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    A SAMPLE HANDLING DEVICE
    1.
    发明申请
    A SAMPLE HANDLING DEVICE 审中-公开
    样品处理装置

    公开(公告)号：US20150377747A1

    公开(公告)日：2015-12-31

    申请号：US14766758

    申请日：2014-02-10

    Applicant: Sirma CAPAR DINCER

    Inventor： Sirma CAPAR DINCER

    IPC: G01N1/20 ,  C12Q1/24

    CPC classification number: G01N1/20 ,  C12Q1/24 ,  G01N1/12

    Abstract: Sample handling device which enables to take samples (samples of living beings) from single celled invertebrate living beings which live in different depths of aqueous mediums such as lakes, ponds, barrages and sea shore zones. The aim is to take samples from vertebrate living beings which live by attaching themselves on living beings or non living materials such as plants, stones and shells in aqueous medium such as lakes, ponds, barrages and shore zones. Another aim is to present the medium where single cell living beings live and to carry such living beings to the laboratory in order to examine them.

    Abstract translation: 能够从生活在不同深度的水介质如湖泊，池塘，拦河坝和海岸带的单细胞无脊椎动物身上取样（生物样本）的样品处理装置。 目的是通过在诸如湖泊，池塘，堰坝和岸区的水介质中附着在生物或非生物材料如植物，石头和贝壳上的脊椎动物生物进行采样。 另一个目标是提供单细胞生物居住的媒介，并将这种生物携带到实验室进行检查。

    AGENTS FOR TREATING FLAVIVIRIDAE INFECTIONS
    2.
    发明申请
    AGENTS FOR TREATING FLAVIVIRIDAE INFECTIONS 审中-公开
    用于治疗感冒的药剂

    公开(公告)号：US20100135966A1

    公开(公告)日：2010-06-03

    申请号：US12624271

    申请日：2009-11-23

    Applicant: Ulrich Schubert ,  Hans Will ,  Hüseyin Sirma

    Inventor： Ulrich Schubert ,  Hans Will ,  Hüseyin Sirma

    IPC: A61K35/12 ,  A61K31/40 ,  A61K31/336

    CPC classification number: A61K31/69 ,  A61K31/11 ,  A61K31/16 ,  A61K38/06

    Abstract: The invention relates to agents for the treatment, therapy and inhibition of Flaviviridae virus infections, which agents comprise proteasome inhibitors as the active component. The agents which are used for inhibiting the release, maturation and replication of Flaviviridae comprise, as the active component in pharmaceutical preparations, substance classes which share the common property of inhibiting the 26S proteasome in cells. These substance classes include, in particular, proteasome inhibitors which affect the activities of the ubiquitin/proteasome pathway, in particular the enzymic activities of the 26S and the 20S proteasome complex. The application of the invention lies in the antiviral therapy of Flaviviridae infections, especially in preventing the establishment and maintenance of a chronic hepatitis C virus infection and a hepatopathogenesis which is associated therewith.

    Abstract translation: 本发明涉及用于治疗，治疗和抑制黄病毒科病毒感染的药剂，该药物包含作为活性成分的蛋白酶体抑制剂。 用于抑制黄病毒科的释放，成熟和复制的药物包含作为药物制剂中的活性成分的具有抑制细胞中26S蛋白酶体的共同性质的物质类别。 这些物质类别特别包括影响泛素/蛋白酶体途径的活性的蛋白酶体抑制剂，特别是26S和20S蛋白酶体复合物的酶活性。 本发明的应用在于黄病毒科感染的抗病毒治疗，特别是在预防慢性丙型肝炎病毒感染的建立和维持以及与之相关的肝癌发病。

    Beta-L-nucleosides and use thereof as pharmaceutical agents for the treatment of viral diseases
    3.
    发明申请
    Beta-L-nucleosides and use thereof as pharmaceutical agents for the treatment of viral diseases 审中-公开
    β-L-核苷及其用作治疗病毒性疾病的药剂

    公开(公告)号：US20060217345A1

    公开(公告)日：2006-09-28

    申请号：US11373062

    申请日：2006-03-10

    Applicant: Eckart Matthes ,  Martin Janta-Lipinski ,  Hans Will ,  Huseyin Sirma ,  Lin Li

    Inventor： Eckart Matthes ,  Martin Janta-Lipinski ,  Hans Will ,  Huseyin Sirma ,  Lin Li

    IPC: A61K31/7072 ,  A61K31/675 ,  A61K31/513 ,  C07H19/04 ,  C07H19/12 ,  C07F9/6512

    CPC classification number: C07H19/06 ,  C07H19/09

    Abstract: Nucleoside analogs, nucleic acids and pharmaceutical agents comprising same, and to the use of said nucleoside analogs, nucleic acids and pharmaceutical agents in the diagnosis, prophylaxis or therapy of a viral, bacterial, fungicidal and/or parasitic infection, or of cancer, particularly of hepatitis infections. The invention also relates to a method for the preparation of said nucleoside analogs and to a kit and the use thereof in the prophylaxis and therapy of viral diseases, particularly of hepatitis infections. As stated in 37 C.F.R. §1.72(b): A brief abstract of the technical disclosure in the specification must commence on a separate sheet, preferably following the claims, under the heading “Abstract of the Disclosure.” The purpose of the abstract is to enable the Patent and Trademark Office and the public generally to determine quickly from a cursory inspection the nature and gist of the technical disclosure. The abstract shall not be used for interpreting the scope of the claims. Therefore, any statements made relating to the abstract are not intended to limit the claims in any manner and should not be interpreted as limiting the claims in any manner.

