公开(公告)号：US20070293478A1

公开(公告)日：2007-12-20

申请号：US11655589

申请日：2007-01-19

Applicant: Holger Zimmermann ,  Rudolph Schohe-loop ,  Kerstin Henninger ,  Daniela Paulsen ,  Thomas Roelle ,  Dieter Lang ,  Kai Thede ,  Chantal Fuerstner ,  David Brueckner ,  Johannes Koebberling ,  Marcus Bauser

Inventor： Holger Zimmermann ,  Rudolph Schohe-loop ,  Kerstin Henninger ,  Daniela Paulsen ,  Thomas Roelle ,  Dieter Lang ,  Kai Thede ,  Chantal Fuerstner ,  David Brueckner ,  Johannes Koebberling ,  Marcus Bauser

IPC: A61K31/497 ,  A61K31/5377 ,  A61K31/5513 ,  A61P31/22 ,  C07D243/08 ,  C07D401/02 ,  C07D413/14

CPC classification number: C07D215/56 ,  C07D401/04

Abstract: The invention relates to substituted quinolones and to processes for their preparation as well as to their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses.

Abstract translation: 本发明涉及取代的喹诺酮及其制备方法，以及它们用于生产用于治疗和/或预防疾病的药物的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的药物。

公开(公告)号：US20100022527A1

公开(公告)日：2010-01-28

申请号：US12392844

申请日：2009-02-25

Applicant: Dirk HEIMBACH ,  Adrian TERSTEEGEN ,  Kai THEDE ,  Reinhold WELKER ,  Beate FAST ,  Arnold PAESSENS ,  Frank DITTMER ,  Rudolph SCHOHE-LOOP ,  Axel HARRENGA ,  Alexander HILLISCH ,  Kerstin HENNINGER ,  Walter HUEBSCH ,  Marcus BAUSER ,  Daniela PAULSEN ,  Alexander BIRKMANN ,  Thomas BRETSCHNEIDER ,  Reiner FISCHER ,  Susanne GRESCHAT ,  Andreas URBAN ,  Steffen WILDUM

Inventor： Dirk HEIMBACH ,  Adrian TERSTEEGEN ,  Kai THEDE ,  Reinhold WELKER ,  Beate FAST ,  Arnold PAESSENS ,  Frank DITTMER ,  Rudolph SCHOHE-LOOP ,  Axel HARRENGA ,  Alexander HILLISCH ,  Kerstin HENNINGER ,  Walter HUEBSCH ,  Marcus BAUSER ,  Daniela PAULSEN ,  Alexander BIRKMANN ,  Thomas BRETSCHNEIDER ,  Reiner FISCHER ,  Susanne GRESCHAT ,  Andreas URBAN ,  Steffen WILDUM

IPC: A61K31/5377 ,  C07D491/10 ,  A61K31/438 ,  C07D413/12 ,  C07D307/94 ,  A61K31/34 ,  A61P31/12 ,  A61P31/18

CPC classification number: C07D307/94 ,  C07D405/12 ,  C07D407/10 ,  C07D491/10 ,  C07D493/10 ,  C07D495/10

Abstract: The present invention relates to novel substituted spirotetronic acids (I) in which R1 and R2, together with the carbon atom to which they are bonded, form a group of the formula (1), (2), (3) or (4), whereby * represents the carbon atom to which R1 and R2 are bonded, to methods for their preparation, their use for the treatment and/or prophylaxis of diseases, as well as their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of retroviral disorders, in people and/or animals.

Abstract translation: 本发明涉及新的取代的spirotetronic酸（I），其中R 1和R 2与它们所连接的碳原子一起形成式（1），（2），（3）或（4）的基团， ，其中*表示R1和R2键合的碳原子，其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防的药物的用途 的疾病，特别是逆转录病毒疾病，在人和/或动物中。