公开(公告)号：US20180161571A1

公开(公告)日：2018-06-14

申请号：US15894541

申请日：2018-02-12

Applicant: SORIN CRM S.A.S.

Inventor： Jean-François Ollivier

IPC: A61N1/05 ,  A61N1/372 ,  A61N1/375

CPC classification number: A61N1/0573 ,  A61N1/056 ,  A61N1/0565 ,  A61N1/37205 ,  A61N1/37518 ,  A61N1/3756 ,  A61N2001/058

Abstract: An assembly including an autonomous capsule having an anchoring member adapted to penetrate tissue of the heart and an accessory for implantation of the capsule. The accessory includes a steerable catheter with an inner lumen, having at its distal end a tubular protection tip defining a volume for housing the capsule. The accessory also includes a disconnectable attachment mechanism for supporting and guiding the capsule to an implantation site and a sub-catheter housed within the lumen of the steerable catheter, moveable in translation and in rotation relative to the steerable catheter. The sub-catheter and the capsule are movable between a retracted position and a position wherein the capsule is deployed out of the protection tip. The sub-catheter and the capsule are provided with a first fastening mechanism for fastening the two in translation and in mutual rotation, which is disconnectable under a rotation applied to the sub-catheter.

公开(公告)号：US09265929B2

公开(公告)日：2016-02-23

申请号：US13895974

申请日：2013-05-16

Applicant: SORIN CRM S.A.S

Inventor： Jean-François Ollivier ,  Nicolas Shan ,  Philippe D'Hiver

IPC: A61N1/05 ,  A61N1/372

CPC classification number: A61N1/05 ,  A61B2562/125 ,  A61N1/0534 ,  A61N1/056 ,  A61N1/372 ,  Y10T29/49117

Abstract: A method of manufacturing a detection/stimulation lead for implantation into a venous, arterial, or lymphatic network is shown and described. The method includes providing a microcable comprising a sheath of insulating material covering an electrically conductive core. The method further includes surrounding a portion of the microcable with an electrically conductive metal ring. The method also includes crimping the ring such that the thickness of the sheath is penetrated by a portion of the metal ring and such that an electrical connection is formed between the metal ring and the electrically conductive core.

Abstract translation: 显示和描述了用于植入静脉，动脉或淋巴网络的检测/刺激引线的制造方法。 该方法包括提供包括覆盖导电芯的绝缘材料的护套的微电缆。 该方法还包括用导电金属环包围微电缆的一部分。 该方法还包括压接环，使得护套的厚度被金属环的一部分穿透，并且使得在金属环和导电芯之间形成电连接。

公开(公告)号：US09248271B2

公开(公告)日：2016-02-02

申请号：US14079298

申请日：2013-11-13

Applicant: SORIN CRM S.A.S.

Inventor： Willy Régnier ,  Nicolas Shan

IPC: A61N1/00 ,  A61N1/05

CPC classification number: A61N1/05 ,  A61N1/057

Abstract: A microlead includes exposed areas forming stimulation electrodes. The microlead further includes a stimulation zone (ZS) defined by a first preshape of the microcable at the distal end thereof, in a region including the electrodes (30). The microlead further includes a retention zone (ZR) including a retainer shape adapted to abut the wall of the target vessel. The microlead further includes a stretching zone (ZEL) proximal to the retention zone. The stretching zone may be defined by a shape adapted to make the region elastically deformable in the longitudinal direction under the effect of an axial traction/compression stress. The axial traction/compression stiffness in the elongation zone is lower than that in the retention and stimulation areas.

Abstract translation: 微孔包括形成刺激电极的暴露区域。 所述微引线还包括在包括所述电极（30）的区域中由所述微电极在其远端处的第一预塑膜限定的刺激区（ZS）。 微针还包括保持区（ZR），其包括适于邻接目标血管壁的保持器形状。 微珠还包括靠近保留区的拉伸区（ZEL）。 拉伸区域可以由适于使区域在轴向牵引/压缩应力的作用下在纵向方向上弹性变形的形状来限定。 延伸区域的轴向牵引/压缩刚度低于保留和刺激区域。

公开(公告)号：US09089711B2

公开(公告)日：2015-07-28

申请号：US13942596

申请日：2013-07-15

Applicant: SORIN CRM S.A.S.

