to 8 carbon atoms and alkynyl of 3 to 8 carbon atoms, and a and b may each be hydrogen or form a double bond or a is hydrogen and b is selected from the group consisting of --OH and alkoxy of 1 to 8 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having dopaminergic stimulating properties optionally accompanied with adrenergic and serotoninergic activity and their preparation and novel intermediates.

摘要翻译： 其中R选自氢，1至8个碳原子的烷基和7至12个碳原子的芳烷基的新颖的吲哚，其中R选自氢和1至18的烷基 Y选自氢和卤素，Z选自氢，1至8个碳原子的烷基，1至8个碳原子的羟基烷基，7至12个碳原子的芳氧基烷基， 任选被至少一个卤素，1-4个碳原子的烷氧基，1-4个碳原子的烷基，-OH，-CF 3，-OCF 3，-NO 2和NH 2取代的7-12个碳原子的芳基烷基 4至12个碳原子的环烷基烷基，3至8个碳原子的链烯基和3至8个碳原子的炔基，a和b可各自为氢或形成双键，或a为氢，b选自 的-OH和1至8个碳原子的烷氧基，并且它们是无毒的，药学上可接受的 具有任选伴随肾上腺素能和5-羟色胺能活性的多巴胺能刺激性质的酸加成盐及其制备和新型中间体。

公开(公告)号：US4501740A

公开(公告)日：1985-02-26

申请号：US420791

申请日：1982-09-21

申请人： Francois Clemence ,  Italo Medici ,  Robert Fournex ,  Colette Tournemine

发明人： Francois Clemence ,  Italo Medici ,  Robert Fournex ,  Colette Tournemine

IPC分类号： A61K31/435 ,  A61P9/00 ,  C07D461/00 ,  C07D471/22

CPC分类号： C07D461/00

摘要： Novel 20,21-dinoreburnamenines of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and .dbd.CH.sub.2, the wavy line connecting to the E ring being a single bond when R is hydrogen or alkyl of 1 to 4 carbon atoms or a double bond when R is .dbd.CH.sub.2 and the dotted line being possibly an endo carbon-carbon bond when R is hydrogen or alkyl of 1 to 4 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts in all their possible isomers forms, racemic mixtures and optical isomers having oxygenating and cerebral vasoregulating activity of great value and a novel process and intermediates for their preparation.

摘要翻译： 新型20,21-二辛基ines of <