公开(公告)号：US20100261759A1

公开(公告)日：2010-10-14

申请号：US12665718

申请日：2008-06-07

Applicant: Swen Allerheiligen ,  Marcus Bauser ,  Hartmut Schirok ,  Ulrich Rester ,  Stefan Heitmeier ,  Christoph Gerdes ,  Georges Von Degenfeld ,  Elke Dittrich-Wengenroth ,  Uwe Saatman ,  Julia Strassburger ,  Klaus Münter ,  Mark Jean Gnoth ,  Dieter Lang

Inventor： Swen Allerheiligen ,  Marcus Bauser ,  Hartmut Schirok ,  Ulrich Rester ,  Stefan Heitmeier ,  Christoph Gerdes ,  Georges Von Degenfeld ,  Elke Dittrich-Wengenroth ,  Uwe Saatman ,  Julia Strassburger ,  Klaus Münter ,  Mark Jean Gnoth ,  Dieter Lang

IPC: A61K31/4439 ,  C07D413/14 ,  A61P7/02

CPC classification number: C07D413/14

Abstract: The invention relates to novel substituted oxazolidinones, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of thromboembolic disorders.

公开(公告)号：US20080194598A1

公开(公告)日：2008-08-14

申请号：US11886289

申请日：2006-03-07

Applicant: Elisabeth Woltering ,  Arounarith Tuch ,  Elke Dittrich-Wengenroth ,  Axel Kretschmer ,  Lars Barfacker ,  Marcus Bauser ,  Peter Ellinghaus ,  Klemens Lustig ,  Elisabeth Pook ,  Olaf Weber

Inventor： Elisabeth Woltering ,  Arounarith Tuch ,  Elke Dittrich-Wengenroth ,  Axel Kretschmer ,  Lars Barfacker ,  Marcus Bauser ,  Peter Ellinghaus ,  Klemens Lustig ,  Elisabeth Pook ,  Olaf Weber

IPC: A61K31/513 ,  C07D239/34 ,  C07D239/26 ,  A61K31/505 ,  A61P9/10

CPC classification number: C07D239/28 ,  C07D239/34

Abstract: The present application relates to pyrimidinecarboxylic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders, in particular dyslipidaemias and arteriosclerosis.

Abstract translation: 本申请涉及嘧啶羧酸衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/或 预防心血管疾病，特别是血脂异常和动脉硬化。

公开(公告)号：US20080261990A1

公开(公告)日：2008-10-23

申请号：US11663813

申请日：2005-09-10

Applicant: Elke Dittrich-Wengenroth ,  Lars Barfacker ,  Axel Kretschmer ,  Claudia Hirth-Dietrich ,  Peter Ellinghaus ,  Martin Raabe ,  Hilmar Bischoff ,  Christian Pilger ,  Ulrich Rosentreter ,  Stephan Bartel ,  Klemens Lustig ,  Armin Kern ,  Dieter Lang ,  Marcus Bauser

Inventor： Elke Dittrich-Wengenroth ,  Lars Barfacker ,  Axel Kretschmer ,  Claudia Hirth-Dietrich ,  Peter Ellinghaus ,  Martin Raabe ,  Hilmar Bischoff ,  Christian Pilger ,  Ulrich Rosentreter ,  Stephan Bartel ,  Klemens Lustig ,  Armin Kern ,  Dieter Lang ,  Marcus Bauser

IPC: A61K31/496 ,  C07D405/12 ,  A61K31/506 ,  C07D239/28 ,  A61K31/505

CPC classification number: C07D239/42 ,  C07D405/12

Abstract: The present invention relates to novel pyrimidine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular diseases, in particular dyslipidemias, arteriosclerosis, coronary heart disease, thrombosis and metabolic syndrome.

Abstract translation: 本发明涉及新颖的嘧啶衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/ 或预防心血管疾病，特别是血脂异常，动脉硬化，冠心病，血栓形成和代谢综合征。

公开(公告)号：US20060264432A1

公开(公告)日：2006-11-23

申请号：US11359927

申请日：2006-02-21

Applicant: Ulrich Rosentreter ,  Rolf Henning ,  Marcus Bauser ,  Thomas Kramer ,  Andrea Vaupel ,  Walter Hubsch ,  Klaus Dembowsky ,  Olga Salcher-Schraufstatter ,  Johannes-Peter Stasch ,  Thomas Krahn ,  Elisabeth Perzborn

Inventor： Ulrich Rosentreter ,  Rolf Henning ,  Marcus Bauser ,  Thomas Kramer ,  Andrea Vaupel ,  Walter Hubsch ,  Klaus Dembowsky ,  Olga Salcher-Schraufstatter ,  Johannes-Peter Stasch ,  Thomas Krahn ,  Elisabeth Perzborn

