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公开(公告)号：US20100144614A1
公开(公告)日：2010-06-10
申请号：US12173579
申请日：2008-07-15
IPC分类号： A61K38/16 , A01K67/00 , A61K31/7088
CPC分类号： G01N33/5035 , G01N33/5008 , G01N33/502 , G01N33/5023 , G01N33/5058 , G01N33/5088 , G01N33/6896 , G01N2500/00
摘要： The present invention provides methods for screening a pharmaceutical agent for its ability to modulate long term memory formation, performance of a hippocampal-dependent cognitive task or STAUFEN function. The present invention also provides methods for modulating long term memory formation or performance of a hippocampal-dependent cognitive task by modulating staufen-dependent protein expression. The present invention further provides methods for treating a defect in long term memory formation associated with a defect in STAUFEN and methods for treating a defect in performance of a hippocampal-dependent cognitive task associated with a defect in STAUFEN.
摘要翻译： 本发明提供了用于筛选药剂以调节长期记忆形成，执行海马依赖性认知任务或STAUFEN功能的能力的方法。 本发明还提供了通过调节staufen依赖性蛋白质表达来调节长期记忆形成或海马依赖性认知任务的表现的方法。 本发明还提供了用于治疗与STAUFEN中的缺陷相关的长期记忆形成缺陷的方法和用于治疗与STAUFEN中的缺陷相关的海马依赖性认知任务的缺陷的缺陷的方法。
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公开(公告)号：US20120171124A1
公开(公告)日：2012-07-05
申请号：US13364504
申请日：2012-02-02
CPC分类号： G01N33/5041 , C12Q1/66 , C12Q1/6811 , C12Q1/6888 , C12Q1/6897 , C12Q2600/136 , C12Q2600/158 , G01N33/5023 , G01N33/5058 , G01N33/5085 , G01N33/5088 , G01N33/6896
摘要： The present invention provides methods for identifying cognitive enhancers able to enhance CREB pathway function. Cognitive enhancers identified in accordance with the invention can be used in rehabilitating an animal with cognitive dysfunctions and for enhancing memory or normal cognitive performance (ability or function) in a normal animal.
摘要翻译： 本发明提供了用于鉴定能够增强CREB途径功能的认知增强剂的方法。 根据本发明鉴定的认知增强剂可用于恢复具有认知功能障碍的动物，并用于增强正常动物中的记忆或正常认知表现（能力或功能）。
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公开(公告)号：US20120094916A1
公开(公告)日：2012-04-19
申请号：US13305008
申请日：2011-11-28
CPC分类号： G01N33/5035 , G01N33/5008 , G01N33/502 , G01N33/5023 , G01N33/5058 , G01N33/5088 , G01N33/6896 , G01N2500/00
摘要： The present invention provides methods for screening a pharmaceutical agent for its ability to modulate long term memory formation, performance of a hippocampal-dependent cognitive task or STAUFEN function. The present invention also provides methods for modulating long term memory formation or performance of a hippocampal-dependent cognitive task by modulating staufen-dependent protein expression. The present invention further provides methods for treating a defect in long term memory formation associated with a defect in STAUFEN and methods for treating a defect in performance of a hippocampal-dependent cognitive task associated with a defect in STAUFEN.
摘要翻译： 本发明提供了用于筛选药剂以调节长期记忆形成，执行海马依赖性认知任务或STAUFEN功能的能力的方法。 本发明还提供了通过调节staufen依赖性蛋白质表达来调节长期记忆形成或海马依赖性认知任务的表现的方法。 本发明还提供了用于治疗与STAUFEN中的缺陷相关的长期记忆形成缺陷的方法和用于治疗与STAUFEN中的缺陷相关的海马依赖性认知任务的缺陷的缺陷的方法。
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公开(公告)号：US20140342943A1
公开(公告)日：2014-11-20
申请号：US14300896
申请日：2014-06-10
CPC分类号： G01N33/5041 , C12Q1/66 , C12Q1/6811 , C12Q1/6888 , C12Q1/6897 , C12Q2600/136 , C12Q2600/158 , G01N33/5023 , G01N33/5058 , G01N33/5085 , G01N33/5088 , G01N33/6896
摘要： The present invention provides methods for identifying cognitive enhancers able to enhance CREB pathway function. Cognitive enhancers identified in accordance with the invention can be used in rehabilitating an animal with cognitive dysfunction and for enhancing memory or normal cognitive performance (ability or function) in the animal.
摘要翻译： 本发明提供了用于鉴定能够增强CREB途径功能的认知增强剂的方法。 根据本发明鉴定的认知增强剂可用于恢复具有认知功能障碍的动物，并用于增强动物的记忆或正常认知表现（能力或功能）。
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公开(公告)号：US20110160248A1
公开(公告)日：2011-06-30
申请号：US12975862
申请日：2010-12-22
申请人： Xianbo Zhou , Roderick E.M. Scott , Rusiko Bourtchouladze , Alan P. Kaplan , Terence P. Keenan , Andrew McRiner
发明人： Xianbo Zhou , Roderick E.M. Scott , Rusiko Bourtchouladze , Alan P. Kaplan , Terence P. Keenan , Andrew McRiner
CPC分类号： C07D409/04 , A61K31/4152 , A61K31/4155 , A61K31/416 , A61K31/4178 , A61K31/454 , A61K31/496 , C07D231/12 , C07D231/14 , C07D401/04 , C07D401/10 , C07D401/14 , C07D409/14 , C07D417/14 , C07D451/06 , C07D453/02 , C07D453/04 , C07D471/08
摘要： The invention provides a compound of formula I: wherein R1-R6, X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of MAO-B enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.
摘要翻译： 本发明提供了式I化合物：其中R1-R6，X，Y和B具有本文所述的任何值，以及这些化合物的盐，包含这些化合物的组合物，以及包括施用这样的化合物的治疗方法 化合物。 这些化合物是MAO-B酶功能的抑制剂，可用于改善认知功能和治疗动物精神疾病。
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