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1.发明申请公开(公告)号：US20120290607A1
公开(公告)日：2012-11-15
申请号：US13353196
申请日：2012-01-18
Applicant: Rohit Bhargava , Jin Tae Kwak , Saurabh Sinha
Inventor： Rohit Bhargava , Jin Tae Kwak , Saurabh Sinha
IPC: G06F17/30
CPC classification number: G06F19/345 , G06F19/00 , G16H50/20 , G16H50/70
Abstract: This application provides to a method for identifying one or more prostate tissue samples in a database that are closest to a test prostate sample, which can be used to aid pathologists when examining prostate tissues to attain reliable and consistent diagnoses of prostate cancer. Also provided are databases and computer algorithms that can be used with such methods.
Abstract translation: 本申请提供了一种用于鉴定数据库中最接近测试前列腺样品的一个或多个前列腺组织样品的方法，其可用于在检查前列腺组织时帮助病理学家以获得前列腺癌的可靠和一致的诊断。 还提供了可以与这些方法一起使用的数据库和计算机算法。
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公开(公告)号：US20120226709A1
公开(公告)日：2012-09-06
申请号：US13344461
申请日：2012-01-05
Applicant: Rohit Bhargava , Jin Tae Kwak , Saurabh Sinha
Inventor： Rohit Bhargava , Jin Tae Kwak , Saurabh Sinha
IPC: G06F17/30
CPC classification number: G06K9/0014 , G06K9/00134 , G06K9/6228 , G06K9/6289 , G06T7/0012 , G06T7/60 , G06T2207/30081
Abstract: This application provides to a method for identifying one or more prostate tissue samples in a database that are closest to a test prostate sample, which can be used to aid pathologists when examining prostate tissues to attain reliable and consistent diagnoses of prostate cancer. Also provided are databases and computer algorithms that can be used with such methods.
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3.发明授权公开(公告)号：US09230063B2
公开(公告)日：2016-01-05
申请号：US13353196
申请日：2012-01-18
Applicant: Rohit Bhargava , Jin Tae Kwak , Saurabh Sinha
Inventor： Rohit Bhargava , Jin Tae Kwak , Saurabh Sinha
CPC classification number: G06F19/345 , G06F19/00 , G16H50/20 , G16H50/70
Abstract: This application provides to a method for identifying one or more prostate tissue samples in a database that are closest to a test prostate sample, which can be used to aid pathologists when examining prostate tissues to attain reliable and consistent diagnoses of prostate cancer. Also provided are databases and computer algorithms that can be used with such methods.
Abstract translation: 本申请提供了一种用于鉴定数据库中最接近测试前列腺样品的一个或多个前列腺组织样品的方法，其可用于在检查前列腺组织时帮助病理学家以获得前列腺癌的可靠和一致的诊断。 还提供了可以与这些方法一起使用的数据库和计算机算法。
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公开(公告)号：US20120092663A1
公开(公告)日：2012-04-19
申请号：US13273684
申请日：2011-10-14
Applicant: Linda S. Kull , Rohit Bhargava , Bridget Owen , Matthew Schulmerich , Dennis Thompson , John McKinney
Inventor： Linda S. Kull , Rohit Bhargava , Bridget Owen , Matthew Schulmerich , Dennis Thompson , John McKinney
CPC classification number: G01N21/65
Abstract: The disclosure provides instrumentation for the Raman spectroscopy analysis of seeds or grains, which can be used to determine the composition of the seed, such as its protein and oil content. In some examples the instrumentation includes an illumination device that emits light in the near infrared range, a sample holder to hold the seeds, and a collection device (e.g., Raman spectrograph) that captures the lights emitted by the seeds. Methods of determining the composition of seeds, such as soybeans, using Raman spectroscopy, are also provided.
