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    Hydrophilic macromers and hydrogels comprising the same
    2.
    发明授权
    Hydrophilic macromers and hydrogels comprising the same 有权

    公开(公告)号：US10101499B2

    公开(公告)日：2018-10-16

    申请号：US14492722

    申请日：2014-09-22

    Applicant: Anubhav Saxena ,  Monjit Phukan ,  Shreedhar Bhat ,  Kenrick M. Lewis ,  Senthilkumar Umapathy

    Inventor： Anubhav Saxena ,  Monjit Phukan ,  Shreedhar Bhat ,  Kenrick M. Lewis ,  Senthilkumar Umapathy

    IPC: C08G77/20 ,  G02B1/04 ,  C08G77/46 ,  C08L83/04 ,  C08L83/08

    Abstract: A composition, suitable for use in producing hydrogel polymer films from which biomedical devices such as contact lenses can be made, comprising at least one hydrophilic silicone macromer. In one aspect, a hydrophilic silicone macromer is of the Formula 1: X—Si(R1)(R2)O—(Si(R3)(R4)O)a—Si(R5)(R6)—Y  (1) wherein R1, R2, R3 R4, R5 and R6 are independently selected from a monovalent linear, branched, or cyclic radical with 1 to 50 carbon atoms, that can optionally contain a heteroatom or I; I is RL—RP; Y is a free radical polymerization-effective hydrophilic group with the general structure: RL—RP—Z; RL is a linking residue from a non-isomerizable hydrosilylation effective terminal olefin comprising the general structure —CH2—C(RbR7)—(CR8R9)n, the subscript n is selected from integers from 1 to 10; R7, R8, and R9 can be selected from hydrogen and a mono-valent hydrocarbon radical with 1 to 10 carbon atoms that optionally contain a heteroatom; Rb is selected from a monovalent hydrocarbon radical with 1 to 6 carbon atoms; RP is a spacer group comprising a diavelant hydrophilic organic radical with 0 to 100 carbon atoms and optionally contains heteroatoms, and X is a free radical polymerizable group. The said composition can be polymers and films suitable for use in making contact lenses.

    HYDROPHILIC MACROMERS AND HYDROGELS COMPRISING THE SAME
    3.
    发明申请
    HYDROPHILIC MACROMERS AND HYDROGELS COMPRISING THE SAME 审中-公开
    水解胶体和包含其的水解胶

    公开(公告)号：US20150011667A1

    公开(公告)日：2015-01-08

    申请号：US14492722

    申请日：2014-09-22

    Applicant: Anubhav Saxena ,  Monjit Phukan ,  Shreedhar Bhat ,  Kenrick M. Lewis ,  Senthilkumar Umapathy

    Inventor： Anubhav Saxena ,  Monjit Phukan ,  Shreedhar Bhat ,  Kenrick M. Lewis ,  Senthilkumar Umapathy

    IPC: G02B1/04 ,  C08L83/08 ,  C08L83/04

    CPC classification number: G02B1/043 ,  C08G77/20 ,  C08G77/46 ,  C08L83/04 ,  C08L83/08 ,  C08L2201/10

    Abstract: A composition, suitable for use in producing hydrogel polymer films from which biomedical devices such as contact lenses can be made, comprising at least one hydrophilic silicone macromer. In one aspect, a hydrophilic silicone macromer is of the Formula 1: X—Si(R1)(R2)O—(Si(R3)(R4)O)a—Si(R5)(R6)—Y   (1) wherein R1, R2, R3 R4, R5 and R6 are independently selected from a monovalent linear, branched, or cyclic radical with 1 to 50 carbon atoms, that can optionally contain a heteroatom or I; I is RL-RP; Y is a free radical polymerization-effective hydrophilic group with the general structure:RL-RP—Z; RL is a linking residue from a non-isomerizable hydrosilylation effective terminal olefin comprising the general structure —CH2—C(RbR7)—(CR8R9)m, the subscript n is selected from integers from 1 to 10; R7, R8, and R9 can be selected from hydrogen and a mono-valent hydrocarbon radical with 1 to 10 carbon atoms that optionally contain a heteroatom; Rb is selected from a monovalent hydrocarbon radical with 1 to 6 carbon atoms; RP is a spacer group comprising a diavelant hydrophilic organic radical with 0 to 100 carbon atoms and optionally contains heteroatoms, and X is a free radical polymerizable group. The said composition can be polymers and films suitable for use in making contact lenses.

    Abstract translation: 一种适用于生产水凝胶聚合物膜的组合物，其中可以制备诸如隐形眼镜的生物医学装置，其包含至少一种亲水硅氧烷大分子单体。 一方面，亲水性硅氧烷大分子单体为式1：X-Si（R1）（R2）O-（Si（R3）（R4）O）a-Si（R5）（R6）-Y（1）其中 R 1，R 2，R 3，R 4，R 5和R 6独立地选自具有1至50个碳原子的一价直链，支链或环状基团，其可任选地含有杂原子或I; 我是RL-RP; Y是具有一般结构的自由基聚合有效的亲水基团：RL-RP-Z; RL是来自包含通式-CH 2 -C（RbR 7） - （CR 8 R 9）m的非异构化氢化硅烷化有效末端烯烃的连接残基，下标n选自1至10的整数; R 7，R 8和R 9可以选自氢和具有1-10个碳原子的任选含有杂原子的一价烃基; Rb选自具有1至6个碳原子的一价烃基; RP是包含具有0至100个碳原子的疏水性亲水性有机基团并且任选地含有杂原子的间隔基，X是可自由基聚合的基团。 所述组合物可以是适合用于制造隐形眼镜的聚合物和薄膜。

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