公开(公告)号：US12128414B2

公开(公告)日：2024-10-29

申请号：US17929369

申请日：2022-09-02

申请人： Mesa Biotech, Inc.

发明人： Mark Nowakowski ,  Michael Wang ,  Robert B Cary ,  Hong Cai ,  Conrad Lindberg ,  Martin Bouliane ,  Donald J Thomas

IPC分类号： B01L7/00 ,  B01L3/00 ,  C12Q1/04 ,  C12Q1/6816 ,  C12Q1/6844

CPC分类号： B01L7/52 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L3/502761 ,  B01L3/502769 ,  C12Q1/04 ,  C12Q1/6816 ,  C12Q1/6844 ,  B01L3/502715 ,  B01L2200/0621 ,  B01L2200/0689 ,  B01L2200/147 ,  B01L2200/16 ,  B01L2300/048 ,  B01L2300/0822 ,  B01L2300/0883 ,  B01L2300/123 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/0445 ,  B01L2400/0457 ,  B01L2400/0638 ,  B01L2400/0677 ,  B01L2400/0694 ,  C12Q2531/113 ,  C12Q2560/00 ,  C12Q1/6816 ,  C12Q2565/629

摘要： An automated method for performing an assay of the present disclosure can be performed in a microfluidic device that is a lateral flow device having numerous features to ensure correct operation of the device under gravity, such as vent pockets for enabling the flow of sample fluid from one chamber to the next when the vent pocket is unsealed. Each chamber can have a reagent recess proximal to an inlet end of the chamber. A reagent pellet formed in a reagent recess can be effectively mixed with a sample as the sample flows into the chamber. A flexible circuit with patterned metallic electrical components disposed on a heat stable material can be in direct contact with fluid in the chambers and has resistive heating elements aligned with, for example, a chamber for performing an amplification reaction. A lateral flow detection chamber can include a capillary pool proximal to a sample receiving end of a lateral flow strip, providing effective mixing and dispersion of a sample with detection particles, as well as enhancing, uniformity of particle migration on the detection strip. The microfluidic device can be configured to be hermetically sealed, thereby preventing contamination of a testing environment.

公开(公告)号：US12128402B2

公开(公告)日：2024-10-29

申请号：US17686105

申请日：2022-03-03

申请人： HandyLab, Inc.

发明人： Kalyan Handique

IPC分类号： B01L7/00 ,  B01L3/00 ,  F16K99/00

CPC分类号： B01L3/502715 ,  B01L3/5025 ,  B01L3/5027 ,  B01L3/502723 ,  B01L3/502738 ,  B01L7/52 ,  F16K99/0001 ,  B01L2200/027 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2200/14 ,  B01L2300/021 ,  B01L2300/0636 ,  B01L2300/0681 ,  B01L2300/0809 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2300/165 ,  B01L2300/1805 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1844 ,  B01L2300/1894 ,  B01L2400/0677

摘要： The technology described herein generally relates to microfluidic cartridges configured to amplify and detect polynucleotides extracted from multiple biological samples in parallel. The technology includes a microfluidic substrate, comprising: a plurality of sample lanes, wherein each of the plurality of sample lanes comprises a microfluidic network having, in fluid communication with one another: an inlet; a first valve and a second valve; a first channel leading from the inlet, via the first valve, to a reaction chamber; and a second channel leading from the reaction chamber, via the second valve, to a vent.

公开(公告)号：US12103000B2

公开(公告)日：2024-10-01

申请号：US17995842

申请日：2021-04-09

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Elliot En-Yu Hui ,  Hinesh Vipul Patel

IPC分类号： B01L3/00

CPC分类号： B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/0689 ,  B01L2300/0861 ,  B01L2400/0677

摘要： The present invention is directed to the fabrication and use of phase-change material (PCM) membranes in microvalves for microfluidic systems. The microvalve may be fabricated by using a tissue-sectioning instrument to slice a thin membrane of PCM off of a block of PCM. The membrane may then be sandwiched between a plurality of microfluidic flow sections to act as a microvalve. At room temperature, the membrane may exist in a solid state to act as a zero-leakage seal and microvalve. Applying heat to the membrane may bring the membrane to a melting point, causing it to reach a liquid state. The microvalve in the liquid state may experience a surface tension effect by a material of the microfluidic flow sections, causing it to displace from a flow path and allow a fluid to pass from one microfluidic flow section to another.

