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1.发明申请METHODS OF PREPARATION OF RECOMBINANT FORMS OF HUMAN BETA-AMYLOID PROTEIN AND USES OF THESE PROTEINS 有权人β-淀粉样蛋白重组体的制备方法和这些蛋白质的使用公开(公告)号：US20090214515A1
公开(公告)日：2009-08-27
申请号：US11574844
申请日：2006-11-30
申请人： Thomas F. Holzman , John E. Harlan , Rohinton P. Edalji , Edward T. Olejniczak , Ana Pereda-Lopez , Boris Labkovsky , Liping Yu , Heinz Hillen , Stefan Barghorn , Ulrich M. Ebert
发明人： Thomas F. Holzman , John E. Harlan , Rohinton P. Edalji , Edward T. Olejniczak , Ana Pereda-Lopez , Boris Labkovsky , Liping Yu , Heinz Hillen , Stefan Barghorn , Ulrich M. Ebert
IPC分类号： A61K39/395 , C07K14/00 , C07H21/00 , C12N15/74 , C12N1/00 , C12P21/00 , C12N1/16 , C12N5/06 , C12N1/20 , C12N1/21 , C07K16/18 , C07K2/00 , G01N33/53 , A61K39/00 , A61P25/28
CPC分类号： C07K14/4711 , A61K38/00 , C07K16/18
摘要： The subject invention relates to the cloning, expression and isolation of recombinant forms of beta-amyloid protein containing a N-terminal methionine (or one or more amino acids) as well as to methods of using this recombinant protein in the production of therapeutic antibodies, in the identification of therapeutic small molecules, and in the performance of diagnostic assays.
摘要翻译： 本发明涉及含有N-末端甲硫氨酸（或一种或多种氨基酸）的重组形式的β-淀粉样蛋白的克隆，表达和分离以及在制备治疗性抗体中使用该重组蛋白的方法， 在鉴定治疗性小分子时，以及在诊断测定中的表现。
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2.发明授权Methods of preparation of recombinant forms of human beta-amyloid protein and uses of these proteins 有权人β-淀粉样蛋白重组形式的制备方法及其应用公开(公告)号：US08263558B2
公开(公告)日：2012-09-11
申请号：US11574844
申请日：2006-11-30
申请人： Thomas F. Holzman , John E. Harlan , Rohinton P. Edalji , Edward T. Olejniczak , Ana Pereda-Lopez , Boris Labkovsky , Liping Yu , Heinz Hillen , Stefan Barghorn , Ulrich M. Ebert
发明人： Thomas F. Holzman , John E. Harlan , Rohinton P. Edalji , Edward T. Olejniczak , Ana Pereda-Lopez , Boris Labkovsky , Liping Yu , Heinz Hillen , Stefan Barghorn , Ulrich M. Ebert
IPC分类号： A61K38/16 , A61K39/00 , C07K14/435 , C07H21/00 , C12P21/06 , C12N15/09 , C12N15/12 , C12N15/63
CPC分类号： C07K14/4711 , A61K38/00 , C07K16/18
摘要： The subject invention relates to the cloning, expression and isolation of recombinant forms of beta-amyloid protein containing a N-terminal methionine (or one or more amino acids) as well as to methods of using this recombinant protein in the production of therapeutic antibodies, in the identification of therapeutic small molecules, and in the performance of diagnostic assays.
摘要翻译： 本发明涉及含有N-末端甲硫氨酸（或一种或多种氨基酸）的重组形式的β-淀粉样蛋白的克隆，表达和分离以及在制备治疗性抗体中使用该重组蛋白的方法， 在鉴定治疗性小分子时，以及在诊断测定中的表现。
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