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公开(公告)号：US20140341901A1
公开(公告)日：2014-11-20
申请号：US14163230
申请日：2014-01-24
申请人： Janine R. SHULOK , Feng CONG , Mark C. FISHMAN , Seth ETTENBERG , Michael BARDROFF , Mariel DONZEAU , Stefanie URLINGER
发明人： Janine R. SHULOK , Feng CONG , Mark C. FISHMAN , Seth ETTENBERG , Michael BARDROFF , Mariel DONZEAU , Stefanie URLINGER
IPC分类号： C07K16/22 , A61K45/06 , A61K31/675 , A61K39/395
CPC分类号： C07K16/22 , A61K31/675 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/92
摘要： Antibodies and fragments that bind to the protein target Dickkopf (DKK1) are provided, as are methods of use and kits, for treating a target cell, in particular, a cell associated with an osteolytic condition.
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公开(公告)号：US08673306B2
公开(公告)日：2014-03-18
申请号：US12160875
申请日：2007-01-12
申请人： Janine Shulok , Feng Cong , Mark Fishman , Seth Ettenberg , Michael Bardroff , Mariel Donzeau , Stefanie Urlinger
发明人： Janine Shulok , Feng Cong , Mark Fishman , Seth Ettenberg , Michael Bardroff , Mariel Donzeau , Stefanie Urlinger
IPC分类号： A61K39/395
CPC分类号： C07K16/22 , A61K31/675 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/92
摘要： Antibodies and fragments that bind to the protein target Dickkopf (DKK1) are provided, as are methods of use and kits, for treating a target cell, in particular, a cell associated with an osteolytic condition.
摘要翻译： 提供与蛋白质靶标Dickkopf（DKK1）结合的抗体和片段，以及用于治疗靶细胞，特别是与溶骨性病症相关的细胞的使用方法和试剂盒。
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3.发明申请COMPOSITIONS AND METHODS OF USE FOR THERAPEUTIC LOW DENSITY LIPOPROTEIN - RELATED PROTEIN 6 (LRP6) MULTIVALENT ANTIBODIES 有权用于治疗性低密度脂蛋白相关蛋白6（LRP6）多种抗体的组合物和方法公开(公告)号：US20130064823A1
公开(公告)日：2013-03-14
申请号：US13696372
申请日：2011-05-05
申请人： Feng Cong , Seth Ettenberg , David Jenkins , Ming Lei , Andreas Loew , Karen Vincent , Li Zhou
发明人： Feng Cong , Seth Ettenberg , David Jenkins , Ming Lei , Andreas Loew , Karen Vincent , Li Zhou
CPC分类号： C07K16/2863 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K16/28 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/35 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The present disclosure relates to an antibody or antigen binding fragment having at least two receptor binding do mains for two different binding sites of LRP6 and compositions and methods of use thereof.
摘要翻译： 本公开内容涉及具有至少两个受体结合的抗体或抗原结合片段，其用于LRP6的两个不同结合位点和组合物及其使用方法。
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公开(公告)号：US20070098715A1
公开(公告)日：2007-05-03
申请号：US11391630
申请日：2006-03-27
IPC分类号： A61K39/395 , G01N33/567 , C07K16/28
CPC分类号： C07K16/30 , A61K47/6825 , A61K47/6851 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/73 , C07K2317/77 , C07K2317/92
摘要： The invention described herein relates to antibodies directed to the antigen Ten-M2 and uses of such antibodies. In particular, there are provided fully human monoclonal antibodies directed to the antigen Ten-M2. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
摘要翻译： 本文描述的本发明涉及针对抗原Ten-M2的抗体和这种抗体的用途。 特别地，提供针对抗原Ten-M2的完全人单克隆抗体。 分离的多核苷酸序列编码和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区（FR）和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是FR1至FR4 或CDR1至CDR3。 还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。
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5.发明授权Compositions and methods of use for therapeutic low density lipoprotein-related protein 6 (LRP6) multivalent antibodies 有权用于治疗性低密度脂蛋白相关蛋白6（LRP6）多价抗体的组合物和方法公开(公告)号：US09428583B2
公开(公告)日：2016-08-30
申请号：US13696532
申请日：2011-05-05
申请人： Feng Cong , Seth Ettenberg , Felix Hartlepp , Ingo Klagge
发明人： Feng Cong , Seth Ettenberg , Felix Hartlepp , Ingo Klagge
CPC分类号： C07K16/2863 , A61K2039/505 , A61P35/00 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/35 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The present disclosure relates to antibodies targeting LRP6 and compositions and methods of use thereof.
摘要翻译： 本公开内容涉及靶向LRP6的抗体及其组合物及其使用方法。
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公开(公告)号：US20140170147A1
公开(公告)日：2014-06-19
申请号：US14178892
申请日：2014-02-12
申请人： Janine R. SHULOK , Feng CONG , Mark C. FISHMAN , Seth ETTENBERG , Michael BARDROFF , Mariel DONZEAU , Stefanie URLINGER
发明人： Janine R. SHULOK , Feng CONG , Mark C. FISHMAN , Seth ETTENBERG , Michael BARDROFF , Mariel DONZEAU , Stefanie URLINGER
IPC分类号： C07K16/22 , A61K31/675 , A61K39/395
CPC分类号： C07K16/22 , A61K31/675 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/92
摘要： Antibodies and fragments that bind to the protein target Dickkopf (DKK1) are provided, as are methods of use and kits, for treating a target cell, in particular, a cell associated with an osteolytic condition.
