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    Geodesic Framework Hub with Strut Holding Mechanism Movable Between Full-Hold and Partial-Hold Positions
    1.
    发明申请
    Geodesic Framework Hub with Strut Holding Mechanism Movable Between Full-Hold and Partial-Hold Positions 审中-公开

    公开(公告)号：US20190154079A1

    公开(公告)日：2019-05-23

    申请号：US15819882

    申请日：2017-11-21

    申请人： Robert Shapiro

    发明人： Robert Shapiro

    IPC分类号： F16C11/06 ,  F16B7/00

    摘要： A hub for interconnecting a plurality struts at a node of geodesic framework features a receiver and a holding mechanism. The receiver has a plurality of receptacles to each receive an end of a respective strut. The holding mechanism is movable between a full-hold position and different partial-hold positions. The full-hold position at least partially obstructs each of the receptacles to block withdrawal of any strut ends already received in the receptacles. Each partial-hold position reveals one of the receptacles to enable insertion or withdrawal of a strut end, while continuing to obstruct all of the other receptacles to prevent inadvertent separation of any previously installed strut. Struts are inserted one-by-one as the holding mechanism is indexed from one partial-hold position to the next, without worry of any preceding strut separating from the hub. A kit with a spacer enables fastening of two hubs together in a multi-layer geodesic framework.

    Small-molecule inhibitors of angiogenin and rnases and in vivo and in vitro methods of using same
    3.
    发明申请
    Small-molecule inhibitors of angiogenin and rnases and in vivo and in vitro methods of using same 审中-公开
    血管生成素和血小板的小分子抑制剂和体内和体外使用方法

    公开(公告)号：US20070032418A1

    公开(公告)日：2007-02-08

    申请号：US10546855

    申请日：2004-02-25

    申请人： Robert Shapiro ,  Jeremy Jenkins ,  Richard Kao ,  Gary Latham

    发明人： Robert Shapiro ,  Jeremy Jenkins ,  Richard Kao ,  Gary Latham

    IPC分类号： A61K38/22 ,  A61K31/655 ,  A61K31/555 ,  A61K31/409 ,  C07D487/22

    CPC分类号： A61K31/015 ,  A61K31/15 ,  A61K31/167 ,  A61K38/39 ,  A61K45/06 ,  Y02A50/473 ,  A61K2300/00

    摘要： Lead compounds were obtained in a high throughput screen (HTS) of angiogenin (ANG; a potent inducer of angiogenesis) enzyme activity, an RNase. One lead was shown to delay appearance of tumors in an animal tumor system, and to reduce the number of animals having tumors. Several lead compound analogs were found to be even more potent inhibitors of ANG activity compared to the original leads, and two were also found to have greater affinity for ANG than for pancreatic RNase. Other embodiments disclose a method comprising obtaining a ribonuclease inhibitor and a composition; and admixing the ribonuclease inhibitor and the composition to form an admixture, wherein a ribonuclease that may be present in the admixture is inhibited.

    摘要翻译： 在血管生成素（ANG，血管发生的有效诱导剂）酶活性的高通量筛选（HTS），RNA酶中获得铅化合物。 显示出一个导联可以延缓肿瘤在动物肿瘤系统中的出现，并减少具有肿瘤的动物的数量。 与原始引物相比，发现几种铅化合物类似物是更有效的ANG活性抑制剂，并且还发现两种与ANG相比对于胰腺RNase具有更大的亲和力。 其他实施方案公开了包括获得核糖核酸酶抑制剂和组合物的方法; 并混合核糖核酸酶抑制剂和组合物以形成混合物，其中可以存在于混合物中的核糖核酸酶被抑制。

    Customized payment management
    5.
    发明授权
    Customized payment management 有权

    公开(公告)号：US10268996B1

    公开(公告)日：2019-04-23

    申请号：US14929195

    申请日：2015-10-30

    申请人： John D. Wannamaker ,  Erica S. Bjornsson ,  Calum G. Murray ,  John Robert Shapiro

    发明人： John D. Wannamaker ,  Erica S. Bjornsson ,  Calum G. Murray ,  John Robert Shapiro

    IPC分类号： G06Q20/10 ,  G06Q20/14

    摘要： A method for payment management includes identifying an invoice for a target financial transaction between a customer and a target vendor, and obtaining financial transaction records for completed financial transactions between the customer and vendors. The vendors include comparable vendors and the target vendor. The method further includes generating, using the financial transaction records, a payment prediction for the customer to pay the target vendor, analyzing a subset of the financial transaction records for the comparable vendors to generate a recommendation, and presenting, in a graphical user interface, the payment prediction and the recommendation.

    Computer system failure reporting mechanism
    6.
    发明授权
    Computer system failure reporting mechanism 失效
    计算机系统故障报告机制

    公开(公告)号：US06230286B1

    公开(公告)日：2001-05-08

    申请号：US08408127

    申请日：1995-03-21

    申请人： Robert Shapiro ,  Paul Andrew Dorwin

    发明人： Robert Shapiro ,  Paul Andrew Dorwin

    IPC分类号： G06F1114

    CPC分类号： G06F11/0784 ,  G06F11/0748 ,  G06F11/1417

    摘要： A mechanism is provided for a failed computer system to send a report of the failure to a remote site without dependency on a service processor or maintenance processor. The computer system is capable of reporting system failure to a remote site independent of whether the system may be successfully rebooted. The system includes a CPU, and, coupled to the CPU, a non-volatile control store, a main memory, a storage device storing a computer operating system, and a data modem. Firmware is resident in the non-volatile control store of the main computer system for reporting system failure to a remote site independent of whether the system may be successfully rebooted by reloading the operating system into main memory. The firmware is invoked upon occurrence of a non-recoverable error and provides for assembling failure-related information, establishing communication with the remote site, and transmitting the failure-related information to the remote site.