公开(公告)号：US20240261605A1

公开(公告)日：2024-08-08

申请号：US18635937

申请日：2024-04-15

申请人： Justrite Manufacturing Company, LLC

发明人： Glen A. Carter

IPC分类号： A62C2/24 ,  A62C2/06 ,  A62C2/12 ,  A62C3/06 ,  B01L1/00 ,  E05B65/10 ,  E05C1/14 ,  E05C9/04 ,  E05C9/18 ,  E05F1/00 ,  E05F1/08 ,  E05F5/12 ,  F16K17/38 ,  F24F7/10 ,  F24F13/10

CPC分类号： A62C2/242 ,  A62C2/12 ,  F16K17/383 ,  F16K17/386 ,  F24F7/10 ,  F24F13/10 ,  A62C3/06 ,  A62C3/14 ,  B01L1/50 ,  B01L2200/082 ,  B01L2400/0677 ,  E05B65/104 ,  E05C1/14 ,  E05C9/046 ,  E05C9/1825 ,  E05F1/006 ,  E05F1/08 ,  E05F5/12 ,  E05Y2201/41 ,  E05Y2201/686 ,  E05Y2600/324 ,  E05Y2800/342 ,  E05Y2800/416 ,  E05Y2900/21

摘要： A safety cabinet includes an enclosure and at least one door to selectively seal the enclosure. The safety cabinet can be used to store, for example, flammable liquids, flammable waste, corrosives, pesticides, or combustible waste. The safety cabinet incorporates a thermally-actuated damper that includes a body, a valve plate, and a pivot assembly. The valve plate is disposed within the passage of the body such that the valve plate is movable between an open position and a closed position. The pivot assembly includes a biasing system adapted to bias the valve plate to the closed position and a fusible link interconnected between the body and the biasing system to constrain the valve plate from moving from the open position to the closed position. The fusible link is configured to melt at a predetermined temperature to thereby allow the biasing system to move the valve plate to the closed position.

公开(公告)号：US11957942B2

公开(公告)日：2024-04-16

申请号：US16893057

申请日：2020-06-04

申请人： Justrite Manufacturing Company, L.L.C.

发明人： Glen A. Carter

IPC分类号： A62C2/24 ,  A62C2/06 ,  A62C2/12 ,  A62C3/06 ,  F16K17/38 ,  F24F7/10 ,  F24F13/10 ,  B01L1/00 ,  E05B65/10 ,  E05C1/14 ,  E05C9/04 ,  E05C9/18 ,  E05F1/00 ,  E05F1/08 ,  E05F5/12

CPC分类号： A62C2/242 ,  A62C2/12 ,  F16K17/383 ,  F16K17/386 ,  F24F7/10 ,  F24F13/10 ,  A62C3/06 ,  A62C3/14 ,  B01L1/50 ,  B01L2200/082 ,  B01L2400/0677 ,  E05B65/104 ,  E05C1/14 ,  E05C9/046 ,  E05C9/1825 ,  E05F1/006 ,  E05F1/08 ,  E05F5/12 ,  E05Y2201/41 ,  E05Y2201/686 ,  E05Y2600/324 ,  E05Y2800/342 ,  E05Y2800/416 ,  E05Y2900/21

摘要： A safety cabinet includes an enclosure and at least one door to selectively seal the enclosure. The safety cabinet can be used to store, for example, flammable liquids, flammable waste, corrosives, pesticides, or combustible waste. The safety cabinet incorporates a thermally-actuated damper that includes a body, a valve plate, and a pivot assembly. The valve plate is disposed within the passage of the body such that the valve plate is movable between an open position and a closed position. The pivot assembly includes a biasing system adapted to bias the valve plate to the closed position and a fusible link interconnected between the body and the biasing system to constrain the valve plate from moving from the open position to the closed position. The fusible link is configured to melt at a predetermined temperature to thereby allow the biasing system to move the valve plate to the closed position.

公开(公告)号：US20240090804A1

公开(公告)日：2024-03-21

申请号：US18221654

申请日：2023-07-13

申请人： Life Patch International

发明人： Brigitte Chau Phan ,  Andrew Atilla Pal ,  Ramoncito M. Valencia ,  Donald Bollella

IPC分类号： A61B5/15 ,  A61B5/00 ,  A61B5/11 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/151 ,  A61B5/157 ,  B01L3/00 ,  B82Y15/00 ,  B82Y30/00 ,  G01N33/52

CPC分类号： A61B5/150969 ,  A61B5/0002 ,  A61B5/0022 ,  A61B5/1112 ,  A61B5/145 ,  A61B5/14514 ,  A61B5/14521 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150251 ,  A61B5/150358 ,  A61B5/150389 ,  A61B5/150755 ,  A61B5/15087 ,  A61B5/150984 ,  A61B5/151 ,  A61B5/157 ,  A61B5/4839 ,  A61B5/681 ,  A61B5/6833 ,  A61B5/72 ,  A61B5/7475 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B82Y15/00 ,  B82Y30/00 ,  G01N33/528 ,  A61B5/1411 ,  A61B2505/07 ,  A61B2560/0214 ,  A61B2560/0412 ,  A61B2562/028 ,  A61B2562/0285 ,  A61B2562/0295 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2200/143 ,  B01L2300/023 ,  B01L2300/027 ,  B01L2300/0636 ,  B01L2300/0681 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2400/049 ,  B01L2400/0655 ,  B01L2400/0677

