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    Novel proteins and nucleic acids encoding same
    1.
    发明申请
    Novel proteins and nucleic acids encoding same 审中-公开

    公开(公告)号：US20060211031A1

    公开(公告)日：2006-09-21

    申请号：US11398823

    申请日：2006-04-06

    Applicant: Haihong Zhong ,  William LaRochelle ,  Suresh Shenoy ,  Nikolai Khramtsov

    Inventor： Haihong Zhong ,  William LaRochelle ,  Suresh Shenoy ,  Nikolai Khramtsov

    IPC: C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82 ,  C07K16/30

    CPC classification number: C07K14/705 ,  A61K38/00 ,  C07K14/47

    Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

    Antibodies Directed to Angiopoietin-like Protein 4 and Uses Thereof
    2.
    发明申请
    Antibodies Directed to Angiopoietin-like Protein 4 and Uses Thereof 审中-公开
    针对促血管生成素蛋白4的抗体及其用途

    公开(公告)号：US20140302055A1

    公开(公告)日：2014-10-09

    申请号：US13651665

    申请日：2012-10-15

    Applicant: Haihong Zhong ,  Qing Zhou

    Inventor： Haihong Zhong ,  Qing Zhou

    IPC: C07K16/22 ,  A61K51/10 ,  G01N33/574 ,  A61K47/48

    CPC classification number: C07K16/22 ,  A61K39/39533 ,  A61K47/6845 ,  A61K51/1021 ,  A61K2039/505 ,  A61P9/10 ,  A61P19/02 ,  A61P35/00 ,  C07K14/515 ,  C07K16/18 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/57488

    Abstract: Antibodies directed to the antigen ANGPTL4 and uses of such antibodies. In accordance with the teachings herein, there are provided fully human monoclonal antibodies directed to the antigen ANGPTL4. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

    Abstract translation: 针对抗原ANGPTL4的抗体和这种抗体的用途。 根据本文的教导，提供针对抗原ANGPTL4的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 ，提供。 也提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

    Antibodies against the tenascin major antigens
    3.
    发明申请
    Antibodies against the tenascin major antigens 审中-公开
    抗腱生蛋白主要抗原的抗体

    公开(公告)号：US20070098715A1

    公开(公告)日：2007-05-03

    申请号：US11391630

    申请日：2006-03-27

    Applicant: Seth Ettenberg ,  Stephanie Masterman ,  William LaRochelle ,  Haihong Zhong

    Inventor： Seth Ettenberg ,  Stephanie Masterman ,  William LaRochelle ,  Haihong Zhong

    IPC: A61K39/395 ,  G01N33/567 ,  C07K16/28

    CPC classification number: C07K16/30 ,  A61K47/6825 ,  A61K47/6851 ,  A61K2039/505 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/73 ,  C07K2317/77 ,  C07K2317/92

    Abstract: The invention described herein relates to antibodies directed to the antigen Ten-M2 and uses of such antibodies. In particular, there are provided fully human monoclonal antibodies directed to the antigen Ten-M2. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

    Abstract translation: 本文描述的本发明涉及针对抗原Ten-M2的抗体和这种抗体的用途。 特别地，提供针对抗原Ten-M2的完全人单克隆抗体。 分离的多核苷酸序列编码和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区（FR）和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是FR1至FR4 或CDR1至CDR3。 还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

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