    摘要翻译： 为失败的计算机系统提供了一种机制来将失败的报告发送到远程站点，而不依赖于服务处理器或维护处理器。 计算机系统能够将系统故障报告给远程站点，而不管系统是否可以成功重新启动。 该系统包括CPU，并且耦合到CPU，非易失性控制存储器，主存储器，存储计算机操作系统的存储设备和数据调制解调器。 固件驻留在主计算机系统的非易失性控制存储器中，用于向远程站点报告系统故障，而不管系统是否可以通过将操作系统重新加载到主存储器中而成功重新启动。 在发生不可恢复的错误时调用固件，并提供组装故障相关信息，建立与远程站点的通信，并将故障相关信息发送到远程站点。

    Inhibitors of angiogenin
    7.
    发明授权
    Inhibitors of angiogenin 失效
    血管生成素抑制剂

    公开(公告)号：US5266687A

    公开(公告)日：1993-11-30

    申请号：US701478

    申请日：1991-05-16

    申请人： Robert Shapiro ,  Bert L. Vallee

    发明人： Robert Shapiro ,  Bert L. Vallee

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K14/515 ,  C12N15/00 ,  C07K7/00 ,  C12N9/22

    CPC分类号： C07K14/515 ,  C07K14/4703 ,  A61K38/00

    摘要： An inhibitor of angiogenin and method of use of the inhibitor, wherein the inhibitor inhibits the angiogenic activity of angiogenin. The inhibitor is dispensed at a suitable concentration within a physiologically compatable medium, suitable for administration to an animal in sufficient quantity to inhibit the biological activity of naturally occurring angiogenin within the animal.

    摘要翻译： 血管生成素的抑制剂和抑制剂的使用方法，其中所述抑制剂抑制血管生成素的血管生成活性。 将抑制剂以合适的浓度分配在生理上相容的培养基中，适于以足够的量施用于动物以抑制动物内天然存在的血管生成素的生物活性。

    Inhibitors of angiogenin
    8.
    发明授权
    Inhibitors of angiogenin 失效
    血管生成素抑制剂

    公开(公告)号：US5019556A

    公开(公告)日：1991-05-28

    申请号：US177942

    申请日：1988-04-05

    申请人： Robert Shapiro ,  Bert L. Vallee

    发明人： Robert Shapiro ,  Bert L. Vallee

    IPC分类号： A61K38/55 ,  A61K38/00 ,  A61P35/00 ,  C07H21/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/47 ,  C07K14/515 ,  C12N15/09

    CPC分类号： C07K14/515 ,  C07K14/4703 ,  A61K38/00 ,  Y10S530/851

    摘要： An inhibitor of angiogenin and method of use of the inhibitor, wherein the inhibitor inhibits the angiogenic activity of angiogenin. The inhibitor is dispensed at a suitable concentration within a physiologically compatable medium, suitable for administration to an animal in sufficient quantity to inhibit the biological activity of naturally occurring angiogenin within the animal.

    摘要翻译： 血管生成素的抑制剂和抑制剂的使用方法，其中所述抑制剂抑制血管生成素的血管生成活性。 将抑制剂以合适的浓度分配在生理上相容的培养基中，适于以足够的量施用于动物以抑制动物内天然存在的血管生成素的生物活性。

    Responsive Modification of Electronic Content
    9.
    发明申请
    Responsive Modification of Electronic Content 审中-公开
    电子内容的反应性修改

    公开(公告)号：US20140082045A1

    公开(公告)日：2014-03-20

    申请号：US13618457

    申请日：2012-09-14

    申请人： John Robert Shapiro ,  Joe Michael Andolina ,  Jakub Mateusz Burkot

    发明人： John Robert Shapiro ,  Joe Michael Andolina ,  Jakub Mateusz Burkot

    IPC分类号： G06F15/16

    CPC分类号： G06Q10/101 ,  G06Q50/01

    摘要： Systems and methods for responsive modification of electronic content are provided. In one embodiment, a moderator application executed by a processor accesses electronic content and provides the electronic content to a first client. The first client is restricted to accessing a first portion of a displayed area or frame sequence of the electronic content. The moderator application restricts the first client to performing only a first subset of modifications to the electronic content. Responsive to the first client performing one of the first subset of modifications, the moderator application provides the electronic content to a second client. The second client is restricted to accessing a second portion of the displayed area or the displayed frame sequence of the electronic content. The moderator application restricts the second client performing only a second subset of modifications to the electronic content.

    摘要翻译： 提供了电子内容响应修改的系统和方法。 在一个实施例中，由处理器执行的主持人应用访问电子内容并将电子内容提供给第一客户端。 第一客户端被限制为访问电子内容的显示区域或帧序列的第一部分。 主持人应用程序限制第一客户端仅执行对电子内容的修改的第一子集。 响应于第一客户端执行第一修改子集之一，主持人应用程序向第二客户端提供电子内容。 第二客户端被限制为访问所显示的区域的第二部分或电子内容的显示的帧序列。 主持人应用程序限制第二客户端仅执行电子内容的修改的第二子集。