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    Use of lipid conjugates in the treatment of diseases
    1.
    发明授权
    Use of lipid conjugates in the treatment of diseases 有权
    使用脂质偶联物治疗疾病

    公开(公告)号：US08383787B2

    公开(公告)日：2013-02-26

    申请号：US13031990

    申请日：2011-02-22

    申请人： Saul Yedgar

    发明人： Saul Yedgar

    IPC分类号： C07H5/04

    CPC分类号： C08B37/0069 ,  A61K31/728 ,  A61K31/737 ,  A61K47/544 ,  A61K47/61 ,  C08B37/0072

    摘要： This invention provides compounds represented by the structure of the general formula (A): wherein L is a lipid or a phospholipid, Z is either nothing, ethanolamine, serine, inositol, choline, or glycerol, Y is either nothing or a spacer group ranging in length from 2 to 30 atoms, X is a physiologically acceptable monomer, dimer, oligomer, or polymer, wherein X is a glycosaminoglycan; and n is a number from 1 to 1000, wherein any bond between L, Z, Y and X is either an amide or an esteric bond.

    摘要翻译： 本发明提供由通式（A）的结构表示的化合物：其中L为脂质或磷脂，Z为无，乙醇胺，丝氨酸，肌醇，胆碱或甘油，Y为无或间隔基范围 长度为2至30个原子，X为生理上可接受的单体，二聚体，低聚物或聚合物，其中X为糖胺聚糖; n为1〜1000的数，L，Z，Y和X之间的任意键为酰胺键或酯键。

    USE OF LIPID CONJUGATES IN THE TREATMENT OF DISEASES
    2.
    发明申请
    USE OF LIPID CONJUGATES IN THE TREATMENT OF DISEASES 有权
    在治疗疾病中使用脂质偶联物

    公开(公告)号：US20100317591A1

    公开(公告)日：2010-12-16

    申请号：US12820161

    申请日：2010-06-22

    申请人： Saul Yedgar

    发明人： Saul Yedgar

    IPC分类号： A61K31/726 ,  A61K31/728 ,  A61K31/737 ,  A61K31/727 ,  A61P17/00 ,  A61P17/06 ,  A61P17/08 ,  A61P29/00

    CPC分类号： A61K47/544

    摘要： This invention provides a method of treating a subject suffering from a dermatologic condition, including, inter alia, psoriasis, contact dermatitis, and seboreic dermatitis, the method includes the step of administering to a subject a compound comprising a lipid or phospholipid moiety bound to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof, in an amount effective to treat the subject suffering from a dermatologic condition.

    摘要翻译： 本发明提供了一种治疗患有皮肤病症状的个体的方法，其中包括尤其是牛皮癣，接触性皮炎和皮脂炎性皮炎，所述方法包括向受试者施用包含与 生理上可接受的单体，二聚体，低聚物或聚合物，和/或其药学上可接受的盐或其药物产品，其量有效地治疗患有皮肤病学病症的受试者。

    Use of lipid conjugates in the treatment of disease
    3.
    发明授权
    Use of lipid conjugates in the treatment of disease 有权

    公开(公告)号：US07034006B2

    公开(公告)日：2006-04-25

    申请号：US09756765

    申请日：2001-01-10

    申请人： Saul Yedgar ,  David Shuseyov ,  Gershon Golomb ,  Reuven Reich ,  Isaac Ginsburg ,  Abd-al-Roof Higazi ,  Moshe Ligumski ,  Miron Krimsky ,  David Ojcius ,  Benito Antonio Yard ,  Fokko Johannes van der Woude ,  Edit Schnitzer

    发明人： Saul Yedgar ,  David Shuseyov ,  Gershon Golomb ,  Reuven Reich ,  Isaac Ginsburg ,  Abd-al-Roof Higazi ,  Moshe Ligumski ,  Miron Krimsky ,  David Ojcius ,  Benito Antonio Yard ,  Fokko Johannes van der Woude ,  Edit Schnitzer

    IPC分类号： A61K31/70 ,  A61K31/715 ,  C08B37/08 ,  C08B37/10 ,  C07H5/06

    CPC分类号： A61K47/544

    摘要： The invention provides novel methods for treating disease based upon the medicinal use of lipids and phospholipids covalently bound to physiologically acceptable monomers or polymers. Phosphatidylethanolamine moieties conjugated to physiologically acceptable monomers and polymers (PE conjugates) manifest an unexpectedly wide range of pharmacological effects, including stabilizing cell membranes; limiting oxidative damage to cell and blood components; limiting cell proliferation, cell extravasation and (tumor) cell migratory behavior; suppressing immune responses; and attenuating physiological reactions to stress, as expressed in elevated chemokine levels. The surprisingly manifold pharmacological properties of the PL-conjugates allow for the invention, disclosed herein, of novel methods for the treatment of a diverse range of disease states, including obstructive respiratory disease, including asthma; colitis and Crohn's disease; central nervous system insult, including blood brain barrier compromise, ischemic stroke, and multiple sclerosis; contact dermatitis; psoriasis; cardiovascular disease, including ischemic conditions and prophylaxis for invasive vascular procedures; cellular proliferative disorders, including anti-tumor vasculogenesis, invasiveness, and metastases; anti-oxidant therapy; hemolytic syndromes; sepsis; acute respiratory distress syndrome; tissue transplant rejection syndromes; autoimmune disease; viral infection; and hypersensitivity conjunctivitis. The therapeutic methods of the invention include administration of phosphatidylethanolamine bound to carboxymethylcellulose, heparin, hyaluronic acid, polyethylene glycol, and hemaccel. Disclosed herein are also new compounds comprised of phospholipid moieties bound to low molecular weight monomers and dimers, including mono- and disaccharides, carboxylated disaccharides, mono- and dicarboxylic acids, salicylates, bile acids, and fatty acids.

