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1.发明授权Fluorescent isothiocyanate (fitc) sinistrin, its production and use 失效荧光异硫氰酸酯（fitc）sinistrin，其生产和使用公开(公告)号：US06995019B2
公开(公告)日：2006-02-07
申请号：US10276025
申请日：2001-05-08
申请人： Heinz-Michael Hein , Uwe Kraemer , Rudolf Reiter , Norbert Gretz , Carsten Deus
发明人： Heinz-Michael Hein , Uwe Kraemer , Rudolf Reiter , Norbert Gretz , Carsten Deus
IPC分类号： G01N21/64
CPC分类号： A61K49/0054 , A61K49/0043 , C08B37/0051 , Y10T436/143333
摘要： The invention concerns fluorescein isothiocyanate-sinistrin (FITC-sinistrin), a method for its production, its use as a marker substance in a diagnostic agent and a corresponding diagnostic agent.
摘要翻译： 本发明涉及异硫氰酸荧光素 - 西硝杆菌（FITC-sinistrin）的荧光素，其生产方法，其作为诊断剂中的标记物质和相应的诊断剂。
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2.发明授权Method and device for determining a light transport parameter in a biological matrix 有权用于确定生物矩阵中的光传输参数的方法和装置公开(公告)号：US07315752B2
公开(公告)日：2008-01-01
申请号：US10499109
申请日：2002-12-07
申请人： Uwe Kraemer , Heinz-Michael Hein , Marcus Hermann
发明人： Uwe Kraemer , Heinz-Michael Hein , Marcus Hermann
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0059 , A61B5/14532 , A61B2562/0233 , A61B2562/0242 , A61B2562/043 , G01N21/49
摘要： A method for the selective determination of the scattering index μs of a scattering biological matrix, in particular for the purpose of non-invasive determination of the concentration of glucose in the skin, by means of detection measurements, in each of which light in the form of primary light (9) is irradiated into the biological matrix (5) and an intensity measurement value of secondary light (12) exiting at a detection site (33-40) that is located at different measuring distances (ρ) from the respective light irradiation site (10) during the detection measurements is measured. In order to improve the quality and selectivity of the determination of μs, the primary light is irradiated obliquely at an angle between 5° and 85° using a contacting light-guiding element. In at least two detection measurements, the measuring distance (ρ) between the respective light irradiation site (10) and the respective detection site (33-40) corresponds to no more than five times the mean free path length of the light propagating in the biological matrix.
摘要翻译： 用于通过检测测量法选择性地确定散射生物基质的散射指数的方法，特别是用于非侵入性地测定皮肤中葡萄糖浓度的目的， 其中以原色光（9）的形式的光照射到生物基质（5）中，并且在位于不同测量点处的检测位置（33-40）处出射的次级光（12）的强度测量值 在检测测量期间测量来自相应的光照射部位（10）的距离（rho）。 为了提高测定的质量和选择性，使用接触光引导元件以5°和85°之间的角度倾斜地照射一次光。 在至少两次检测测量中，相应的光照射部位（10）和各个检测部位（33-40）之间的测量距离（rho）对应于不超过在 生物基质。
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3.发明申请Method and device for determining a light transport parameter in a biological matrix 有权用于确定生物矩阵中的光传输参数的方法和装置公开(公告)号：US20050002031A1
公开(公告)日：2005-01-06
申请号：US10499109
申请日：2002-12-07
申请人： Uwe Kraemer , Heinz-Michael Hein , Marcus Hermann
发明人： Uwe Kraemer , Heinz-Michael Hein , Marcus Hermann
CPC分类号： A61B5/1455 , A61B5/0059 , A61B5/14532 , A61B2562/0233 , A61B2562/0242 , A61B2562/043 , G01N21/49
摘要： A method for the selective determination of the scattering index μs of a scattering biological matrix, in particular for the purpose of non-invasive determination of the concentration of glucose in the skin, by means of detection measurements, in each of which light in the form of primary light (9) is irradiated into the biological matrix (5) and an intensity measurement value of secondary light (12) exiting at a detection site (33-40) that is located at different measuring distances (ρ) from the respective light irradiation site (10) during the detection measurements is measured. In order to improve the quality and selectivity of the determination of μs, the primary light is irradiated obliquely at an angle between 5° and 85° using a contacting light-guiding element. In at least two detection measurements, the measuring distance (ρ) between the respective light irradiation site (10) and the respective detection site (33-40) corresponds to no more than five times the mean free path length of the light propagating in the biological matrix.