    Abstract translation: 核苷类似物，核酸和包含其的药物，以及所述核苷类似物，核酸和药物在诊断，预防或治疗病毒，细菌，杀真菌和/或寄生虫感染或癌症中的用途，特别是 的肝炎感染。 本发明还涉及制备所述核苷类似物和试剂盒的方法及其用于预防和治疗病毒性疾病，特别是肝炎感染的用途。 如37 C.F.R. §1.72（b）：说明书中技术性披露的简要摘要必须在单独的表格上开始，优选按照权利要求，在“披露摘要”标题下。 摘要的目的是使专利商标局和公众一般能够从粗略检查中快速确定技术披露的性质和要点。 摘要不得用于解释权利要求的范围。 因此，与摘要有关的任何陈述不旨在以任何方式限制权利要求，也不应被解释为以任何方式限制权利要求。

    Modular support for carrying ceramic products during baking
    4.
    发明授权
    Modular support for carrying ceramic products during baking 失效
    在烘烤期间承载陶瓷产品的模块化支持

    公开(公告)号：US3877869A

    公开(公告)日：1975-04-15

    申请号：US42363273

    申请日：1973-12-10

    Applicant: SIRMA

    Inventor： PALAZZO FERDINANDO

    IPC: F27D5/00 ,  F27B21/04

    CPC classification number: F27D5/0012

    Abstract: A support formed of modular elements made of refractory material. Each modular element is a rectangular case open at both ends and having horizontally extending teeth projecting from the inner and outer faces of two vertical sides. The teeth are adapted to carry horizontal plates upon which products to be baked are supported while the support moves through a furnace. Plate-like interconnecting elements are provided for assembling the modular elements.

    Abstract translation: 由耐火材料制成的模块化元件形成的支撑件。 每个模块化元件是在两端敞开的矩形壳体，并且具有从两个垂直侧面的内表面和外表面突出的水平延伸的齿。 这些齿适用于承载水平板，当支撑件移动通过炉子时，待加工的产品被支撑在其上。 提供板状互连元件用于组装模块化元件。

    Suspended crowns of industrial furnaces, and refractory elements for making such crowns
    6.
    发明授权
    Suspended crowns of industrial furnaces, and refractory elements for making such crowns 失效
    工业炉的悬挂冠和用于制造这种冠的耐火元件

    公开(公告)号：US3877402A

    公开(公告)日：1975-04-15

    申请号：US44942474

    申请日：1974-03-08

    Applicant: SIRMA

    Inventor： PALAZZO FERDINANDO

    IPC: F23M5/06 ,  F27D1/02 ,  F23M5/02

    CPC classification number: F27D1/021 ,  F23M5/06

    Abstract: A suspended crown of an industrial furnace formed of anchored refractory bricks, additional refractory bricks, and refractory plates. The anchored bricks are formed at one end with means for engaging hooks which secure the bricks to support beams, and at their opposite ends with shoulders for carrying the refractory plates. The sides of the anchored and additional bricks are formed with teeth which mesh with teeth in adjacent bricks. The plates are generally rectangular and provided with parallel channels for reducing their weight.

    Abstract translation: 由固定的耐火砖，附加耐火砖和耐火板组成的工业炉的悬挂冠。 锚固砖在一端形成有用于接合钩的装置，其将砖固定成支撑梁，并且在其相对端具有用于承载耐火板的肩部。 锚固和附加砖的侧面形成有与相邻砖块中的齿啮合的齿。 板通常是矩形的，并且具有用于减小它们的重量的平行通道。

    Agents for treating <I>flaviviridae</I>infections
    8.
    发明申请
    Agents for treating flaviviridaeinfections 审中-公开
    用于治疗黄病毒感染的药剂

    公开(公告)号：US20050203029A1

    公开(公告)日：2005-09-15

    申请号：US10510355

    申请日：2003-04-04

    Applicant: Ulrich Schubert ,  Hans Will ,  Huseyin Sirma

    Inventor： Ulrich Schubert ,  Hans Will ,  Huseyin Sirma

    IPC: A61K31/11 ,  A61K31/16 ,  A61K31/69 ,  A61K38/06 ,  A61P31/12 ,  A61K31/366 ,  A61K38/04

    CPC classification number: A61K31/69 ,  A61K31/11 ,  A61K31/16 ,  A61K38/06

    Abstract: The invention relates to agents for the treatment, therapy and inhibition of Flaviviridae virus infections, which agents comprise proteasome inhibitors as the active component. The agents which are used for inhibiting the release, maturation and replication of Flaviviridae comprise, as the active component in pharmaceutical preparations, substance classes which share the common property of inhibiting the 26S proteasome in cells. These substance classes include, in particular, proteasome inhibitors which affect the activities of the ubiquitin/proteasome pathway, in particular the enzymic activities of the 26S and the 20S proteasome complex. The application of the invention lies in the antiviral therapy of Flaviviridae infections, especially in preventing the establishment and maintenance of a chronic hepatitis C virus infection and a hepatopathogenesis which is associated therewith.

    Abstract translation: 本发明涉及用于治疗，治疗和抑制黄病毒科病毒感染的药剂，该药物包含作为活性成分的蛋白酶体抑制剂。 用于抑制黄病毒科的释放，成熟和复制的药物包含作为药物制剂中的活性成分的具有抑制细胞中26S蛋白酶体的共同性质的物质类别。 这些物质类别特别包括影响泛素/蛋白酶体途径的活性的蛋白酶体抑制剂，特别是26S和20S蛋白酶体复合物的酶活性。 本发明的应用在于黄病毒科感染的抗病毒治疗，特别是在预防慢性丙型肝炎病毒感染的建立和维持以及与之相关的肝癌发病。

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