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    ADHERENCE FACTORS OF NON PATHOGENIC MICROORGANISMS AND APPLICATIONS THEREOF FOR SCREENING MICROORGANISMS FOR SPECIFIC PROBIOTIC PROPERTIES; NOVEL PHARMACEUTICAL COMPOSITIONS AND FOOD ADDITIVES COMPRISING SUCH MICROORGANISMS AND ADHERENCE FACTORS
    1.
    发明授权
    ADHERENCE FACTORS OF NON PATHOGENIC MICROORGANISMS AND APPLICATIONS THEREOF FOR SCREENING MICROORGANISMS FOR SPECIFIC PROBIOTIC PROPERTIES; NOVEL PHARMACEUTICAL COMPOSITIONS AND FOOD ADDITIVES COMPRISING SUCH MICROORGANISMS AND ADHERENCE FACTORS 失效
    非致病微生物的辅助因子及其筛选特异性生物特性微生物的应用; 新型药物组合物和包含这些微生物和干扰因子的食品添加剂

    公开(公告)号：US06506389B2

    公开(公告)日：2003-01-14

    申请号：US09051755

    申请日：1998-09-30

    申请人： Robert Jan Leer ,  Pieter Hendrik Pouwels ,  Patricia Lynne Conway

    发明人： Robert Jan Leer ,  Pieter Hendrik Pouwels ,  Patricia Lynne Conway

    IPC分类号： A61K3907

    CPC分类号： C07K14/335 ,  A61K38/00 ,  Y02A50/47

    摘要： A protein obtainable from a non pathgenic microorgansim, said protein having mucosa binding promoting activity and a molecular weight of 20-40 kD is disclosed. Application of such a protein or a peptide derived therefrom in a method of screening non pathogenic microorganisms for a microorganism capable of specifically binding mucosa, said method comprising detection in a manner known per se of the presence of a particular protein on or in a microorganism or in a culture of microorganisms, said particular protein being the already defined protein. Kits suitable for such a screening method are also disclosed. Use of a component selected from the group of components comprising a protein or peptide as defined; an expression vector comprising nucleic acid encoding such protein or peptide; a recombinant microorganism or a part of said microorganism expressing such protein or peptide, said part expressing mucosa binding promoting activity; a non pathogenic microorganism capable of expressing such protein or peptide or a part of said microorganism, said part expressing mucosa binding promoting activity as pharmaceutically active component in a pharmaceutical composition for prophylaxis and/or treatment of disease or illness associated with a mucosa colonizing pathogenic microorganism. Use of such components as food additive and compositions comprising such components are described.

    摘要翻译： 可从非致病微生物获得的蛋白质，所述蛋白质具有粘膜结合促进活性和20-40kD的分子量。 将这种蛋白质或其衍生的肽应用于筛选非特异性结合粘膜的微生物的非病原微生物的方法中，所述方法包括以本身已知的方式检测特定蛋白质在微生物上或微生物中的存在，或 在微生物培养物中，所述特定蛋白质是已经定义的蛋白质。 还公开了适用于这种筛选方法的试剂盒。 使用选自包含定义的蛋白质或肽的组分组的组分; 包含编码这种蛋白质或肽的核酸的表达载体; 表达所述蛋白质或肽的重组微生物或所述微生物的一部分，所述部分表达粘膜结合促进活性; 能够表达这种蛋白质或肽或一部分所述微生物的非致病微生物，所述部分表达作为药物活性成分的粘膜结合促进活性，用于预防和/或治疗与粘膜定植病原微生物相关的疾病或疾病的药物组合物 。 描述了使用这些组分作为食品添加剂和包含这些组分的组合物。