Antibodies to &agr;v&bgr;3 integrin
    6.
    发明授权
    Antibodies to &agr;v&bgr;3 integrin 失效
    抗体为alphavbeta3整合素

    公开(公告)号:US06369204B1

    公开(公告)日:2002-04-09

    申请号:US09560743

    申请日:2000-04-28

    IPC分类号: C12P2108

    摘要: The invention relates to monoclonal antibodies to the &agr;v&bgr;3 integrin receptor known to be expressed in large amounts on the surface of osteoclasts and accordingly, associated with bone resorption. The disclosed monoclonal antibodies are believed to recognize unique epitopes on &agr;v&bgr;3 and are useful in the treatment of conditions associated with excessive bone resorption and/or in the inhibition of tumor cell growth.

    摘要翻译: 本发明涉及已知在破骨细胞表面上大量表达的α受体α整联蛋白受体的单克隆抗体,因此与骨吸收有关。 据信所公开的单克隆抗体识别出在α2β3上的独特表位,并且可用于治疗与过量骨吸收和/或抑制肿瘤细胞生长相关的病症。