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公开(公告)号：US20140342943A1
公开(公告)日：2014-11-20
申请号：US14300896
申请日：2014-06-10
CPC分类号： G01N33/5041 , C12Q1/66 , C12Q1/6811 , C12Q1/6888 , C12Q1/6897 , C12Q2600/136 , C12Q2600/158 , G01N33/5023 , G01N33/5058 , G01N33/5085 , G01N33/5088 , G01N33/6896
摘要： The present invention provides methods for identifying cognitive enhancers able to enhance CREB pathway function. Cognitive enhancers identified in accordance with the invention can be used in rehabilitating an animal with cognitive dysfunction and for enhancing memory or normal cognitive performance (ability or function) in the animal.
摘要翻译： 本发明提供了用于鉴定能够增强CREB途径功能的认知增强剂的方法。 根据本发明鉴定的认知增强剂可用于恢复具有认知功能障碍的动物，并用于增强动物的记忆或正常认知表现（能力或功能）。
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公开(公告)号：US20110160248A1
公开(公告)日：2011-06-30
申请号：US12975862
申请日：2010-12-22
申请人： Xianbo Zhou , Roderick E.M. Scott , Rusiko Bourtchouladze , Alan P. Kaplan , Terence P. Keenan , Andrew McRiner
发明人： Xianbo Zhou , Roderick E.M. Scott , Rusiko Bourtchouladze , Alan P. Kaplan , Terence P. Keenan , Andrew McRiner
CPC分类号： C07D409/04 , A61K31/4152 , A61K31/4155 , A61K31/416 , A61K31/4178 , A61K31/454 , A61K31/496 , C07D231/12 , C07D231/14 , C07D401/04 , C07D401/10 , C07D401/14 , C07D409/14 , C07D417/14 , C07D451/06 , C07D453/02 , C07D453/04 , C07D471/08
摘要： The invention provides a compound of formula I: wherein R1-R6, X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of MAO-B enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.
摘要翻译： 本发明提供了式I化合物：其中R1-R6，X，Y和B具有本文所述的任何值，以及这些化合物的盐，包含这些化合物的组合物，以及包括施用这样的化合物的治疗方法 化合物。 这些化合物是MAO-B酶功能的抑制剂，可用于改善认知功能和治疗动物精神疾病。
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公开(公告)号：US20050158243A1
公开(公告)日：2005-07-21
申请号：US11020026
申请日：2004-12-21
CPC分类号： G01N33/5035 , G01N33/5008 , G01N33/502 , G01N33/5023 , G01N33/5058 , G01N33/5088 , G01N33/6896 , G01N2500/00
摘要： The present invention provides methods for screening a pharmaceutical agent for its ability to modulate long term memory formation, performance of a hippocampal-dependent cognitive task or STAUFEN function. The present invention also provides methods for modulating long term memory formation or performance of a hippocampal-dependent cognitive task by modulating staufen-dependent protein expression. The present invention further provides methods for treating a defect in long term memory formation associated with a defect in STAUFEN and methods for treating a defect in performance of a hippocampal-dependent cognitive task associated with a defect in STAUFEN.
摘要翻译： 本发明提供了用于筛选药剂以调节长期记忆形成，执行海马依赖性认知任务或STAUFEN功能的能力的方法。 本发明还提供了通过调节staufen依赖性蛋白质表达来调节长期记忆形成或海马依赖性认知任务的表现的方法。 本发明还提供了用于治疗与STAUFEN中的缺陷相关的长期记忆形成缺陷的方法和用于治疗与STAUFEN中的缺陷相关的海马依赖性认知任务的缺陷的缺陷的方法。
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公开(公告)号：US09254282B2
公开(公告)日：2016-02-09
申请号：US12987592
申请日：2011-01-10
IPC分类号： A61K31/4164 , A61K31/4188 , A61K31/495 , A61K31/496 , A61K31/4015 , A61K31/435 , A61K31/445 , A61K31/45 , A61K31/451 , A61K31/00 , A61K31/519 , A61K38/17 , A61K45/06 , A61K48/00
CPC分类号： A61K31/45 , A01K15/02 , A61K31/00 , A61K31/4015 , A61K31/4164 , A61K31/4188 , A61K31/435 , A61K31/445 , A61K31/451 , A61K31/495 , A61K31/496 , A61K31/519 , A61K38/1709 , A61K45/06 , A61K48/00 , G09B19/00
摘要： The present invention provides methods of treating cognitive deficits associated with mental retardation. The methods comprise combining cognitive training protocols and a general administration of phosphodiesterase 4 inhibitors.
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公开(公告)号：US07919626B2
公开(公告)日：2011-04-05
申请号：US11679775
申请日：2007-02-27
申请人： Xianbo Zhou , Roderick E. M. Scott , Rusiko Bourtchouladze , Alan P. Kaplan , Terence P. Keenan , Andrew McRiner
发明人： Xianbo Zhou , Roderick E. M. Scott , Rusiko Bourtchouladze , Alan P. Kaplan , Terence P. Keenan , Andrew McRiner
IPC分类号： C07D211/00 , C07D295/00 , C07D211/30 , C07D211/32 , C07D211/20
CPC分类号： C07D409/04 , A61K31/4152 , A61K31/4155 , A61K31/416 , A61K31/4178 , A61K31/454 , A61K31/496 , C07D231/12 , C07D231/14 , C07D401/04 , C07D401/10 , C07D401/14 , C07D409/14 , C07D417/14 , C07D451/06 , C07D453/02 , C07D453/04 , C07D471/08
摘要： The invention provides a compound of formula I: wherein R1-R6, X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of MAO-B enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.
