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公开(公告)号:US10080876B2
公开(公告)日:2018-09-25
申请号:US13060040
申请日:2009-08-20
申请人: Robert I. Tepper , Russell Hirsch , Jason E. Fuller , Jessica L. Duda , Craig Muir , Jeffrey S. Ross , J. Christopher Flaherty
发明人: Robert I. Tepper , Russell Hirsch , Jason E. Fuller , Jessica L. Duda , Craig Muir , Jeffrey S. Ross , J. Christopher Flaherty
CPC分类号: A61M31/002 , A61B5/14532 , A61B5/1455 , A61B5/415 , A61B5/418 , A61B5/4839 , A61M37/0015 , A61M2037/0023 , A61M2037/0061
摘要: Described here are devices, systems, and kits for delivering substances to tissues. The devices generally include one or more chambers (102) and a reservoir (108) within each chamber. The reservoir may locally deliver a microdose amount of a substance to a target tissue. In some variations, a microdose amount is used in early human studies, e.g., before a phase I clinical trial, to evaluate the effect of the substance on a target tissue, or to obtain pharmacokinetic or metabolic data. In other variations, a microdose amount is used to locally treat a medical condition. In yet other variations, a microdose amount is used to locally deliver a contrast agent for a structural or functional imaging procedure. Methods for delivering and retrieving the devices from the target tissue are also described.
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公开(公告)号:US20110230736A1
公开(公告)日:2011-09-22
申请号:US13060040
申请日:2009-08-20
申请人: Robert I. Tepper , Russell Hirsch , Jason E. Fuller , Jessica L. Duda , Craig Muir , Jeffrey S. Ross , J. Christopher Flaherty
发明人: Robert I. Tepper , Russell Hirsch , Jason E. Fuller , Jessica L. Duda , Craig Muir , Jeffrey S. Ross , J. Christopher Flaherty
CPC分类号: A61M31/002 , A61B5/14532 , A61B5/1455 , A61B5/415 , A61B5/418 , A61B5/4839 , A61M37/0015 , A61M2037/0023 , A61M2037/0061
摘要: Described here are devices, systems, and kits for delivering substances to tissues. The devices generally include one or more chambers (102) and a reservoir (108) within each chamber. The reservoir may locally deliver a microdose amount of a substance to a target tissue. In some variations, a microdose amount is used in early human studies, e.g., before a phase I clinical trial, to evaluate the effect of the substance on a target tissue, or to obtain pharmacokinetic or metabolic data. In other variations, a microdose amount is used to locally treat a medical condition. In yet other variations, a microdose amount is used to locally deliver a contrast agent for a structural or functional imaging procedure. Methods for delivering and retrieving the devices from the target tissue are also described.
摘要翻译: 这里描述的是用于将物质输送到组织的装置,系统和试剂盒。 装置通常包括在每个室内的一个或多个室(102)和储存器(108)。 储存器可以局部地将微剂量的物质输送到靶组织。 在一些变化中,微量剂量用于早期人类研究,例如在I期临床试验之前,以评价该物质对靶组织的作用,或获得药代动力学或代谢数据。 在其他变型中,使用微量剂量来局部治疗医疗状况。 在其它变型中,使用微量的量来局部输送用于结构或功能成像过程的造影剂。 还描述了用于从靶组织递送和检索装置的方法。
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公开(公告)号:US08580253B2
公开(公告)日:2013-11-12
申请号:US12513830
申请日:2007-11-06
申请人: Ifat Rubin-Bejerano , Gerald R. Fink , Claudia Abeijon , Danial S. Kohane , Jason E. Fuller , Robert S. Langer
发明人: Ifat Rubin-Bejerano , Gerald R. Fink , Claudia Abeijon , Danial S. Kohane , Jason E. Fuller , Robert S. Langer
IPC分类号: A61K39/395 , A61K38/00
CPC分类号: A61K31/716 , A61K8/73 , A61K36/09 , A61K45/06 , A61Q19/00 , A61K2300/00
摘要: This invention is directed to β-1-6-glucans, compositions and devices comprising the same, and methods of use thereof in modulating immune responses. The β-1-6-glucans of certain embodiments of the invention are enriched for O-acetylated groups and/or conjugated to a solid support or linked to a targeting moiety.
摘要翻译: 本发明涉及β-1-6-葡聚糖,包含其的组合物和装置及其在调节免疫应答中的用途。 本发明的某些实施方案的β-1-6-葡聚糖富含O-乙酰化基团和/或与固体支持物缀合或连接至靶向部分。
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公开(公告)号:US20110045049A1
公开(公告)日:2011-02-24
申请号:US12513830
申请日:2007-11-06
申请人: Ifat Rubin-Bejerano , Gerald R. Fink , Claudia Abeijon , Danial S. Kohane , Jason E. Fuller , Robert S. Langer
发明人: Ifat Rubin-Bejerano , Gerald R. Fink , Claudia Abeijon , Danial S. Kohane , Jason E. Fuller , Robert S. Langer
IPC分类号: A61F2/00 , A61K9/00 , A61F6/08 , A61K39/395 , A61K39/12 , A61K39/02 , A61K39/002 , A61K39/35 , A61K39/00 , C12N5/071 , A61K38/02 , A61K31/716 , C08B37/00 , A61P35/00 , A61P37/02 , A61P37/04 , A61P31/12 , A61P31/04 , A61P33/10 , A61P33/00 , A61P37/06
CPC分类号: A61K31/716 , A61K8/73 , A61K36/09 , A61K45/06 , A61Q19/00 , A61K2300/00
摘要: This invention is directed to β-1-6-glucans, compositions and devices comprising the same, and methods of use thereof in modulating immune responses. The β-1-6-glucans of certain embodiments of the invention are enriched for O-acetylated groups and/or conjugated to a solid support or linked to a targeting moiety.
摘要翻译: 本发明涉及β-葡聚糖,包含其的组合物和装置及其在调节免疫应答中的用途。 本发明某些实施方案的β-葡聚糖富含O-乙酰化基团和/或与固体支持物缀合或与靶向部分连接。
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