    Use of lipid conjugates in the treatment of diseases
    4.
    发明申请
    Use of lipid conjugates in the treatment of diseases 失效
    使用脂质偶联物治疗疾病

    公开(公告)号：US20050203054A1

    公开(公告)日：2005-09-15

    申请号：US10952496

    申请日：2004-09-29

    申请人： Saul Yedgar

    发明人： Saul Yedgar

    IPC分类号： A61K31/685 ,  A61K31/715 ,  A61K31/727 ,  A61K31/737 ,  A61K31/739 ,  A61K38/16

    CPC分类号： A61K47/61 ,  A61K47/544

    摘要： This invention provides compounds represented by the structure of the general formula (A): wherein L is a lipid or a phospholipid, Z is either nothing, ethanolamine, serine, inositol, choline, or glycerol, Y is either nothing or a spacer group ranging in length from 2 to 30 atoms, X is a physiologically acceptable monomer, dimer, oligomer, or polymer, wherein X is a glycosaminoglycan; and n is a number from 1 to 1000, wherein any bond between L, Z, Y and X is either an amide or an esteric bond.

    摘要翻译： 本发明提供由通式（A）的结构表示的化合物：其中L为脂质或磷脂，Z为无，乙醇胺，丝氨酸，肌醇，胆碱或甘油，Y为无或间隔基范围 长度为2至30个原子，X为生理上可接受的单体，二聚体，低聚物或聚合物，其中X为糖胺聚糖; n为1〜1000的数，L，Z，Y和X之间的任意键为酰胺键或酯键。

    Liposomes comprising polymer-conjugated lipids and related uses
    6.
    发明授权
    Liposomes comprising polymer-conjugated lipids and related uses 有权

    公开(公告)号：US10179106B2

    公开(公告)日：2019-01-15

    申请号：US14115869

    申请日：2012-05-10

    申请人： Saul Yedgar

    发明人： Saul Yedgar

    IPC分类号： A61K9/127 ,  A61K31/713 ,  A61K47/48

    摘要： The present invention provides liposomes comprising a lipid bilayer and a polymer-conjugated lipid, wherein said polymer-conjugated lipid is incorporated into said lipid bilayer. The present invention also provides methods of producing the liposomes as well as a method of delivering a nucleic acid to a subject comprising the step of administering said nucleic acid encapsulated in a mixed liposome, a method for performing diagnostic imaging in a subject, comprising the step of administering a diagnostic agent encapsulated in a mixed liposome, and methods for treating, inhibiting, or suppressing a pathological condition in a subject comprising administering to said subject a mixed liposome.

    Use of lipid conjugates in the treatment of diseases of the nervous system
    7.
    发明授权
    Use of lipid conjugates in the treatment of diseases of the nervous system 有权
    使用脂质偶联物治疗神经系统疾病

    公开(公告)号：US09040078B2

    公开(公告)日：2015-05-26

    申请号：US10919523

    申请日：2004-08-17

    申请人： Saul Yedgar

    发明人： Saul Yedgar

    IPC分类号： A61K47/48

    CPC分类号： A61K47/48053 ,  A61K47/544

    摘要： The invention provides a method for treating a subject suffering from a disease of the central nervous system which is associated with an inflammatory response, including, inter alia, multiple sclerosis, Amyotrophic Lateral Sclerosis (ALS), meningitis, Alzheimer's disease, pain, HIV-associated dementia, stroke, traumatic brain injury, encephalomyelitis, chronic inflammatory demyelinating polyneuropathy, cerebral ischemia-induced injury or any combination thereof. This invention further provides for the use of a conjugate, or composition comprising the same, for treating the subject, wherein the conjugate comprises a lipid or phospholipid moiety bonded to a physiologically acceptable monomer, dimer, oligomer, or polymer.