摘要翻译： 本发明提供了式I化合物：其中R1-R6，X，Y和B具有本文所述的任何值，以及这些化合物的盐，包含这些化合物的组合物，以及包括施用这样的化合物的治疗方法 化合物。 这些化合物是MAO-B酶功能的抑制剂，可用于改善认知功能和治疗动物精神疾病。
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公开(公告)号：US20100286213A9
公开(公告)日：2010-11-11
申请号：US11750900
申请日：2007-05-18
申请人： Thomas Hallam , Tim Tully , Rusiko Bourtchouladze
发明人： Thomas Hallam , Tim Tully , Rusiko Bourtchouladze
IPC分类号： A61K31/4418 , A61K31/40 , A61P25/00
CPC分类号： A61K31/40 , A61K31/00 , A61K31/435 , A61K31/4418 , A61K31/445 , A61K31/45 , A61K48/00
摘要： The present invention provides methods of improving cognitive and motor deficits associated with central nervous system (CNS) disorder or condition in an animal. The methods comprise a general administration of phosphodiesterase 4 inhibitors and optionally training the animal under conditions sufficient to produce an improvement in performance.
摘要翻译： 本发明提供了改善与动物中枢神经系统（CNS）病症或病症相关的认知和运动障碍的方法。 所述方法包括一般施用磷酸二酯酶4抑制剂，并且任选地在足以产生性能改善的条件下培养动物。
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公开(公告)号：US20080051437A1
公开(公告)日：2008-02-28
申请号：US11750900
申请日：2007-05-18
申请人： Thomas Hallam , Tim Tully , Rusiko Bourtchouladze
发明人： Thomas Hallam , Tim Tully , Rusiko Bourtchouladze
IPC分类号： A61K31/4418 , A61K31/40 , A61P25/00
CPC分类号： A61K31/40 , A61K31/00 , A61K31/435 , A61K31/4418 , A61K31/445 , A61K31/45 , A61K48/00
摘要： The present invention provides methods of improving cognitive and motor deficits associated with central nervous system (CNS) disorder or condition in an animal. The methods comprise a general administration of phosphodiesterase 4 inhibitors and optionally training the animal under conditions sufficient to produce an improvement in performance.
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公开(公告)号：US20070135509A1
公开(公告)日：2007-06-14
申请号：US11298116
申请日：2005-12-09
IPC分类号： A61K31/405
CPC分类号： A61K31/405
摘要： This invention provides a method of treating a subject suffering from a cognitive impairment or a cognitive disorder which comprises administering to the subject an amount of an indolone compound effective to treat the subject's cognitive impairment or disorder.
摘要翻译： 本发明提供了治疗患有认知障碍或认知障碍的受试者的方法，其包括向受试者施用一定量的有效治疗受试者的认知障碍或障碍的吲哚酮化合物。
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公开(公告)号：US08791137B2
公开(公告)日：2014-07-29
申请号：US12849418
申请日：2010-08-03
申请人： Xianbo Zhou , Roderick E. M. Scott , Rusiko Bourtchouladze , Alan P Kaplan , Terence P Keenan , Andrew McRiner
发明人： Xianbo Zhou , Roderick E. M. Scott , Rusiko Bourtchouladze , Alan P Kaplan , Terence P Keenan , Andrew McRiner
IPC分类号： A61K31/445 , C07D409/14
CPC分类号： C07D409/04 , A61K31/4152 , A61K31/4155 , A61K31/416 , A61K31/4178 , A61K31/454 , A61K31/496 , C07D231/12 , C07D231/14 , C07D401/04 , C07D401/10 , C07D401/14 , C07D409/14 , C07D417/14 , C07D451/06 , C07D453/02 , C07D453/04 , C07D471/08
摘要： The invention provides a compound of formula I: wherein R1-R6, X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of MAO-B enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.
摘要翻译： 本发明提供了式I化合物：其中R1-R6，X，Y和B具有本文所述的任何值，以及这些化合物的盐，包含这些化合物的组合物，以及包括施用这样的化合物的治疗方法 化合物。 这些化合物是MAO-B酶功能的抑制剂，可用于改善认知功能和治疗动物精神疾病。
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10.发明申请公开(公告)号：US20120196898A1
公开(公告)日：2012-08-02
申请号：US13439022
申请日：2012-04-04
IPC分类号： A61K31/451 , A61P25/00
CPC分类号： A61K31/40 , A61K31/00 , A61K31/435 , A61K31/4418 , A61K31/445 , A61K31/45 , A61K48/00
摘要： The present invention provides methods of improving cognitive and motor deficits associated with central nervous system (CNS) disorder or condition in an animal. The methods comprise a general administration of phosphodiesterase 4 inhibitors and optionally training the animal under conditions sufficient to produce an improvement in performance.
摘要翻译： 本发明提供了改善与动物中枢神经系统（CNS）病症或病症相关的认知和运动障碍的方法。 所述方法包括一般施用磷酸二酯酶4抑制剂，并且任选地在足以产生性能改善的条件下培养动物。
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