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公开(公告)号：US20070020383A1
公开(公告)日：2007-01-25
申请号：US11527610
申请日：2006-09-27
申请人： Kazuhisa Matsuda , Yukihiro Morinaga , Ryosuke Kamimura , Nobutoshi Doi , Toshifumi Hotta , Tsunehiro Nagata , Koji Shimizu , Yoshiteru Nakano
发明人： Kazuhisa Matsuda , Yukihiro Morinaga , Ryosuke Kamimura , Nobutoshi Doi , Toshifumi Hotta , Tsunehiro Nagata , Koji Shimizu , Yoshiteru Nakano
CPC分类号： A61L31/044 , A61B17/06166 , A61L27/24 , A61L27/48 , A61L31/10 , Y10T442/20 , Y10T442/2525 , Y10T442/2762 , Y10T442/614 , Y10T442/643 , Y10T442/646 , Y10T442/659 , Y10T442/696 , C08L5/08 , C08L89/06
摘要： An adhesion preventive membrane including a nonwoven fabric layer of collagen fibers, having on a surface thereof a coating layer containing a mixture of collagen and hyaluronic acid, or a method of producing a continuous collagen single strand, wherein a strand-like collagen is dehydrated/coagulated in a hydrophilic organic solvent having a water content of about 10% or less and then dried under conditions of a relative humidity of about 50% or less and a temperature of about 42° C. or less. A collagen nonwoven fabric of first and second layers composed of a plurality of collagen strand-like materials spun out of a solubilized collagen solution, and arranged in parallel, the first and second layers being laminated and bonded to each other so that directions of arrangements of the strand-like materials of the first and the second layers are at an angle therebetween.
摘要翻译： 一种粘合防止膜，其包含胶原纤维的无纺布层，其表面上具有含有胶原和透明质酸的混合物的涂层，或者连续的胶原单股的制造方法，其中，将线状胶原脱水/ 在具有约10％或更低的水含量的亲水性有机溶剂中凝结，然后在约50％或更低的相对湿度和约42℃或更低的温度的条件下干燥。 一种胶原无纺织物，其由多个胶原线状材料组成，由溶解的胶原溶液纺出，并且平行布置，所述第一和第二层彼此层叠并粘合，使得所述第一和第二层的布置方向 第一层和第二层的股线状材料之间成角度。
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2.发明申请公开(公告)号：US20070009585A1
公开(公告)日：2007-01-11
申请号：US11481098
申请日：2006-07-06
CPC分类号： A61L15/325 , A61L27/24 , Y10T442/2525 , Y10T442/646
摘要： In order to provide a substrate for medical applications, which may be freely elastically deformed depending on a shape of a defective portion or hemostasis portion in a living body, is biocompatible and suitable for tissue regeneration or cell proliferation, or hemostasis, and can be easily manufactured. A collagen substrate of the present invention includes a three-dimensional mesh formed of spun collagen filaments. Preferably, the collagen substrate of the present invention includes cotton formed of spun collagen filaments.
摘要翻译： 为了提供可根据生物体中的缺陷部分或止血部分的形状而自由弹性变形的医疗用途的基材，是生物相容的，适用于组织再生或细胞增殖或止血，并且可以容易地 制造。 本发明的胶原基质包括由旋转的胶原纤维形成的三维网状物。 优选地，本发明的胶原基质包括由旋转的胶原纤维形成的棉花。
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3.发明授权公开(公告)号：US07456118B2
公开(公告)日：2008-11-25
申请号：US11481098
申请日：2006-07-06
IPC分类号： D04H1/00
CPC分类号： A61L15/325 , A61L27/24 , Y10T442/2525 , Y10T442/646
摘要： In order to provide a substrate for medical applications, which may be freely elastically deformed depending on a shape of a defective portion or hemostasis portion in a living body, is biocompatible and suitable for tissue regeneration or cell proliferation, or hemostasis, and can be easily manufactured. A collagen substrate of the present invention includes a three-dimensional mesh formed of spun collagen filaments. Preferably, the collagen substrate of the present invention includes cotton formed of spun collagen filaments.
