利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

4 条记录 (耗时 0.064 秒)

    Amyloid ß peptide analogues, oligomers thereof, processes for preparing and composi-tions comprising said analogues or oligomers, and their uses
    3.
    发明申请
    Amyloid ß peptide analogues, oligomers thereof, processes for preparing and composi-tions comprising said analogues or oligomers, and their uses 审中-公开
    淀粉样蛋白β肽类似物，其低聚物，包含所述类似物或寡聚物的制备和组合的方法及其用途

    公开(公告)号：US20110092445A1

    公开(公告)日：2011-04-21

    申请号：US12509325

    申请日：2009-07-24

    申请人： Stefan Barghorn ,  Heinz Hillen ,  Rohinton Edalji ,  Leo Barrett ,  Paul Richardson ,  Liping Yu ,  Edward Olejniczak ,  John E. Harlan ,  Thomas Holzman

    发明人： Stefan Barghorn ,  Heinz Hillen ,  Rohinton Edalji ,  Leo Barrett ,  Paul Richardson ,  Liping Yu ,  Edward Olejniczak ,  John E. Harlan ,  Thomas Holzman

    IPC分类号： A61K38/12 ,  C07K4/00 ,  C07K14/00 ,  G01N33/68

    CPC分类号： C07K14/4711 ,  A61K38/00 ,  C07K16/18 ,  C07K2319/00 ,  G01N2333/4709 ,  G01N2500/04 ,  G01N2800/2821

    摘要： The present invention relates to an amyloid β peptide analogues comprising an amino acid sequence or a peptidomimetic thereof, wherein the sequence (i) forms a loop, (ii) has at least 66% identity to the amino acid sequence of native Aβ peptide or a portion thereof, (iii) comprises at least 6 contiguous amino acid residues and (iv) has at least 2 non-contiguous amino acid residues which are covalently linked with each other, oligomers comprising a plurality of said amyloid β peptide analogues, processes for preparing the amyloid β peptide analogues or oligomers, compositions comprising the amyloid β peptide analogues or oligomers, and uses of the amyloid β peptide analogues or oligomers such as their use for treating or preventing an amyloidosis (e.g. by active immunization), for diagnosing an amyloidosis, and for providing agents that are capable of binding to the amyloid β peptide analogues or oligomers. The subject invention also describes agents that are capable of binding to the amyloid β peptide analogues or oligomers, e.g. antibodies, compositions comprising the agents, and uses of the agents such as their use for treating or preventing an amyloidosis (e.g. by passive immunization) and for diagnosing an amyloidosis.

    摘要翻译： 本发明涉及淀粉样蛋白 肽类似物，其包含氨基酸序列或其拟肽，其中所述序列（i）形成环，（ii）与天然A和Bgr的氨基酸序列具有至少66％的同一性; 肽或其一部分，（iii）包含至少6个连续氨基酸残基和（iv）具有彼此共价连接的至少2个不连续氨基酸残基，包含多个所述淀粉样蛋白和bgr的寡聚物; 肽类似物，制备淀粉样蛋白的方法 肽类似物或寡聚物，包含淀粉样蛋白的组合物; 肽类似物或寡聚物，以及淀粉样蛋白和bgr的用途; 肽类似物或寡聚体，例如其用于治疗或预防淀粉样变性（例如通过主动免疫）用于诊断淀粉样变性的用途，以及用于提供能够结合淀粉样蛋白的药剂; 肽类似物或寡聚物。 本发明还描述了能够结合淀粉样蛋白的药剂; 肽类似物或寡聚物，例如 抗体，包含该试剂的组合物，以及该药剂的用途，例如其用于治疗或预防淀粉样变性（例如通过被动免疫）和用于诊断淀粉样变性的用途。