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公开(公告)号：US20110015121A1
公开(公告)日：2011-01-20
申请号：US12922337
申请日：2009-03-13
摘要： A compound useful as an antifungal agent, particularly a therapeutic agent for deep-seated mycoses, is provided. A fungus Acremonium persicinum was collected, and cyclic compounds were isolated from culture liquids thereof. The present inventors confirmed that the cyclic compounds or salts thereof have a potent antifungal activity and are useful as medicaments, particularly an antifungal agent, and thus the present invention was completed. The cyclic compound and the salt thereof according to the present invention can be used as an agent for preventing or treating mycoses, particularly deep-seated mycoses.
摘要翻译： 提供了可用作抗真菌剂的化合物，特别是用于深层真菌病的治疗剂。 收集真菌Acremonium persicinum，从其培养液中分离出环状化合物。 本发明人证实，环状化合物或其盐具有有效的抗真菌活性，可用作药物，特别是抗真菌剂，因此完成了本发明。 根据本发明的环状化合物及其盐可用作预防或治疗真菌病，特别是深层真菌病的药剂。
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公开(公告)号：US08598115B2
公开(公告)日：2013-12-03
申请号：US12922337
申请日：2009-03-13
摘要： A compound useful as an antifungal agent, particularly a therapeutic agent for deep-seated mycoses, is provided. A fungus Acremonium persicinum was collected, and cyclic compounds were isolated from culture liquids thereof. The present inventors confirmed that the cyclic compounds or salts thereof have a potent antifungal activity and are useful as medicaments, particularly an antifungal agent, and thus the present invention was completed. The cyclic compound and the salt thereof according to the present invention can be used as an agent for preventing or treating mycoses, particularly deep-seated mycoses.
摘要翻译： 提供了可用作抗真菌剂的化合物，特别是用于深层真菌病的治疗剂。 收集真菌Acremonium persicinum，从其培养液中分离出环状化合物。 本发明人证实，环状化合物或其盐具有有效的抗真菌活性，可用作药物，特别是抗真菌剂，因此完成了本发明。 根据本发明的环状化合物及其盐可用作预防或治疗真菌病，特别是深层真菌病的药剂。
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公开(公告)号：US08241872B2
公开(公告)日：2012-08-14
申请号：US12922675
申请日：2009-03-13
摘要： A microorganism which produces compounds useful as an antifungal agent, particularly a therapeutic agent for deep-seated mycoses, such as mycotic sinusitis, is provided. The present inventors have conducted intensive studies on naturally-occurring microorganisms as a research for antifungal compounds, and found a fungus Acremonium persicinum which produces cyclic compounds having a potent antifungal activity and useful as a medicament, particularly an antifungal agent, and the present invention was completed.
摘要翻译： 提供了产生用作抗真菌剂的化合物的微生物，特别是用于深层真菌病的治疗剂如真菌性鼻窦炎。 本发明人对天然存在的微生物进行了深入研究，作为抗真菌化合物的研究，并发现了一种产生具有有效抗真菌活性的环状化合物的真菌（Acremonium persicinum），可用作药物，特别是抗真菌剂，本发明是 完成
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公开(公告)号：US06399567B1
公开(公告)日：2002-06-04
申请号：US09308218
申请日：1999-06-16
申请人： Ryuichi Kanasaki , Shigehiro Takase , Michizane Hashimoto , Hiroshi Hatanaka , Kazutoshi Sakamoto , Seiji Hashimoto , Nobuyuki Shiraishi , Hidenori Ohki , Kohji Kawabata
发明人： Ryuichi Kanasaki , Shigehiro Takase , Michizane Hashimoto , Hiroshi Hatanaka , Kazutoshi Sakamoto , Seiji Hashimoto , Nobuyuki Shiraishi , Hidenori Ohki , Kohji Kawabata
IPC分类号： A61K3812
摘要： This invention relates to new polypeptide compounds represented by the following formula (I): wherein R1 is as defined in the description or a salt thereof which have antimicrobial activities (especially, antifungal activities), inhibitory activity on &bgr;-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prophylactic and/or therapeutic treatment of infectious disease including Pneumocystis carinii infection (e.g., Pneumocystis carinii pneumonia) in a human being or an animal.
摘要翻译： 本发明涉及由下式（I）表示的新多肽化合物：其中R1如说明书中所定义或其具有抗微生物活性（特别是抗真菌活性）的盐，对β-1,3-葡聚糖合酶的抑制活性， 涉及其制备方法，包含其的药物组合物，以及用于预防和/或治疗人或动物中包括卡氏肺囊虫感染（例如卡氏肺囊虫肺炎）的感染性疾病的方法。
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公开(公告)号：US20110020872A1
公开(公告)日：2011-01-27
申请号：US12922675
申请日：2009-03-13
摘要： A microorganism which produces compounds useful as an antifungal agent, particularly a therapeutic agent for deep-seated mycoses, such as mycotic sinusitis, is provided. The present inventors have conducted intensive studies on naturally-occurring microorganisms as a research for antifungal compounds, and found a fungus Acremonium persicinum which produces cyclic compounds having a potent antifungal activity and useful as a medicament, particularly an antifungal agent, and the present invention was completed.
摘要翻译： 提供了产生用作抗真菌剂的化合物的微生物，特别是用于深层真菌病的治疗剂如真菌性鼻窦炎。 本发明人对天然存在的微生物进行了深入研究，作为抗真菌化合物的研究，发现了一种产生具有有效抗真菌活性的环状化合物的真菌（Acremonium persicinum），可用作药物，特别是抗真菌剂，本发明是 完成
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