摘要翻译： 为了提供可根据生物体中的缺陷部分或止血部分的形状而自由弹性变形的医疗用途的基材，是生物相容的，适用于组织再生或细胞增殖或止血，并且可以容易地 制造。 本发明的胶原基质包括由旋转的胶原纤维形成的三维网状物。 优选地，本发明的胶原基质包括由旋转的胶原纤维形成的棉花。
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4.发明申请Biodegradable substrate, prosthetic material for tissue regeneration, and cultured tissue 审中-公开可生物降解的基质，用于组织再生的辅助材料和培养的组织公开(公告)号：US20060029639A1
公开(公告)日：2006-02-09
申请号：US10533307
申请日：2003-10-29
IPC分类号： A61F2/00
CPC分类号： B32B5/06 , A61L27/24 , A61L27/3804 , B32B5/18 , B32B5/24 , B32B5/245 , B32B2307/7163 , B32B2535/00
摘要： A biodegradable substrate usable as a prosthetic material (i.e., for tissue regeneration) facilitates the invasion of cells into a substrate and has a thick structure similar to woven fabrics. The biodegradable substrate is obtained by stitching a biodegradable nonwoven fabric with a biodegradable thread. An embodiment of the nonwoven fabric used is a material wherein first and second layers, each having filaments of a thread made of collagen located in parallel, are laminated and adhered to each other so that the alignment direction of the filaments of the thread in the first and second layer are arranged at a certain angle. This nonwoven fabric is stitched with a thread made of collagen. In another embodiment a filmy material having been treated with a biodegradable binder such as collagen or gelatin is piled on the nonwoven fabric and stitched.
摘要翻译： 可用作假体材料（即用于组织再生）的可生物降解的底物有利于细胞侵入基质并具有类似织造织物的厚结构。 生物降解性基材通过将生物降解性无纺布与生物降解性线缝合而得到。 所使用的无纺织物的一个实施例是一种材料，其中每个具有由胶原定位的线的丝线并联的第一和第二层彼此层压并粘合，使得第一和第二层中的线的长丝的排列方向 并且第二层以一定角度排列。 该无纺布用胶原线缝合。 在另一个实施方案中，已经用可生物降解的粘合剂如胶原或明胶处理的薄膜材料堆积在无纺织物上并被缝合。
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公开(公告)号：US20050129570A1
公开(公告)日：2005-06-16
申请号：US11002486
申请日：2004-12-03
摘要： A method of sterilizing a biocompatible material with which decomposition and deterioration in a process of radiation sterilization can be suppressed by hermetically wrapping the biocompatible material together with a deoxidizer with a nonbreathable wrapping material and subjecting the resultant to radiation sterilization. The method suppresses decomposition and deterioration of the material in a process of radiation sterilization. More particularly, the method can reduce the effects of decomposition and deterioration on decomposition time of the biocompatible material in living organisms.
摘要翻译： 对生物相容性材料进行灭菌的方法，通过使用不透气的包装材料与脱氧剂一起将生物相容性材料密封包裹，并对所得物进行辐射灭菌，可以抑制辐射灭菌过程中的分解和劣化。 该方法抑制辐射灭菌过程中材料的分解和劣化。 更具体地说，该方法可以降低活生物体中生物相容性物质的分解和劣化对分解时间的影响。
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6.发明申请Antiadhesive Kit, Process for Producing the Same and Method of Adhesion Prevention 审中-公开防粘剂套件，生产方法和粘合防止方法公开(公告)号：US20080241203A1
公开(公告)日：2008-10-02
申请号：US10594801
申请日：2005-03-31
IPC分类号： A61K9/00 , A61K31/728 , A61K38/39 , A61K38/17
CPC分类号： A61L31/148
摘要： An adhesion preventive kit and a method of preventing adhesion are provided which have a preventive effect on adhesion in a surrounding part of an edge of an injured or deficient tissue in guided regeneration therapy for an injured tissue. Specifically, the adhesion preventive kit includes: (A) a first membrane of at least two layers having a biodegradable base layer and an adhesion preventive layer provided respectively at outermost surfaces thereof and a second membrane of at least one layer having an adhesion preventive layer provided at an outermost surface thereof, or (B) an adhesion preventive membrane including a biodegradable base layer and an adhesion preventive layer, which membrane has an outermost surface constituted of the adhesion preventive layer and has a tissue sandwiching part.
摘要翻译： 提供了一种防粘连剂和防止粘合的方法，其对受伤组织的引导再生治疗中对损伤组织或缺损组织的边缘的周围部分的粘附具有预防作用。 具体而言，粘合防止用具包括：（A）具有生物降解性基底层的至少两层的第一膜和分别在其最表面设置的防粘附层，和具有防粘层的至少一层的第二膜， 或（B）具有可生物降解性底层和防粘附层的防粘连膜，该膜具有由防粘附层构成的最外表面，并且具有组织夹持部。
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