摘要： Personal diagnostic devices including diagnostic patches (bio-patches) and interactive medical bracelets (bio-bracelets) are provided with a skin/patch interface, at least one analysis layer, a signal processing layer, and a user output interface. Embodiments of the interactive diagnostic devices may include micro-fluidic circuits with reaction chambers, analysis chambers, mixing cambers, and various pre-disposed chemistries or reagents for performing a wide verity of tests by trans-dermal transport of blood or perspiration. Sample collection chambers for the fluidic circuit may include minimally invasive tubules that penetrate the skin surface to acquire blood samples from capillaries near the epidermis. Alternate implementations of the personal diagnostic device may be equipped with logic processing, input/output devices, acoustic microphones, cryogenic circuits, embedded processors, electrical control circuitry, and battery current sources or photovoltaic sources of electrical power.

公开(公告)号：US11865534B2

公开(公告)日：2024-01-09

申请号：US13120533

申请日：2009-09-24

申请人： Bruce Walsh ,  Boris Blanter ,  Matthew Barra ,  Brian Connolly ,  Greg Yantz ,  Paul Gervasio ,  Don Straus

发明人： Bruce Walsh ,  Boris Blanter ,  Matthew Barra ,  Brian Connolly ,  Greg Yantz ,  Paul Gervasio ,  Don Straus

IPC分类号： B01L3/00 ,  G01N35/00 ,  G01N35/02 ,  G01N33/543 ,  A61B5/157 ,  G01N21/03 ,  G01N21/25 ,  G01N21/64 ,  A61B5/15 ,  A61B5/151 ,  B01L7/00 ,  B01L9/00 ,  A61B5/117 ,  G01N35/04

CPC分类号： B01L3/502715 ,  A61B5/157 ,  A61B5/150022 ,  A61B5/15113 ,  A61B5/15186 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150274 ,  A61B5/150305 ,  A61B5/150343 ,  A61B5/150351 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150786 ,  B01L3/5027 ,  B01L3/5029 ,  B01L3/5082 ,  B01L3/502738 ,  B01L3/502761 ,  G01N21/03 ,  G01N21/253 ,  G01N21/6452 ,  G01N21/6458 ,  G01N33/54373 ,  G01N35/0098 ,  G01N35/02 ,  G01N35/025 ,  A61B5/117 ,  A61B5/151 ,  B01L7/00 ,  B01L9/52 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2300/022 ,  B01L2300/042 ,  B01L2300/043 ,  B01L2300/046 ,  B01L2300/048 ,  B01L2300/0654 ,  B01L2300/0681 ,  B01L2300/0864 ,  B01L2400/043 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0415 ,  B01L2400/0457 ,  B01L2400/0472 ,  B01L2400/0481 ,  B01L2400/0677 ,  B01L2400/0683 ,  G01N21/6428 ,  G01N2021/0325 ,  G01N2021/0346 ,  G01N2035/0401 ,  G01N2035/0429

摘要： The invention provides analyzers that improve tests for detecting specific cellular, viral, and molecular targets in clinical, industrial, or environmental samples. The invention permits efficient and specific selection and sensitive imaging detection of individual microscopic targets at low magnification. Automated embodiments allow efficient walk-away, on-demand, random-access high-throughput testing. The analyzers perform tests without requiring wash steps thus streamlining engineering and lowering costs. Thus, the invention provides analyzers that can deliver rapid, accurate, and quantitative, easy-to-use, and cost-effective tests for analytes.

公开(公告)号：US11845081B2

公开(公告)日：2023-12-19

申请号：US17131558

申请日：2020-12-22

申请人： HANDYLAB, INC.