Abstract translation: 本公开提供了用于种子或谷粒的拉曼光谱分析的仪器，其可用于确定种子的组成，例如其蛋白质和油含量。 在一些示例中，仪器包括发射近红外范围的光的照明装置，用于保持种子的样本保持器以及捕获由种子发射的光的收集装置（例如，拉曼光谱仪）。 还提供了使用拉曼光谱测定种子组成如黄豆的方法。
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公开(公告)号：US20120052063A1
公开(公告)日：2012-03-01
申请号：US13222623
申请日：2011-08-31
Applicant: Rohit Bhargava , F. Nell Pounder , Rohith K. Reddy
Inventor： Rohit Bhargava , F. Nell Pounder , Rohith K. Reddy
IPC: A61K39/395 , G06K9/00 , A61P35/00
CPC classification number: G06K9/6277
Abstract: The present disclosure relates to methods of analyzing breast tumor samples, for example as a means to determine whether the tumor is cancerous or benign. For example, it is shown herein that analysis of a Fourier transform infrared (FT-IR) spectroscopic image allows for automated detection of breast cancer or benign breast tumors with high accuracy.
Abstract translation: 本公开涉及分析乳腺肿瘤样品的方法，例如作为确定肿瘤是癌性还是良性的手段。 例如，这里示出了傅立叶变换红外（FT-IR）分光图像的分析，可以高精度自动检测乳腺癌或良性乳腺肿瘤。
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Patent Agency Ranking
公开(公告)号：US09779283B2
公开(公告)日：2017-10-03
申请号：US13344461
申请日：2012-01-05
Applicant: Rohit Bhargava , Jin Tae Kwak , Saurabh Sinha
Inventor： Rohit Bhargava , Jin Tae Kwak , Saurabh Sinha
CPC classification number: G06K9/0014 , G06K9/00134 , G06K9/6228 , G06K9/6289 , G06T7/0012 , G06T7/60 , G06T2207/30081
Abstract: This application provides to a method for identifying one or more prostate tissue samples in a database that are closest to a test prostate sample, which can be used to aid pathologists when examining prostate tissues to attain reliable and consistent diagnoses of prostate cancer. Also provided are databases and computer algorithms that can be used with such methods.
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公开(公告)号：US08593630B2
公开(公告)日：2013-11-26
申请号：US12900172
申请日：2010-10-07
Applicant: Rohit Bhargava , Brian T. Cunningham
Inventor： Rohit Bhargava , Brian T. Cunningham
IPC: G01J3/40
CPC classification number: G01J3/12 , G01J3/02 , G01J3/0202 , G01J3/0275 , G01J3/0286 , G01J3/0289 , G01N21/35
Abstract: Described herein are spectrometers comprising one or more wavelength-selective filters, such as guided mode resonance filters. Some of the spectrometers described herein are configured for obtaining absorbance spectra in a discrete fashion by measuring absorbances of a sample at multiple discrete wavelengths or wavelength bands. In another aspect, methods are also provided for obtaining spectra, images and chemical maps of samples in a discrete fashion.
Abstract translation: 这里描述的是包括一个或多个波长选择性滤波器的光谱仪，例如导模谐振滤波器。 这里描述的一些光谱仪被配置为通过测量在多个离散波长或波长带上的样品的吸光度以离散的方式获得吸收光谱。 在另一方面，还提供了用于以离散方式获得样品的光谱，图像和化学图谱的方法。
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8.发明申请TAILORED RAMAN SPECTROCOPIC PROBES FOR ULTRASENSITIVE AND HIGHLY MULTIPLEXED ASSAYS 有权用于超声波和高度多重测试的定制拉曼光谱探测器公开(公告)号：US20120212733A1
公开(公告)日：2012-08-23
申请号：US13277674
申请日：2011-10-20
Applicant: Anil K. Kodali , Xavier Llora , Rohit Bhargava
Inventor： Anil K. Kodali , Xavier Llora , Rohit Bhargava
CPC classification number: B01J13/22 , B82Y15/00 , B82Y40/00 , C09B67/0007 , C09B67/0097 , G01N21/658
Abstract: Embodiments of nanostructured, multilayered metal-dielectric particles suitable for use as Raman spectroscopic probes are disclosed, as well as methods of designing, making and using such multilayered nanoparticles, and kits including the multilayered nanoparticles. The multilayered nanoparticles include alternating metal and dielectric layers and an outer dielectric shell. One or more of the dielectric layers may include a plurality of reporter molecules. Embodiments of the multilayered nanoparticles are suitable for detecting target analytes in a sample. Some embodiments of the multilayered nanoparticles are suitable for use in multiplexed assays, including assays for multiple target analytes having differing concentrations.