IPC: A61K31/5377 ,  A61K31/496 ,  A61K31/4545 ,  A61K31/4439 ,  C07D413/02 ,  C07D403/02 ,  C07D401/02

CPC classification number: C07D401/12 ,  C07D213/85 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: The invention relates to compounds of general formula (I), a method for the production thereof and the use thereof as pharmacologically effective substances for a broad medical indication spectrum. Furthermore, selective adenosine receptor ligands, preferably selective adenosine A1-, adenosine A2a- and/or adenosine A2b-receptor ligands are provided for the prophylaxis and/or the treatment of diseases, especially cardiovascular diseases, diseases of the urogenital region, diseases of the respiratory tract, inflammatory and neuroinflammatory diseases, diabetes, especially pancreatic diabetes, neurodegenerative diseases, pain states, cancer as well as liver fibrosis and liver cirrhosis.

公开(公告)号：US07135486B1

公开(公告)日：2006-11-14

申请号：US10110284

申请日：2000-09-19

Applicant: Ulrich Rosentreter ,  Rolf Henning ,  Marcus Bauser ,  Thomas Krämer ,  Andrea Vaupel ,  Walter Hübsch ,  Klaus Dembowsky ,  Olga Salcher-Schraufstätter ,  Johannes-Peter Stasch ,  Thomas Krahn ,  Elisabeth Perzborn

Inventor： Ulrich Rosentreter ,  Rolf Henning ,  Marcus Bauser ,  Thomas Krämer ,  Andrea Vaupel ,  Walter Hübsch ,  Klaus Dembowsky ,  Olga Salcher-Schraufstätter ,  Johannes-Peter Stasch ,  Thomas Krahn ,  Elisabeth Perzborn

IPC: C07D213/85 ,  A61K31/44

CPC classification number: C07D401/12 ,  C07D213/85 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: This application relates to compounds of formula (I), wherein R1, R2, R3, and R4 are defined as recited in the claims, or a tautomer, salt, hydrate, or alkoxide thereof. A process for preparing such materials, pharmaceutical compositions containing them, and methods of treating a cardiovascular disorder by administering them to a patient are also disclosed and claimed.

Abstract translation: 本申请涉及式（I）化合物，其中R 1，R 2，R 3和R 4， SUP>如权利要求中所定义，或其互变异构体，盐，水合物或醇盐。 还公开并要求保护制备这种材料的方法，含有它们的药物组合物，以及通过将它们给予患者来治疗心血管疾病的方法。

公开(公告)号：US08198267B2

公开(公告)日：2012-06-12

申请号：US12665728

申请日：2008-06-13

Applicant: Swen Allerheiligen ,  Marcus Bauser ,  Hartmut Schirok ,  Michael Härter ,  Stephan Siegel ,  Ulrich Rester ,  Christoph Gerdes ,  Stefan Heitmeier ,  Georges Von Degenfeld ,  Anja Buchmüller ,  Elke Dittrich-Wengenroth ,  Uwe Saatman ,  Julia Strassburger ,  Mark Jean Gnoth ,  Dieter Lang

Inventor： Swen Allerheiligen ,  Marcus Bauser ,  Hartmut Schirok ,  Michael Härter ,  Stephan Siegel ,  Ulrich Rester ,  Christoph Gerdes ,  Stefan Heitmeier ,  Georges Von Degenfeld ,  Anja Buchmüller ,  Elke Dittrich-Wengenroth ,  Uwe Saatman ,  Julia Strassburger ,  Mark Jean Gnoth ,  Dieter Lang

IPC: C07D413/14 ,  A61K31/4439 ,  A61P7/02

CPC classification number: C07D413/14

Abstract: The invention relates to novel substituted oxazolidinones, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases, and to the use thereof for producing medicaments for treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.

Abstract translation: 本发明涉及新型取代的恶唑烷酮，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。

公开(公告)号：US20110172207A1

公开(公告)日：2011-07-14

申请号：US12884113

申请日：2010-09-16

Applicant: Rudolf SCHOHE-LOOP ,  Reinhold Welker ,  Arnold Paessens ,  Marcus Bauser ,  Friederike Stoll ,  Frank Dittmer ,  Kerstin Henninger ,  Daniela Paulsen ,  Dieter Lang

Inventor： Rudolf SCHOHE-LOOP ,  Reinhold Welker ,  Arnold Paessens ,  Marcus Bauser ,  Friederike Stoll ,  Frank Dittmer ,  Kerstin Henninger ,  Daniela Paulsen ,  Dieter Lang

IPC: A61K31/4155 ,  C07D413/06 ,  C07D403/06 ,  C07D417/06 ,  A61K31/5377 ,  A61K31/553 ,  A61K31/427 ,  A61K31/5386 ,  A61K31/541 ,  A61K31/496 ,  A61P31/12 ,  A61P31/18

CPC classification number: C07D231/14 ,  A61K31/4155 ,  C07D401/06 ,  C07D403/06 ,  C07D413/06 ,  C07D417/06 ,  C07D451/06 ,  C07D491/08 ,  C07D498/08

Abstract: The present invention relates to novel substituted pyrazolamides, methods for their preparation, their use for the treatment and/or prophylaxis of diseases, as well as their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of retroviral diseases, in humans and/or animals.

