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1.发明授权Engineered nucleic acids encoding a modified erythropoietin and their expression 有权编码改良促红细胞生成素的工程核酸及其表达公开(公告)号：US08710200B2
公开(公告)日：2014-04-29
申请号：US13437034
申请日：2012-04-02
Applicant: Jason P. Schrum , Noubar B. Afeyan , Gregory J. Sieczkiewicz , Stephane Bancel , Antonin de Fougerolles , Sayda M. Elbashir
Inventor： Jason P. Schrum , Noubar B. Afeyan , Gregory J. Sieczkiewicz , Stephane Bancel , Antonin de Fougerolles , Sayda M. Elbashir
CPC classification number: A61K47/18 , A61K31/7088 , A61K31/7115 , A61K38/193 , A61K38/4846 , A61K47/22 , A61K47/28 , A61K48/00 , C07K14/535 , C12N9/644 , C12N15/67 , C12N15/87 , C12N2310/335
Abstract: Provided are formulations, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the delivery of biological moieties, and are useful for production of proteins.
Abstract translation: 提供了将生物学部分如修饰的核酸递送到细胞中以调节蛋白质表达的制剂，组合物和方法。 这样的组合物和方法包括递送生物部分，并且可用于生产蛋白质。
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公开(公告)号：US20120237975A1
公开(公告)日：2012-09-20
申请号：US13252049
申请日：2011-10-03
Applicant: Jason Schrum , Gregory J. Sieczkiewicz , Kenechi Ejebe , Sayda M. Elbashir
Inventor： Jason Schrum , Gregory J. Sieczkiewicz , Kenechi Ejebe , Sayda M. Elbashir
CPC classification number: A61K48/0066 , C07H19/10 , C07H21/02 , C07K16/00 , C07K16/2887 , C07K2317/24 , C12N5/0602 , C12N15/102 , C12N15/11 , C12N15/1136 , C12N15/1138 , C12N15/67 , C12N2310/3341 , C12N2310/335 , C12P21/00 , G01N33/559
Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful for production of proteins.
Abstract translation: 提供了用于将生物学部分如修饰的核酸递送到细胞中以调节蛋白质表达的组合物和方法。 这样的组合物和方法包括使用修饰的信使RNA，并且可用于生产蛋白质。
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公开(公告)号：US20140147432A1
公开(公告)日：2014-05-29
申请号：US14105224
申请日：2013-12-13
Applicant: Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Susan Whoriskey , Sayda M. Elbashir
Inventor： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Susan Whoriskey , Sayda M. Elbashir
IPC: C12N9/64
CPC classification number: A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07K14/005 , C07K14/435 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/485 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/56 , C07K14/62 , C07K14/705 , C07K16/00 , C12N9/1051 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/644 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y304/21022 , C12Y603/02019
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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公开(公告)号：US20120251618A1
公开(公告)日：2012-10-04
申请号：US13437034
申请日：2012-04-02
Applicant: Jason P. Schrum , Noubar B. Afeyan , Gregory J. Sieczkiewicz , Stephane Bancel , Antonin de Fougerolles , Sayda M. Elbashir
Inventor： Jason P. Schrum , Noubar B. Afeyan , Gregory J. Sieczkiewicz , Stephane Bancel , Antonin de Fougerolles , Sayda M. Elbashir
IPC: A61K31/7105 , C07H21/02 , A61K9/127
CPC classification number: A61K47/18 , A61K31/7088 , A61K31/7115 , A61K38/193 , A61K38/4846 , A61K47/22 , A61K47/28 , A61K48/00 , C07K14/535 , C12N9/644 , C12N15/67 , C12N15/87 , C12N2310/335
Abstract: Provided are formulations, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the delivery of biological moieties, and are useful for production of proteins.
Abstract translation: 提供了将生物学部分如修饰的核酸递送到细胞中以调节蛋白质表达的制剂，组合物和方法。 这样的组合物和方法包括递送生物部分，并且可用于生产蛋白质。
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