Abstract translation: 公开了适合用作拉曼光谱探针的纳米结构多层金属 - 电介质颗粒的实施方案，以及设计，制备和使用这种多层纳米颗粒的方法，以及包括多层纳米颗粒的试剂盒。 多层纳米颗粒包括交替的金属和电介质层和外部电介质外壳。 介电层中的一个或多个可包括多个报道分子。 多层纳米颗粒的实施方案适用于检测样品中的目标分析物。 多层纳米颗粒的一些实施方案适用于多重测定，包括具有不同浓度的多种目标分析物的测定。
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9.发明申请公开(公告)号：US20150268226A1
公开(公告)日：2015-09-24
申请号：US13090384
申请日：2011-04-20
Applicant: Rohit Bhargava , Saurabh Sinha , Jin Tae Kwak
Inventor： Rohit Bhargava , Saurabh Sinha , Jin Tae Kwak
CPC classification number: G01N33/5091 , G01N2021/3595 , G01N2800/7028
Abstract: The present disclosure relates to methods of diagnosing prostate cancer using different imaging methods. For example, it is shown herein that combining a Fourier transform infrared (FT-IR) spectroscopic image with an optical image (such as a hematoxylin and eosin image) allows for automated detection of prostate cancer with high accuracy.
Abstract translation: 本公开涉及使用不同成像方法诊断前列腺癌的方法。 例如，这里示出了将傅里叶变换红外（FT-IR）光谱图像与光学图像（例如苏木精和曙红图像）组合允许以高精度自动检测前列腺癌。
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10.发明授权Tailored raman spectrocopic probes for ultrasensitive and highly multiplexed assays 有权定制的拉曼光谱探针用于超敏感和高度多重测定公开(公告)号：US08873038B2
公开(公告)日：2014-10-28
申请号：US13277674
申请日：2011-10-20
Applicant: Anil K. Kodali , Xavier Llora , Rohit Bhargava
Inventor： Anil K. Kodali , Xavier Llora , Rohit Bhargava
CPC classification number: B01J13/22 , B82Y15/00 , B82Y40/00 , C09B67/0007 , C09B67/0097 , G01N21/658
Abstract: Embodiments of nanostructured, multilayered metal-dielectric particles suitable for use as Raman spectroscopic probes are disclosed, as well as methods of designing, making and using such multilayered nanoparticles, and kits including the multilayered nanoparticles. The multilayered nanoparticles include alternating metal and dielectric layers and an outer dielectric shell. One or more of the dielectric layers may include a plurality of reporter molecules. Embodiments of the multilayered nanoparticles are suitable for detecting target analytes in a sample. Some embodiments of the multilayered nanoparticles are suitable for use in multiplexed assays, including assays for multiple target analytes having differing concentrations.
Abstract translation: 公开了适合用作拉曼光谱探针的纳米结构多层金属 - 电介质颗粒的实施方案，以及设计，制备和使用这种多层纳米颗粒的方法，以及包括多层纳米颗粒的试剂盒。 多层纳米颗粒包括交替的金属和电介质层和外部电介质外壳。 介电层中的一个或多个可包括多个报道分子。 多层纳米颗粒的实施方案适用于检测样品中的目标分析物。 多层纳米颗粒的一些实施方案适用于多重测定，包括具有不同浓度的多种目标分析物的测定。
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