摘要翻译： 提供了与蛋白质靶标Dickkopf（DKK1）结合的抗体和片段，以及用于治疗靶细胞，特别是与溶骨性病症相关的细胞的使用方法和试剂盒。
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7.发明申请COMPOSITIONS AND METHODS OF USE FOR THERAPEUTIC LOW DENSITY LIPOPROTEIN - RELATED PROTEIN 6 (LRP6) MULTIVALENT ANTIBODIES 有权用于治疗性低密度脂蛋白相关蛋白6（LRP6）多种抗体的组合物和方法公开(公告)号：US20130058934A1
公开(公告)日：2013-03-07
申请号：US13696532
申请日：2011-05-05
申请人： Feng Cong , Seth Ettenberg , Felix Hartlepp , Ingo Klagge
发明人： Feng Cong , Seth Ettenberg , Felix Hartlepp , Ingo Klagge
CPC分类号： C07K16/2863 , A61K2039/505 , A61P35/00 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/35 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The present disclosure relates to antibodies targeting LRP6 and compositions and methods of use thereof.
摘要翻译： 本公开内容涉及靶向LRP6的抗体及其组合物及其使用方法。
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公开(公告)号：US20110318366A1
公开(公告)日：2011-12-29
申请号：US13024174
申请日：2011-02-09
申请人： Karen CROMIE , Bruno DOMBRECHT , Seth ETTENBERG , Joost KOLKMAN , Jing LI , Kris MEERSCHAERT , David Raymond STOVER , Jingxin ZHANG
发明人： Karen CROMIE , Bruno DOMBRECHT , Seth ETTENBERG , Joost KOLKMAN , Jing LI , Kris MEERSCHAERT , David Raymond STOVER , Jingxin ZHANG
IPC分类号： A61K39/395 , A61P35/00 , A61P35/02 , C07K16/28
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2316/95 , C07K2317/22 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/75 , C07K2317/76
摘要： The present invention relates to amino acid sequences that are directed against TRAIL cell surface receptor 2 (herein also “DR5”), as well as to compounds or constructs thereof, and in particular proteins and polypeptides and nucleotides that encode them (referred to herein in their entirety as “NB agents”) and fragments thereof, and pharmaceutically effective variants thereof, and their use in the diagnosis and treatment of DR5 associated diseases and disorders.
摘要翻译： 本发明涉及针对TRAIL细胞表面受体2（本文还称为“DR5”）的氨基酸序列以及编码它们的化合物或构建体，特别是编码它们的蛋白质和多肽和核苷酸（在本文中称为 其整体作为“NB剂”）及其片段及其药学上有效的变体，以及它们在诊断和治疗DR5相关疾病和病症中的用途。
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9.发明授权Therapeutic low density lipoprotein-related protein 6 (LRP6) multivalent antibodies 有权治疗性低密度脂蛋白相关蛋白6（LRP6）多价抗体公开(公告)号：US09290573B2
公开(公告)日：2016-03-22
申请号：US13696372
申请日：2011-05-05
申请人： Feng Cong , Seth Ettenberg , David Jenkins , Ming Lei , Andreas Loew , Karen Vincent , Li Zhou
发明人： Feng Cong , Seth Ettenberg , David Jenkins , Ming Lei , Andreas Loew , Karen Vincent , Li Zhou
IPC分类号： C07K16/28 , C07K16/46 , A61K39/395 , A61K39/00
CPC分类号： C07K16/2863 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K16/28 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/35 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The present disclosure relates to an antibody or antigen binding fragment having at least two receptor binding domains for two different binding sites of LRP6 and compositions and methods of use thereof.
摘要翻译： 本公开涉及具有至少两个LRP6的两个不同结合位点的受体结合结构域的抗体或抗原结合片段及其组合物及其使用方法。
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公开(公告)号：US20120023600A1
公开(公告)日：2012-01-26
申请号：US12160875
申请日：2007-01-12
申请人： Janine Shulok , Feng Cong , Mark Fishman , Seth Ettenberg , Michael Bardroff , Mariel Donzeau , Stefanie Urlinger
发明人： Janine Shulok , Feng Cong , Mark Fishman , Seth Ettenberg , Michael Bardroff , Mariel Donzeau , Stefanie Urlinger
IPC分类号： C07K16/18 , A01K67/027 , A61P35/00 , A61P17/14 , A61P3/04 , A61P21/00 , A61P25/28 , A61P29/00 , A61K39/395 , A61P3/10
CPC分类号： C07K16/22 , A61K31/675 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/92
摘要： Antibodies and fragments that bind to the protein target Dickkopf (DKK1) are provided, as are methods of use and kits, for treating a target cell, in particular, a cell associated with an osteolytic condition.
摘要翻译： 提供与蛋白质靶标Dickkopf（DKK1）结合的抗体和片段，以及用于治疗靶细胞，特别是与溶骨性病症相关的细胞的使用方法和试剂盒。
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