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15 条记录 (耗时 0.019 秒)

    Prostate cancer diagnosis and treatment
    7.
    发明授权
    Prostate cancer diagnosis and treatment 有权
    前列腺癌的诊断和治疗

    公开(公告)号：US07910693B2

    公开(公告)日：2011-03-22

    申请号：US11568089

    申请日：2005-04-19

    申请人： Claudio Cuello ,  Uri Saragovi ,  Pierre Du Ruisseau ,  Phil Gold ,  Serge Moffett

    发明人： Claudio Cuello ,  Uri Saragovi ,  Pierre Du Ruisseau ,  Phil Gold ,  Serge Moffett

    IPC分类号： A61K38/12

    CPC分类号： C07K16/3069 ,  C07K2317/34 ,  G01N33/57434 ,  G01N2333/705 ,  G01N2800/52

    摘要： The present invention relates to novel mimetopes of anti-PSMA antibodies and their use for detecting, imaging, staging, treating and monitoring of prostate cancer, and/or metastatis thereof. The present invention also relates to novel pharmaceutical compositions for the treatment of prostate cancer. Furthermore the present invention relates to assay systems and kits for detecting, imaging, staging, treating and monitoring of prostate cancer, and/or metastasis thereof.

    摘要翻译： 本发明涉及抗PSMA抗体的新型甲基化及其用于检测，成像，分期，治疗和监测前列腺癌和/或其转移的用途。 本发明还涉及用于治疗前列腺癌的新型药物组合物。 此外，本发明涉及用于检测，成像，分期，治疗和监测前列腺癌和/或其转移的测定系统和试剂盒。

    Antagonistic peptides of prostaglandin E2 receptor subtype EP4
    9.
    发明申请
    Antagonistic peptides of prostaglandin E2 receptor subtype EP4 失效
    前列腺素E2受体亚型EP4拮抗肽

    公开(公告)号：US20050164949A1

    公开(公告)日：2005-07-28

    申请号：US10968872

    申请日：2004-10-19

    申请人： Krishna Peri ,  Serge Moffett ,  Daniel Abran ,  Annie Bergeron

    发明人： Krishna Peri ,  Serge Moffett ,  Daniel Abran ,  Annie Bergeron

    IPC分类号： A61K38/00 ,  C07K7/06 ,  A61K38/08

    CPC分类号： C07K7/06 ,  A61K38/00 ,  C07B2200/05 ,  Y02P20/55

    摘要： Antagonistic peptides of prostaglandin E2 receptor subtype EP4 and their use in the treatment or prevention of medical conditions associated with oligouric nephropathy, bone resorption, abnormal intestinal crypt cell proliferation or patency of the ductus arteriosus and the like are provided herein. The antagonistic peptides of the present invention can include the following formula: X-ARnYm wherein “X” is a hydrogen atom or an amine protecting group producing a carbamate or an amide when reacting with the amine; “A” is L-(4,4′)-biphenylalanine or D-(4,4′)-biphenylalanine; “R” is an amino acid selected from the group consisting of threonine, serine, tyrosine, glutamic acid, alanine, leucine and glycine; “Y” is lysine; “n” is an integer ranging from 5 to 7; and “m” is an integer ranging from 0 to 2.

    摘要翻译： 前列腺素E2受体亚型EP4的拮抗肽及其在治疗或预防与寡尿性肾病相关的医学病症，骨吸收，动脉导管未闭的肠道隐窝细胞增殖或通畅等中的用途。 本发明的拮抗肽可以包括下列公式：<？in-line-formula description =“In-line Formulas”end =“lead”？>XAR > m <？in-line-formula description =“In-line Formulas”end =“tail”？>其中“X”是氢原子，或当产生氨基甲酸酯或酰胺的胺保护基与 胺; “A”是L-（4,4'） - 联苯基丙氨酸或D-（4,4'） - 联苯基丙氨酸; “R”是选自苏氨酸，丝氨酸，酪氨酸，谷氨酸，丙氨酸，亮氨酸和甘氨酸的氨基酸; “Y”是赖氨酸; “n”为5〜7的整数; “m”为0〜2的整数。

    Antagonistic peptides of prostaglandin E2 receptor subtype EP4
    10.
    发明授权
    Antagonistic peptides of prostaglandin E2 receptor subtype EP4 失效
    前列腺素E2受体亚型EP4拮抗肽

    公开(公告)号：US07414029B2

    公开(公告)日：2008-08-19

    申请号：US10968872

    申请日：2004-10-19

    申请人： Krishna G. Peri ,  Serge Moffett ,  Daniel Abran ,  Annie Bergeron

    发明人： Krishna G. Peri ,  Serge Moffett ,  Daniel Abran ,  Annie Bergeron

    IPC分类号： A61K38/08 ,  C07K7/06

    CPC分类号： C07K7/06 ,  A61K38/00 ,  C07B2200/05 ,  Y02P20/55

    摘要： Antagonistic peptides of prostaglandin E2 receptor subtype EP4 and their use in the treatment or prevention of medical conditions associated with oligouric nephropathy, bone resorption, abnormal intestinal crypt cell proliferation or patency of the ductus arteriosus and the like are provided herein. The antagonistic peptides of the present invention can include the following formula: X-A-RnYm wherein “X” is a hydrogen atom or an amine protecting group producing a carbamate or an amide when reacting with the amine; “A” is L-(4,4′)-biphenylalanine or D-(4,4′)-biphenylalanine; “R” is an amino acid selected from the group consisting of threonine, serine, tyrosine, glutamic acid, alanine, leucine and glycine; “Y” is lysine; “n” is an integer ranging from 5 to 7; and “m” is an integer ranging from 0 to 2.

    摘要翻译： 前列腺素E2受体亚型EP4的拮抗肽及其在治疗或预防与寡尿性肾病相关的医学病症，骨吸收，动脉导管未闭的肠道隐窝细胞增殖或通畅等中的用途。 本发明的拮抗肽可以包括以下公式：<？in-line-formula description =“In-line Formulas”end =“lead”？> XA- R Y “是当与胺反应时是氢原子或产生氨基甲酸酯或酰胺的胺保护基; “A”是L-（4,4'） - 联苯基丙氨酸或D-（4,4'） - 联苯基丙氨酸; “R”是选自苏氨酸，丝氨酸，酪氨酸，谷氨酸，丙氨酸，亮氨酸和甘氨酸的氨基酸; “Y”是赖氨酸; “n”为5〜7的整数; “m”为0〜2的整数。