公开(公告)号：US10918725B2

公开(公告)日：2021-02-16

申请号：US15762165

申请日：2016-09-30

Applicant: SAMJIN PHARMACEUTICAL CO., LTD.

Inventor： Eui-Hwan Cho ,  Sung-Ju Choi ,  Sung-Woo Lee ,  Hee-Jong Shin ,  Min-Hyo Ki ,  Mee-Hwa Choi ,  Dong-Ha Lee

IPC: A61K47/40 ,  A61K9/48 ,  A61K9/08 ,  A61K31/4704 ,  A61K47/02 ,  A61K47/10 ,  A61K47/18 ,  A61K47/22 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61K9/00 ,  A61K47/44

Abstract: An ophthalmic composition is provided that includes rebamipide and a method for preparing the same. The ophthalmic composition of maintains its transparency for a long time even in a physiologically neutral to weakly basic pH range that does not injure the cornea and conjunctiva of a patient suffering from dry eye and has improved stability so as not to be re-dispersed.

公开(公告)号：US20230025836A1

公开(公告)日：2023-01-26

申请号：US17756266

申请日：2020-11-20

Applicant: Samjin Pharmaceutical Co., Ltd. ,  AptaBio Therapeutics Inc.

Inventor： Min-hyo Ki ,  Jin-cheul Kim ,  Mee-Hwa Choi ,  Dong-Ha Lee ,  Sung Hwan Moon ,  Soo Jin Lee

IPC: A61K31/4155 ,  A61K9/00 ,  A61P27/02

Abstract: The present invention relates to an ophthalmic preparation containing an active ingredient selected from 3-phenyl-4-propyl-1-(pyridin-2-yl)-1H-pyrazol-5-ol compound or a pharmaceutically acceptable salt thereof. The eye drop according to the present invention is excellent in stability and safety and shows an excellent effect on prevention or treatment of eye diseases in such a way that an active ingredient thereof reaches a posterior segment of an eyeball simply through instillation rather than a direct injection into an eyeball.