摘要翻译： 一种用于选择性地确定散射生物基质的散射指数的方法，特别是通过检测测量来非侵入性地测定皮肤中葡萄糖浓度的目的，其中每种形式的光都是 的初级光（9）照射到生物基质（5）中，并且从位于与各个光的不同测量距离（rho）处的检测位置（33-40）处出射的次级光（12）的强度测量值 在检测测量期间测量照射部位（10）。 为了提高测定的质量和选择性，使用接触光引导元件以5°和85°之间的角度倾斜地照射一次光。 在至少两次检测测量中，相应的光照射部位（10）和各个检测部位（33-40）之间的测量距离（rho）对应于不超过在 生物基质。
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公开(公告)号：US06689616B1
公开(公告)日：2004-02-10
申请号：US09581650
申请日：2001-01-12
IPC分类号： G01N3300
CPC分类号： A61K49/006 , C08B37/0054 , G01N33/52
摘要： New dye-polysaccharide and dye-cyclosaccharide conjugates and their use as a diagnostic agent especially for determining the glomerular filtration rate in humans.
摘要翻译： 新型染料 - 多糖和染料 - 环状共轭物及其作为诊断剂的用途，特别用于测定人体肾小球滤过率。
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5.发明授权Method for the determination of a light transport parameter in a biological matrix 失效用于确定生物基质中光传输参数的方法公开(公告)号：US07565249B2
公开(公告)日：2009-07-21
申请号：US10471113
申请日：2002-02-23
申请人： Uwe Kraemer , Heinz-Michael Hein , Dietmar Volz
发明人： Uwe Kraemer , Heinz-Michael Hein , Dietmar Volz
CPC分类号： A61B5/1455 , A61B5/14532 , A61B2562/0242 , Y10T436/144444
摘要： A method is proposed for the selective determination of a light transport parameter which is characteristic for the light scattering in a biological matrix (5), in particular for the purpose of the non-invasive determination of the glucose concentration in the biological matrix. The method comprises providing a plurality of detection measurements, in which light is irradiated as primary light into the biological matrix and measuring an intensity value of secondary light emerging at a plurality detection sites, located in different measuring distances from the irradiation site. In an evaluation step, the light transport parameter is derived, by means of an evaluation algorithm, from the measured intensity values. For the selective determination of the scattering coefficient, the evaluation algorithm includes a step in which a time derivative value ΔtI(r) describing the change of the measurement intensity value versus time is calculated from intensity measurement values obtained at a minimum of two different points of time.
摘要翻译： 提出了一种用于选择性确定生物基质（5）中的光散射特征的光传输参数的方法，特别是为了非侵入性地确定生物基质中的葡萄糖浓度。 该方法包括提供多个检测测量，其中将光作为初级光照射到生物矩阵中并测量出位于与照射部位不同的测量距离的多个检测位置的二次光的强度值。 在评估步骤中，通过评估算法从测量的强度值导出光传输参数。 为了选择性地确定散射系数，评估算法包括一个步骤，其中描述测量强度值与时间的变化的时间导数值DeltatI（r）是从在两个不同点的最小两点获得的强度测量值计算的 时间。
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6.发明授权公开(公告)号：US07369952B2
公开(公告)日：2008-05-06
申请号：US10552248
申请日：2004-04-06
摘要： The invention relates to analysis methods for diagnosing diseases on human and animal samples. Said invention also relates to an evaluation method for diagnosing the individual stages of a disease in such a way that it is possible to display the progression thereof. Said invention also makes it possible to identify diseases in an early manner and to carry out therapeutic controls. The inventive method consists in carrying out actually known multivariable evaluation methods for classifying samples. Nevertheless, the invention is characterised in that no sample is allocated to a certain class, but it is classified in a data record based on the interpolation between different classes.
摘要翻译： 本发明涉及用于诊断人和动物样品疾病的分析方法。 本发明还涉及用于诊断疾病的各个阶段的评估方法，使得可以显示其进展。 所述发明还能够以早期的方式鉴定疾病并进行治疗控制。 本发明的方法在于实现用于分类样品的实际已知的多变量评价方法。 然而，本发明的特征在于，没有将样本分配给某一类，而是基于不同类之间的插值将其分类到数据记录中。
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公开(公告)号：US20060195296A1
公开(公告)日：2006-08-31
申请号：US10552248
申请日：2004-04-06
摘要： The invention relates to analysis methods for diagnosing diseases on human and animal samples. Said invention also relates to an evaluation method for diagnosing the individual stages of a disease in such a way that it is possible to display the progression thereof. Said invention also makes it possible to identify diseases in an early manner and to carry out therapeutic controls. The inventive method consists in carrying out actually known multivariable evaluation methods for classifying samples. Nevertheless, the invention is characterised in that no sample is allocated to a certain class, but it is classified in a data record based on the interpolation between different classes.
