Method of increasing bone density or treating osteoporosis
    3.
    发明授权
    Method of increasing bone density or treating osteoporosis 有权
    增加骨密度或治疗骨质疏松症的方法

    公开(公告)号:US07160916B2

    公开(公告)日:2007-01-09

    申请号:US10932323

    申请日:2004-09-01

    CPC classification number: A61K31/4162 A61K31/416

    Abstract: This invention features a method for enhancing bone growth or inhibiting bone resportion. The method includes administering to a subject in need thereof a compound of the following formula: A is H, R, or each of Ar1, Ar2, and Ar3, independently, is phenyl, thienyl, furyl, or pyrrolyl; each of R1, R2, R3, R4, R5, and R6, independently, is H, halogen, R, C(O)OH, C(O)OR, C(O)SH, C(O)SR, C(O)NH2, C(O)NHR, C(O)NRR′, ROH, ROR′, RSH, RSR′, NHR, NRR′, RNHR′, or RNR′R″; or R1 and R2 together, R3 and R4 together, or R5 and R6 together are ORO; wherein each of R, R′, and R″, independently is C1˜C6 alkyl; and n is 1, 2, or 3.

    Abstract translation: 本发明的特征在于增强骨生长或抑制骨重量的方法。 所述方法包括向有需要的受试者施用下式的化合物:A为H,R或Ar 1,Ar 2和Ar 3,独立地是苯基,噻吩基,呋喃基或吡咯基; R 1,R 2,R 3,R 4,R 5,和/或R 3中的每一个 (O)OH,C(O)OR,C(O)SH,C(O)SR,C(O) NHR,NRR',RNHR'或RNR'R“,其中R 1,R 2,R 2, 或R 1和R 2共同在一起,R 3和R 4一起,或R 5, / SUB>和R 6一起是ORO; 其中R,R'和R“各自独立地是C 1 -C 6烷基; 且n为1,2或3。

    Enhancement of bone growth and inhibition of bone resorption
    5.
    发明申请
    Enhancement of bone growth and inhibition of bone resorption 有权
    增强骨生长和抑制骨吸收

    公开(公告)号:US20050131048A1

    公开(公告)日:2005-06-16

    申请号:US10932323

    申请日:2004-09-01

    CPC classification number: A61K31/4162 A61K31/416

    Abstract: This invention features a method for enhancing bone growth or inhibiting bone resportion. The method includes administering to a subject in need thereof a compound of the following formula: A is H, R, or each of Ar1, Ar2, and Ar3, independently, is phenyl, thienyl, furyl, or pyrrolyl; each of R1, R2, R3, R4, R5, and R6, independently, is H, halogen, R, C(O)OH, C(O)OR, C(O)SH, C(O)SR, C(O)NH2, C(O)NHR, C(O)NRR′, ROH, ROR′, RSH, RSR′, NHR, NRR′, RNHR′, or RNR′R″; or R1 and R2 together, R3 and R4 together, or R5 and R6 together are ORO; wherein each of R, R′, and R″, independently is C1˜C6 alkyl; and n is 1, 2, or 3.

    Abstract translation: 本发明的特征在于增强骨生长或抑制骨重量的方法。 所述方法包括向有需要的受试者施用下式的化合物:A为H,R或Ar 1,Ar 2和Ar 3,独立地是苯基,噻吩基,呋喃基或吡咯基; R 1,R 2,R 3,R 4,R 5,和/或R 3中的每一个 (O)OH,C(O)OR,C(O)SH,C(O)SR,C(O) NHR,NRR',RNHR'或RNR'R“,其中R 1,R 2,R 2, 或R 1和R 2共同在一起,R 3和R 4一起,或R 5, / SUB>和R 6一起是ORO; 其中R,R'和R“各自独立地是C 1 -C 6烷基; 且n为1,2或3。

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