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    HUMAN CORNEAL ENDOTHELIAL CELL-DERIVED PRECURSOR CELLS, CELLULAR AGGREGATES, METHODS FOR MANUFACTURING THE SAME, AND METHODS FOR TRANSPLANTING PRECURSOR CELLS AND CELLULAR AGGREGATES
    3.
    发明申请
    HUMAN CORNEAL ENDOTHELIAL CELL-DERIVED PRECURSOR CELLS, CELLULAR AGGREGATES, METHODS FOR MANUFACTURING THE SAME, AND METHODS FOR TRANSPLANTING PRECURSOR CELLS AND CELLULAR AGGREGATES 审中-公开
    人角膜内皮细胞衍生的前列腺细胞，细胞聚集体，其制备方法以及用于转运前列腺细胞和细胞聚集体的方法

    公开(公告)号：US20090232772A1

    公开(公告)日：2009-09-17

    申请号：US11721300

    申请日：2005-12-02

    申请人： Shiro Amano ,  Satoru Yamagami ,  Tatsuya Mimura ,  Yasuhiro Osakabe

    发明人： Shiro Amano ,  Satoru Yamagami ,  Tatsuya Mimura ,  Yasuhiro Osakabe

    IPC分类号： A61K45/00 ,  C12N5/08 ,  A61P27/02

    CPC分类号： A61K35/44 ,  A61K35/12 ,  A61L27/3808 ,  A61L27/3839 ,  A61L2430/16 ,  C12N5/0621

    摘要： Providing is cellular aggregates derived from corneal endothelial cells that, when transplanted, readily adhere to the parenchyma of cornea and function in a manner equivalent to corneal endothelial cells, and a method of transplantation of the cellular aggregates. Cellular aggregates derived from corneal endothelial cells. The cellular aggregates derived from corneal endothelial cells is prepared by culturing human corneal endothelial cells in a medium containing fetal bovine serum, growth factor and glucose; and then float culturing the cells obtained in a medium containing growth factor. A method of transplantation into the anterior chamber the cellular aggregate or the cellular aggregate prepared by the above method, comprising inserting a tube into the parenchyma of cornea, introducing the cellular aggregate into the anterior chamber through the inserted tube, and causing the cellular aggregate that has been introduced to adhere to Descemet's membrane by assuming in a downward-facing position.

    摘要翻译： 提供衍生自角膜内皮细胞的细胞聚集体，当被移植时，容易地粘附到角膜的薄壁组织并以与角膜内皮细胞相当的方式起作用，以及移植细胞聚集体的方法。 衍生自角膜内皮细胞的细胞聚集体。 衍生自角膜内皮细胞的细胞聚集体通过在含有胎牛血清，生长因子和葡萄糖的培养基中培养人角膜内皮细胞来制备; 然后漂浮培养在含有生长因子的培养基中获得的细胞。 一种通过上述方法移植到前房中的细胞聚集体或细胞聚集体的方法，包括将管插入角膜的薄壁组织，通过插入的管将细胞聚集体引入前房，并使细胞聚集体 已经被引入到坚持Descemet的膜，假设在向下的位置。