公开(公告)号：US20090048194A1

公开(公告)日：2009-02-19

申请号：US11815688

申请日：2006-02-08

申请人： Jeroen Marcel Maria Roger Aerssens ,  Pieter Johau Peeters ,  Ann Louise Gabrielle Meulemans ,  Bernard Coulie ,  Kirk Hillsley ,  David Grundy ,  Ronald Stead

发明人： Jeroen Marcel Maria Roger Aerssens ,  Pieter Johau Peeters ,  Ann Louise Gabrielle Meulemans ,  Bernard Coulie ,  Kirk Hillsley ,  David Grundy ,  Ronald Stead

IPC分类号： A61K31/70 ,  C12Q1/68 ,  C40B30/04 ,  A61P1/00 ,  C40B40/08

CPC分类号： C12Q1/6809

摘要： A method of identifying a compound capable of reducing or preventing prolonged sensory neuron hyper-excitability comprising the steps of: (a) administering the compound to an experimental non-human animal having prolonged sensory neuron hyper-excitability; (b) generating an expression profile of the genes modulated in the Nodose Ganglia (NG) of the animal of step (a); (c) comparing the expression profile obtained in (b) with the expression profile of a corresponding panel of genes expressed in the NG of an experimental non-human animal having no prolonged sensory neuron hyper-excitability; wherein a positive correlation of the expression profiles is indicative that the compound is capable of reducing or preventing prolonged sensory neuron hyper-excitability in NG.

摘要翻译： 鉴定能够减少或预防延长的感觉神经元超兴奋性的化合物的方法，包括以下步骤：（a）将化合物施用于具有延长的感觉神经元超兴奋性的实验性非人动物; （b）产生在步骤（a）的动物的Nodose神经节（NG）中调节的基因的表达谱; （c）将（b）中获得的表达谱与在没有延长的感觉神经元超兴奋性的实验非人动物的NG中表达的相应基因组的表达谱进行比较; 其中所述表达谱的正相关表明所述化合物能够降低或预防NG中延长的感觉神经元超兴奋性。

公开(公告)号：US20060171857A1

公开(公告)日：2006-08-03

申请号：US11346876

申请日：2006-02-03

申请人： Ronald Stead ,  Xuan Bui

发明人： Ronald Stead ,  Xuan Bui

IPC分类号： B01L3/00

CPC分类号： G01N1/312 ,  B01L3/502715 ,  B01L9/52 ,  B01L2300/041 ,  B01L2300/0822 ,  B01L2300/0877 ,  B01L2400/0406 ,  B01L2400/0457 ,  B01L2400/0487 ,  B01L2400/0677 ,  G01N35/00029 ,  G01N2035/00138 ,  Y10T436/11 ,  Y10T436/112499

摘要： A sample, or slide, retaining tray includes a reagent reservoir, or recess, and a reaction chamber. A slide, or other sample container, can be positioned on the sample retaining tray as desired, with a tissue specimen face down, between a platen on the tray and the slide. A reagent from the reservoir is rendered flowable, such as by heating, and flows from the reservoir into the reaction chamber. Optionally, reagents or other fluids can be provided from above, by dripping onto a drip surface of the sample retaining tray, or below via an inlet port in the platen.

摘要翻译： 样品或滑动保持托盘包括试剂储存器，凹槽和反应室。 幻灯片或其他样品容器可以根据需要定位在样品保持托盘上，组织样本面朝下，托盘上的压板和载玻片之间。 来自储存器的试剂例如通过加热使其流动，并从储存器流入反应室。 任选地，可以从上方通过经由压板中的入口滴落到样品保持盘的滴水表面上或下方来提供试剂或其它流体。

公开(公告)号：US4998508A

公开(公告)日：1991-03-12

申请号：US352561

申请日：1989-05-16

申请人： Ronald Stead

发明人： Ronald Stead

IPC分类号： F22B37/00 ,  F22B1/02 ,  F22B1/18 ,  F22B9/10 ,  F22B9/12 ,  F22B37/40 ,  F24H8/00

CPC分类号： F22B9/12 ,  F24H8/00 ,  Y02B30/102

摘要： A boiler comprises a shell for fluid to be treated and divided into first and second heat exhange zones by at least one baffle, the zones being in communication with one another beneath a lower end of the baffle. Exhaust gases from a combustion source are supplied to a plurality of heat exchange tubes extending through each zone in heat exchange relationship with the fluid in the shell and being arranged in passes sequentially connected to one another whereby the exhaust gases pass sequentially through the first and second zones. The fluid to be heated is fed to an upper region of the second zone such that the temperature of gases passing through at least some of the tubes in the second zone falls to below the dew points of combustion products therein, the tubes in which condensation occurs being orientated such that condensates flow therefrom for disposal.

摘要翻译： 锅炉包括用于要处理的流体的壳体，并通过至少一个挡板分成第一和第二散热区域，所述区域在挡板的下端彼此连通。 来自燃烧源的废气被供给到与壳体中的流体以热交换关系延伸穿过每个区域的多个热交换管，并且被顺序地彼此连接，排气顺序地通过第一和第二 区域。 待加热的流体被供给到第二区域的上部区域，使得通过第二区域中的至少一些管道的气体的温度落在其内的燃烧产物的露点以下，发生冷凝的管道 定向使得冷凝物从其中流出以便处理。

公开(公告)号：US20050011354A1

公开(公告)日：2005-01-20

申请号：US10727382

申请日：2003-12-04

申请人： Ronald Stead

发明人： Ronald Stead

IPC分类号： B01D46/10 ,  B01D47/06 ,  B01D53/02 ,  B01D47/00

CPC分类号： B01D50/002 ,  B01D46/0038 ,  B01D46/10 ,  B01D47/06 ,  B01D53/02

摘要： An air filtration and aromatizer apparatus which includes a housing, a motor in the housing with a fan for drawing air through an inlet toward an outlet through a pollution-collecting chamber, and an elongated hollow tubular perforated member having an upper end connected to the motor output shaft and a lower end disposed in a bath of water. The hollow tubular member is formed in such a manner that as it is rotated by the motor, it draws water from the container under the influence of centrifugal force, and then forces the water through the perforations to form a mist or rain-like atmosphere in the path of motion of the air passing from the housing inlet toward the housing outlet.

摘要翻译： 一种空气过滤和芳香化装置，其包括壳体，壳体中的电动机，具有用于通过入口朝向出口通过污染物收集室抽吸空气的风扇以及具有连接到电动机的上端的细长的中空管状穿孔构件 输出轴和设置在水浴中的下端。 中空的管状构件以电动机旋转的方式形成，在离心力的影响下从容器中吸水，然后迫使水穿过穿孔，形成雾状或雨状的气氛 从壳体入口向壳体出口流动的空气的运动路径。

公开(公告)号：USD274019S

公开(公告)日：1984-05-29

申请号：US318029

申请日：1981-11-04

申请人： Ronald Stead ,  Eunice L. Stead

设计人： Ronald Stead ,  Eunice L. Stead