发明人： Jeff Williams ,  Kerry Wilson ,  Kalyan Handique

IPC分类号： B01L3/00 ,  B01L7/00 ,  B01L9/00 ,  F16K99/00 ,  B01L3/02 ,  B01L9/06 ,  G01N35/02 ,  G01N35/00 ,  G01N35/04

CPC分类号： B01L3/502761 ,  B01L3/0275 ,  B01L3/5027 ,  B01L3/52 ,  B01L7/52 ,  B01L9/06 ,  B01L9/527 ,  F16K99/0001 ,  F16K99/003 ,  F16K99/0032 ,  F16K99/0044 ,  F16K99/0061 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2200/147 ,  B01L2200/148 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/045 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/0681 ,  B01L2300/087 ,  B01L2300/0816 ,  B01L2300/0832 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/18 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1861 ,  B01L2400/0442 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0611 ,  B01L2400/0677 ,  B01L2400/0683 ,  F16K2099/0084 ,  G01N35/026 ,  G01N2035/00881 ,  G01N2035/0425 ,  G01N2035/0436

摘要： The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides.

公开(公告)号：US11737694B2

公开(公告)日：2023-08-29

申请号：US15994831

申请日：2018-05-31

申请人： Life Patch International

发明人： Brigitte Chau Phan ,  Andrew Atilla Pal ,  Ramoncito M. Valencia ,  Donald Bollella

IPC分类号： A61B5/15 ,  A61B5/145 ,  A61B5/00 ,  A61B5/11 ,  A61B5/1486 ,  B01L3/00 ,  B82Y15/00 ,  G01N33/52 ,  A61B5/151 ,  B82Y30/00 ,  A61B5/157 ,  A61B5/1455

CPC分类号： A61B5/150969 ,  A61B5/0002 ,  A61B5/0022 ,  A61B5/1112 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/14514 ,  A61B5/14521 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/151 ,  A61B5/157 ,  A61B5/150022 ,  A61B5/15087 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150251 ,  A61B5/150358 ,  A61B5/150389 ,  A61B5/150755 ,  A61B5/150984 ,  A61B5/4839 ,  A61B5/681 ,  A61B5/6833 ,  A61B5/72 ,  A61B5/7475 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B82Y15/00 ,  B82Y30/00 ,  G01N33/528 ,  A61B5/1411 ,  A61B2505/07 ,  A61B2560/0214 ,  A61B2560/0412 ,  A61B2562/028 ,  A61B2562/0285 ,  A61B2562/0295 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2200/143 ,  B01L2300/023 ,  B01L2300/027 ,  B01L2300/069 ,  B01L2300/0636 ,  B01L2300/0681 ,  B01L2300/087 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/049 ,  B01L2400/0655 ,  B01L2400/0677

摘要： Personal diagnostic devices including diagnostic patches (bio-patches) and interactive medical bracelets (bio-bracelets) are provided with a skin/patch interface, at least one analysis layer, a signal processing layer, and a user output interface. Embodiments of the interactive diagnostic devices may include micro-fluidic circuits with reaction chambers, analysis chambers, mixing cambers, and various pre-disposed chemistries or reagents for performing a wide verity of tests by transdermal transport of blood or perspiration. Sample collection chambers for the fluidic circuit may include minimally invasive tubules that penetrate the skin surface to acquire blood samples from capillaries near the epidermis. Alternate implementations of the personal diagnostic device may be equipped with logic processing, input/output devices, acoustic microphones, cryogenic circuits, embedded processors, electrical control circuitry, and battery current sources or photovoltaic sources of electrical power.

公开(公告)号：US20230256451A1

公开(公告)日：2023-08-17

申请号：US18172189

申请日：2023-02-21

申请人： ANDE Corporation

发明人： Richard F. Selden ,  Eugene Tan

IPC分类号： B01L7/00 ,  B01D69/02 ,  B01L3/00 ,  G01N27/447 ,  G01N27/26 ,  C12Q1/6806 ,  B29B11/08 ,  B29C45/00 ,  C12Q1/686 ,  C12Q1/6874

CPC分类号： B01L7/52 ,  B01D69/02 ,  B01L3/502707 ,  B01L3/502715 ,  G01N27/44704 ,  G01N27/44791 ,  B01L3/50273 ,  B01L3/502 ,  G01N27/26 ,  C12Q1/6806 ,  B01L3/502753 ,  B29B11/08 ,  B29C45/0025 ,  G01N27/44721 ,  B01L3/502723 ,  B01L3/502738 ,  C12Q1/686 ,  C12Q1/6874 ,  G01N27/44743 ,  Y10T29/4998 ,  B01L2300/087 ,  B01L2300/0874 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2200/142 ,  B01L2200/10 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/123 ,  B01L2300/1822 ,  B01L2400/0421 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0655 ,  B01L2400/0677 ,  B01L2400/0688 ,  B29C2045/0027 ,  B29K2101/12

摘要： A biochip for the integration of all steps in a complex process from the insertion of a sample to the generation of a result, performed without operator intervention includes microfluidic and macrofluidic features that are acted on by instrument subsystems in a series of scripted processing steps. Methods for fabricating these complex biochips of high feature density by injection molding are also provided.