Abstract translation: 本发明涉及新型取代的吡唑啉酰胺，其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防疾病尤其是逆转录病毒疾病的药物的用途 ，在人类和/或动物中。

公开(公告)号：US20100298293A1

公开(公告)日：2010-11-25

申请号：US12665728

申请日：2008-06-13

Applicant: Swen Allerheiligen ,  Marcus Bauser ,  Hartmut Schirok ,  Michael Härter ,  Stephan Siegel ,  Ulrich Rester ,  Christoph Gerdes ,  Stefan Heitmeier ,  Georges Von Degenfeld ,  Anja Buchmüller ,  Elke Dittrich-Wengenroth ,  Uwe Saatman ,  Julia Strassburger ,  Mark Jean Gnoth ,  Dieter Lang

Inventor： Swen Allerheiligen ,  Marcus Bauser ,  Hartmut Schirok ,  Michael Härter ,  Stephan Siegel ,  Ulrich Rester ,  Christoph Gerdes ,  Stefan Heitmeier ,  Georges Von Degenfeld ,  Anja Buchmüller ,  Elke Dittrich-Wengenroth ,  Uwe Saatman ,  Julia Strassburger ,  Mark Jean Gnoth ,  Dieter Lang

IPC: A61K31/553 ,  A01N1/02 ,  A61K31/5377 ,  A61K31/497 ,  A61K31/513 ,  A61K31/454 ,  A61K31/4439 ,  C07D413/12 ,  A61P7/02

CPC classification number: C07D413/14

Abstract: The invention relates to novel substituted oxazolidinones, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases, and to the use thereof for producing medicaments for treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.

Abstract translation: 本发明涉及新型取代的恶唑烷酮，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。

公开(公告)号：US20100184740A1

公开(公告)日：2010-07-22

申请号：US12665729

申请日：2008-06-07

Applicant: Swen Allerheiligen ,  Marcus Bauser ,  Dirk Heimbach ,  Stefan Heitmeier ,  Mark Jean Gnoth ,  Christoph Gerdes ,  Georges Von Degenfeld ,  Susanne Röhrig ,  Ulrich Rester ,  Elke Dittrich-Wengenroth ,  Uwe Saatman ,  Adrian Tersteegen

Inventor： Swen Allerheiligen ,  Marcus Bauser ,  Dirk Heimbach ,  Stefan Heitmeier ,  Mark Jean Gnoth ,  Christoph Gerdes ,  Georges Von Degenfeld ,  Susanne Röhrig ,  Ulrich Rester ,  Elke Dittrich-Wengenroth ,  Uwe Saatman ,  Adrian Tersteegen

IPC: A61K31/4439 ,  C07D413/14 ,  A61K31/5377 ,  A61K31/496 ,  C07D417/14 ,  A61K31/541 ,  A61K31/553 ,  A61P7/02 ,  A61P7/00 ,  A61P9/12 ,  A61P29/00

CPC classification number: C07D413/14

Abstract: The invention relates to novel substituted oxazolidinones, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of thromboembolic disorders.

Abstract translation: 本发明涉及新的取代的恶唑烷酮，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。

公开(公告)号：US20070293478A1

公开(公告)日：2007-12-20

申请号：US11655589

申请日：2007-01-19

Applicant: Holger Zimmermann ,  Rudolph Schohe-loop ,  Kerstin Henninger ,  Daniela Paulsen ,  Thomas Roelle ,  Dieter Lang ,  Kai Thede ,  Chantal Fuerstner ,  David Brueckner ,  Johannes Koebberling ,  Marcus Bauser

Inventor： Holger Zimmermann ,  Rudolph Schohe-loop ,  Kerstin Henninger ,  Daniela Paulsen ,  Thomas Roelle ,  Dieter Lang ,  Kai Thede ,  Chantal Fuerstner ,  David Brueckner ,  Johannes Koebberling ,  Marcus Bauser

IPC: A61K31/497 ,  A61K31/5377 ,  A61K31/5513 ,  A61P31/22 ,  C07D243/08 ,  C07D401/02 ,  C07D413/14

CPC classification number: C07D215/56 ,  C07D401/04

Abstract: The invention relates to substituted quinolones and to processes for their preparation as well as to their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses.

Abstract translation: 本发明涉及取代的喹诺酮及其制备方法，以及它们用于生产用于治疗和/或预防疾病的药物的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的药物。