摘要翻译： 本发明涉及用于诊断人和动物样品疾病的分析方法。 本发明还涉及用于诊断疾病的各个阶段的评估方法，使得可以显示其进展。 所述发明还能够以早期的方式鉴定疾病并进行治疗控制。 本发明的方法在于实现用于分类样品的实际已知的多变量评价方法。 然而，本发明的特征在于，没有将样本分配给某一类，而是基于不同类之间的插值将其分类到数据记录中。
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公开(公告)号：US20110028862A1
公开(公告)日：2011-02-03
申请号：US12901290
申请日：2010-10-08
申请人： Heinz-Michael Hein , Reto Abt , Stephan Korner , Irio Giuseppe Calasso , Emad Sarofim , Patrick Griss , Rainer Jaeggi
发明人： Heinz-Michael Hein , Reto Abt , Stephan Korner , Irio Giuseppe Calasso , Emad Sarofim , Patrick Griss , Rainer Jaeggi
IPC分类号： A61B5/151
CPC分类号： A61B5/150503 , A61B5/0531 , A61B5/150022 , A61B5/150068 , A61B5/150167 , A61B5/150175 , A61B5/150358 , A61B5/150435 , A61B5/15107 , A61B5/15117 , A61B5/15123 , A61B5/15186
摘要： The present invention provides a method and a device for piercing a body part and determining whether a sufficient volume of blood has been withdrawn. A lancing element is rapidly inserted into a body part in a forward phase and retracted quickly to a lesser puncturing depth. Subsequently, the lancing element is retracted slower than during the first retraction movement and the distance retracted during the second retraction is shorter than the first retraction movement. During the second retraction movement, body fluid is collected in a collection phase by a capillary structure of the lancing element. Contact between the lancing element and the body fluid is detected after the forward phase at the beginning and the end of a waiting period.
摘要翻译： 本发明提供一种用于刺穿身体部位并确定是否已经抽出了足够体积的血液的方法和装置。 穿刺元件迅速地插入到前部的身体部位并且迅速地缩回到较小的穿刺深度。 随后，穿刺元件缩回比在第一缩回运动期间慢，并且在第二缩回期间缩回的距离比第一缩回运动短。 在第二回缩运动期间，体液通过穿刺元件的毛细结构收集在收集阶段。 在等待期开始和结束后的正向相位之后检测穿刺元件与体液之间的接触。
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公开(公告)号：US07586612B2
公开(公告)日：2009-09-08
申请号：US11463110
申请日：2006-08-08
IPC分类号： G01N21/00
CPC分类号： G01N21/0303 , B01L3/502715 , B01L2300/0654 , B01L2300/0806 , B01L2300/168 , G01N35/00069
摘要： On an analytical device for photometric analysis of chemistry and/or fluid samples comprising a rotatable disk-like body, a plurality of receptacles for fluid samples and optics for guiding light beams through the receptacles are arranged. At least part of the optics are designed and/or arranged such that at least part of the light beams is deflected and guided through the receptacles at an angle to the radially outward direction on the disk-like body which means at an angle to the radius, connecting the respective optics with the rotation axis of the disk-like body.
摘要翻译： 在用于对包括可旋转的盘状体的化学和/或流体样品进行光度分析的分析装置上，布置了多个用于流体样品的容器和用于将光束引导通过容器的光学器件。 光学元件的至少一部分被设计和/或布置成使得至少部分光束被偏转并且引导通过插座与盘状主体上的径向向外方向成一定角度，这意味着与半径成一定角度 将各光学元件与盘状体的旋转轴连接。
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公开(公告)号：US20080108910A1
公开(公告)日：2008-05-08
申请号：US11868505
申请日：2007-10-07
申请人： Heinz-Michael Hein , Reto Abt , Stephan Korner , Irio Calasso , Emad Sarofim , Patrick Griss , Rainer Jaeggi
发明人： Heinz-Michael Hein , Reto Abt , Stephan Korner , Irio Calasso , Emad Sarofim , Patrick Griss , Rainer Jaeggi
CPC分类号： A61B5/150503 , A61B5/0531 , A61B5/150022 , A61B5/150068 , A61B5/150167 , A61B5/150175 , A61B5/150358 , A61B5/150435 , A61B5/15107 , A61B5/15117 , A61B5/15123 , A61B5/15186
摘要： The present invention provides a method and a device for piercing a body part and determining whether a sufficient volume of blood has been withdrawn. A lancing element is rapidly inserted into a body part in a forward phase and retracted quickly to a lesser puncturing depth. Subsequently, the lancing element is retracted slower than during the first retraction movement and the distance retracted during the second retraction is shorter than the first retraction movement. During the second retraction movement, body fluid is collected in a collection phase by a capillary structure of the lancing element. Contact between the lancing element and the body fluid is detected after the forward phase at the beginning and the end of a waiting period.
摘要翻译： 本发明提供一种用于刺穿身体部位并确定是否已经抽出了足够体积的血液的方法和装置。 穿刺元件迅速地插入到前部的身体部位并且迅速地缩回到较小的穿刺深度。 随后，穿刺元件缩回比在第一缩回运动期间慢，并且在第二缩回期间缩回的距离比第一缩回运动短。 在第二回缩运动期间，体液通过穿刺元件的毛细结构收集在收集阶段。 在等待期开始和结束后的前进阶段之后检测穿刺元件与体液之间的接触。
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