Inventor： Lionel Giorgis ,  Amel Amblard

IPC: A61N1/00 ,  A61N1/37 ,  G06K9/00 ,  A61N1/39 ,  A61N1/365

CPC classification number: A61N1/3702 ,  A61N1/36578 ,  A61N1/371 ,  A61N1/3925 ,  G06K9/00536

Abstract: A processor-based method for use with an active implantable medical device for cardiac pacing, resynchronization, and/or defibrillation includes forming a plurality of first and second endocardial acceleration vectors using a plurality of endocardial acceleration signals acquired using stimulation to cause capture and a spontaneous rhythm of the patient in the absence of ventricular pacing, respectively. An at least two dimension space is created using the first and second endocardial acceleration vectors, including two subspaces corresponding to the presence and absence of capture, respectively. Ventricular capture is tested for after acquiring a new endocardial acceleration signal. The testing includes forming a new endocardial acceleration signal based on the new vector. Presence or absence of capture is determined for the new signal based on the position of the new vector relative to the two subspaces.

Abstract translation: 用于心脏起搏，再同步和/或除颤的主动植入医疗装置的基于处理器的方法包括使用多次使用刺激获得的心内加速度信号形成多个第一和第二心内膜加速度矢量以引起捕获和自发 分别在不存在心室起搏的情况下患者的节律。 使用第一和第二心内膜加速度矢量创建至少两个维度空间，其包括分别对应于存在和不存在捕获的两个子空间。 在获得新的心内膜加速度信号后测试心室捕获。 该测试包括基于新向量形成新的心内膜加速度信号。 基于新矢量相对于两个子空间的位置，确定新信号的存在或不存在。

公开(公告)号：US09083161B2

公开(公告)日：2015-07-14

申请号：US14034366

申请日：2013-09-23

Applicant: SORIN CRM S.A.S.

Inventor： Bertrand Boutaud ,  Hélène Viatgé

IPC: H02G3/22 ,  H02G3/02 ,  A61N1/375

CPC classification number: H02G3/02 ,  A61N1/3754 ,  H01G4/35 ,  Y10T29/49155 ,  Y10T29/49162 ,  Y10T29/49165

Abstract: A method for making an hermetic and electrically insulating feedthrough in the metal wall of a housing of a device, preferably of an active medical device, is disclosed. The method includes: a) forming electrically insulating layers (24, 26) on each of the internal and external sides of the wall (10), b) on the internal side of the wall, forming a non-through groove with a closed contour (30) defining in the wall a metal islet (28) that is physically and electrically isolated from the rest of the wall, by removing the entire thickness of the electrically insulating internal layer (26) and the wall (10), leaving intact a sufficient thickness of the electrically insulating external layer (24) so that the external layer mechanically supports the metal islet, and c) on the external and internal sides respectively, exposing pads (34, 36) for making an electrical contact to the metallic islet, by a localized removal of material of the electrically insulating external and internal layers (24, 26), respectively.

Abstract translation: 公开了一种用于在装置的壳体的金属壁中制造气密和电绝缘馈通的方法，优选地为主动医疗装置。 该方法包括：a）在壁的内侧上的壁（10）的内侧和外侧的每一侧上形成电绝缘层（24,26），b）形成具有封闭轮廓的非贯通槽 （30），通过去除所述电绝缘内层（26）和所述壁（10）的整个厚度，在所述壁中限定与所述壁的其余部分物理和电隔离的金属岛（28），从而保持完整 电绝缘外层（24）的足够的厚度使得外层机械地支撑金属岛，以及c）分别在外侧和内侧，用于与金属岛形成电接触的暴露焊盘（34,36） 通过分别去除电绝缘的外层和内层（24,26）的材料。

公开(公告)号：US09037262B2

公开(公告)日：2015-05-19

申请号：US14059152

申请日：2013-10-21

Applicant: Sorin CRM S.A.S.