    摘要翻译： 本发明提供了一种治疗患有与炎性反应相关的中枢神经系统疾病的受试者的方法，其特别包括多发性硬化症，肌萎缩性侧索硬化症（ALS），脑膜炎，阿尔茨海默病，疼痛，HIV- 相关的痴呆，中风，创伤性脑损伤，脑脊髓炎，慢性炎症性脱髓鞘性多发性神经病，脑缺血诱发的损伤或其任何组合。 本发明进一步提供了用于治疗受试者的缀合物或包含其的组合物的用途，其中所述缀合物包含与生理上可接受的单体，二聚体，低聚物或聚合物结合的脂质或磷脂部分。

    LIPID CONJUGATES IN THE TREATMENT OF ALLERGIC RHINITIS
    8.
    发明申请
    LIPID CONJUGATES IN THE TREATMENT OF ALLERGIC RHINITIS 有权
    脂肪酸联合治疗过敏性荨麻疹

    公开(公告)号：US20120083466A1

    公开(公告)日：2012-04-05

    申请号：US13316592

    申请日：2011-12-12

    申请人： Saul YEDGAR

    发明人： Saul YEDGAR

    IPC分类号： A61K31/715 ,  A61P37/08

    CPC分类号： A61K31/685 ,  A61K31/717 ,  A61K31/727 ,  A61K31/728

    摘要： Provided herein are methods of treating, suppressing, inhibiting, or preventing allergic rhinitis in a subject comprising the step of administering to a subject a compound comprising a lipid or phospholipid moiety bond to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof.

    摘要翻译： 本文提供了治疗，抑制或预防受试者的过敏性鼻炎的方法，包括向受试者施用包含脂质或磷脂部分键合到生理上可接受的单体，二聚体，低聚物或聚合物的化合物和/ 或其药学上可接受的盐或其药物产物。

    Use of lipid conjugates in the treatment of conjunctivitis
    9.
    发明授权
    Use of lipid conjugates in the treatment of conjunctivitis 失效
    使用脂质偶联物治疗结膜炎

    公开(公告)号：US07608598B2

    公开(公告)日：2009-10-27

    申请号：US11475240

    申请日：2006-06-27

    申请人： Saul Yedgar

    发明人： Saul Yedgar

    IPC分类号： A61K31/70

    CPC分类号： A61K31/737 ,  A61K31/685 ,  A61K31/717 ,  A61K31/721 ,  A61K31/727 ,  A61K31/728 ,  A61K47/543 ,  A61K47/544 ,  A61K47/61

    摘要： In one embodiment, the invention provides a method of suppressing, inhibiting, preventing, or treating conjunctivitis in a subject, comprising the step of administering an effective amount of a lipid or phospholipid moiety bound via an ester or amide bond to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof to a subject with conjunctivitis.

    摘要翻译： 在一个实施方案中，本发明提供抑制，预防或治疗受试者结膜炎的方法，其包括将有效量的通过酯或酰胺键结合的脂质或磷脂部分施用于生理上可接受的单体的步骤， 二聚体，低聚物或聚合物，和/或其药学上可接受的盐或药物产物。

    Use of lipid conjugates in the treatment of diseases or disorders of the eye
    10.
    发明申请
    Use of lipid conjugates in the treatment of diseases or disorders of the eye 有权
    使用脂质偶联物治疗眼睛疾病或病症

    公开(公告)号：US20080113935A1

    公开(公告)日：2008-05-15

    申请号：US11984223

    申请日：2007-11-14

    申请人： Saul Yedgar ,  Yuval Cohen

    发明人： Saul Yedgar ,  Yuval Cohen

    IPC分类号： A61K31/727 ,  A61K31/685 ,  A61K31/715 ,  A61K31/717 ,  A61P27/02 ,  A61K31/718 ,  A61K31/726

    CPC分类号： A61K31/661 ,  A61K9/0048 ,  A61K31/685 ,  A61K31/715 ,  A61K31/717 ,  A61K31/718 ,  A61K31/726 ,  A61K31/727 ,  A61K47/544 ,  A61K47/56 ,  A61K47/61 ,  Y02A50/401

    摘要： In one embodiment, the invention provides a method of treating, reducing the incidence, reducing the severity or pathogenesis of an eye disease or disorder in a subject, including, inter alia, retinal detachment, macular degeneration, glaucoma or retinopathy, comprising the step of administering an effective amount of a lipid or phospholipid moiety bound optionally via a spacer to a physiologically acceptable monomer, dimer, oligomer, or polymer via an ester or amide bond, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof. This invention also provides a contact lens solution comprising a lipid or phospholipid moiety bound optionally via a spacer to a physiologically acceptable monomer, dimer, oligomer, or polymer via an ester or amide bond, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof.

    摘要翻译： 在一个实施方案中，本发明提供了治疗，降低发病率，降低受试者眼睛疾病或病症的严重性或发病机理的方法，包括尤其是视网膜脱离，黄斑变性，青光眼或视网膜病变，包括以下步骤： 通过酯或酰胺键将有效量的任选地通过间隔基连接到生理上可接受的单体，二聚体，低聚物或聚合物的脂质或磷脂部分，和/或其药学上可接受的盐或药物产品。 本发明还提供一种隐形眼镜溶液，其包含通过间隔基任选地通过酯或酰胺键与生理学上可接受的单体，二聚体，低聚物或聚合物结合的脂质或磷脂部分和/或其药学上可接受的盐或其药物产物 。