Inventor： Willy Regnier ,  Martin Deterre ,  Patrice Poussin

IPC: A61N1/00 ,  A61N1/05 ,  A61N1/375 ,  A61N1/365

CPC classification number: A61N1/059 ,  A61N1/0587 ,  A61N1/36585 ,  A61N1/37518 ,  A61N1/3752 ,  A61N1/3756

Abstract: An intracorporeal autonomous active medical device having a capsule body and a base. The capsule body includes a body portion and a lid portion, and the capsule body contains therein electronic circuitry containing the active elements of the autonomous medical device, and a power supply. The capsule body also includes a fastening system on an exterior surface of the capsule body that is configured to correspond with a fastening mechanism on the base configured to be anchored to a tissue wall. The fastening mechanism provides selective engagement between the capsule body and the base.

Abstract translation: 一种具有胶囊主体和基部的体内自主主动医疗装置。 胶囊主体包括主体部分和盖部分，并且胶囊主体包含其中包含自主医疗装置的有源元件的电子电路和电源。 胶囊主体还包括在胶囊主体的外表面上的紧固系统，其被构造成与构造成锚固到组织壁的基部上的紧固机构对应。 紧固机构提供胶囊主体和底座之间的选择性接合。

公开(公告)号：US09014822B2

公开(公告)日：2015-04-21

申请号：US13960640

申请日：2013-08-06

Applicant: Sorin CRM S.A.S.

Inventor： Jean-François Ollivier

IPC: A61N1/05

CPC classification number: A61N1/0587 ,  A61N1/056 ,  A61N1/0573 ,  A61N2001/0585

Abstract: A pacing lead for a left cavity of the heart, implanted in the coronary system. This lead (24) includes a lead body with a hollow sheath (26, 28) of deformable material, having a central lumen open at both ends, and at least one telescopic microcable (42) of conductive material. The microcable slides along the length of the lead body and extends beyond the distal end (32) thereof. The party emerging beyond the distal end is an active free part (34) comprising a plurality of distinct bare areas (36, 38, 50, 50′, 50″), intended to come into contact (40) with the wall of a target vein (22) of the coronary system (14-22), so as to form a network of stimulation electrodes electrically connected together in parallel. The microcable further comprises, proximally, a connector to a generator of active implantable medical device such as a pacemaker or a resynchronizer.

Abstract translation: 心脏左腔的起搏线，植入冠状动脉系统。 该引线（24）包括具有可变形材料的中空护套（26,28）的引线本体，其具有在两端敞开的中心管腔和至少一个导电材料的可伸缩微电缆（42）。 微型可滑动件沿着引线体的长度滑动并且延伸超出其远端（32）。 出现在远端之外的派对是主动的自由部分（34），其包括多个不同的裸露区域（36,38,50,50'，50“），其旨在与目标的壁接触（40） 静脉（22），以形成并联电连接在一起的刺激电极网络。 微型电缆还包括近端地连接到主动植入式医疗装置（例如起搏器或再同步器）的发生器。

公开(公告)号：US20150005838A1

公开(公告)日：2015-01-01

申请号：US14484415

申请日：2014-09-12

Applicant: SORIN CRM S.A.S.

Inventor： Fabrizio Renesto ,  Lionel Giorgis

IPC: A61N1/365

CPC classification number: A61N1/36578 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3686 ,  A61N1/3706

Abstract: An implantable medical device includes a sensor configured to generate an endocardial acceleration (EA) signal representative of activity of a patient's heart. The device further includes one or more circuits configured to identify within the EA signal at least one EA signal component corresponding to at least one peak of endocardial acceleration, and extract from the at least one EA signal component at least two characteristic parameters. The one or more circuits are further configured to generate a composite index based on a combination of the at least two characteristic parameters, determine a plurality of values of the composite index for a plurality of pacing configurations, and select a current pacing configuration from among the plurality of pacing configurations based on the plurality of values of the composite index.

Abstract translation: 可植入医疗装置包括被配置为产生代表患者心脏活动的心内加速度（EA）信号的传感器。 该装置还包括一个或多个电路，其被配置为在EA信号内识别与至少一个心内膜加速度峰值对应的至少一个EA信号分量，并从至少一个EA信号分量提取至少两个特征参数。 所述一个或多个电路还被配置为基于所述至少两个特征参数的组合来生成复合索引，确定多个起搏配置的复合索引的多个值，并且从所述多个起搏配置中选择当前起搏配置 基于复合索引的多个值的多个起搏配置。

公开(公告)号：US20140378991A1

公开(公告)日：2014-12-25

申请号：US14312381

申请日：2014-06-23

Applicant: SORIN CRM S.A.S.

Inventor： Jean-François Ollivier

IPC: A61N1/05

CPC classification number: A61N1/0573 ,  A61N1/056 ,  A61N1/0565 ,  A61N1/37205 ,  A61N1/37518 ,  A61N1/3756 ,  A61N2001/058

Abstract: An assembly including an autonomous capsule having an anchoring member adapted to penetrate tissue of the heart and an accessory for implantation of the capsule. The accessory includes a steerable catheter with an inner lumen, having at its distal end a tubular protection tip defining a volume for housing the capsule. The accessory also includes a disconnectable attachment mechanism for supporting and guiding the capsule to an implantation site and a sub-catheter housed within the lumen of the steerable catheter, moveable in translation and in rotation relative to the steerable catheter. The sub-catheter and the capsule are movable between a refracted position and a position wherein the capsule is deployed out of the protection tip. The sub-catheter and the capsule are provided with a first fastening mechanism for fastening the two in translation and in mutual rotation, which is disconnectable under a rotation applied to the sub-catheter.

Abstract translation: 一种组件，包括具有适于穿透心脏组织的锚定构件的自主胶囊和用于植入胶囊的附件。 附件包括具有内腔的可导向导管，其远端具有限定用于容纳胶囊的体积的管状保护尖端。 附件还包括可拆卸的连接机构，用于将胶囊支撑并引导到植入部位，以及容纳在可操纵导管的内腔内的副导管，可相对于可转向导管平移和旋转移动。 副导管和胶囊可在折射位置和胶囊从保护尖端部署出的位置之间移动。 子导管和胶囊设置有第一紧固机构，用于将两者平移和相互旋转紧固，其在施加到副导管的旋转下可断开。

公开(公告)号：US20140378854A1

公开(公告)日：2014-12-25

申请号：US14479901

申请日：2014-09-08

Applicant: SORIN CRM S.A.S.

Inventor： Paola Milpied ,  Christine Henry

IPC: A61N1/39 ,  A61B5/0452 ,  A61B5/04

CPC classification number: A61N1/3987 ,  A61B5/04012 ,  A61B5/0452 ,  A61B5/0464 ,  A61N1/3962

Abstract: A single-chamber implantable device for detecting a patient's atrial activity using a monobody lead is disclosed. The monobody lead (10) includes a ventricular coil (16), a supraventricular coil (18), a distal electrode (14) forming three electrodes for detecting depolarization signals. A generator (12) of the implantable device collects a first unipolar signal (20) between the ventricular coil and the generator housing and a second unipolar signal (22) between the supraventricular coil and the generator housing. An independent component analysis is performed to the detected depolarization signals to determine an estimated atrial activity signal from the first and second unipolar signals.

Abstract translation: 公开了一种用于使用单体引线检测患者的心房活动的单室可植入装置。 单体引线（10）包括心室线圈（16），室上线圈（18），形成用于检测去极化信号的三个电极的远端电极（14）。 可植入装置的发生器（12）收集心室线圈和发电机壳体之间的第一单极信号（20）和在室上线圈和发电机壳体之间的第二单极信号（22）。 对检测到的去极化信号执行独立分量分析，以确定来自第一和第二单极信号的估计的心房活动信号。