公开(公告)号：US06683095B2

公开(公告)日：2004-01-27

申请号：US10275066

申请日：2002-11-01

申请人： Chang-Yong Hong ,  Jin-Ho Lee ,  Tae-Sik Park ,  Jong-Hyun Kim ,  Sei-Hyun Choi ,  Sook-Kyung Yoon ,  Hyun-Ho Chung ,  Ho-Sun Son ,  Eunice Eun-Kyeong Kim ,  Seong-Gu Ro ,  Shin-Wu Jeong ,  Dong-Myung Kim

发明人： Chang-Yong Hong ,  Jin-Ho Lee ,  Tae-Sik Park ,  Jong-Hyun Kim ,  Sei-Hyun Choi ,  Sook-Kyung Yoon ,  Hyun-Ho Chung ,  Ho-Sun Son ,  Eunice Eun-Kyeong Kim ,  Seong-Gu Ro ,  Shin-Wu Jeong ,  Dong-Myung Kim

IPC分类号： A61K31453

CPC分类号： C07D405/04 ,  C07D311/30 ,  C07D417/04 ,  C07D417/14

摘要： A novel 3-hydroxychromen-4-one derivative, pharmaceutically acceptable salt, hydrate, solvate or isomer thereof which is useful as an inhibitor for Cyclin Dependent Kinase (“CDK”) is disclosed. Further, a process for preparing the compound and a composition for suppression or treatment of cancer and diseases induced by cell proliferation such as inflammation, angiostenosis, angiogenesis, etc. is disclosed comprising the compound as an active component together with pharmaceutically acceptable carriers.

摘要翻译： 公开了一种可用作细胞周期蛋白依赖性激酶（“CDK”）抑制剂的新型3-羟基色烯-4-酮衍生物，其药学上可接受的盐，水合物，溶剂合物或异构体。 此外，公开了一种制备化合物的方法和用于抑制或治疗癌症的组合物以及由细胞增殖如炎症，血管狭窄症，血管发生等引起的疾病，其包括作为活性成分的化合物以及药学上可接受的载体。

公开(公告)号：US06268363B1

公开(公告)日：2001-07-31

申请号：US09554646

申请日：2000-05-17

申请人： Hyun Il Lee ,  Jong Sung Koh ,  Jin Ho Lee ,  Won Hee Jung ,  You Seung Shin ,  Hyun Ho Chung ,  Jong Hyun Kim ,  Seong Gu Ro ,  Tae Saeng Choi ,  Shin Wu Jeong ,  Tae Hwan Kwak ,  In Ae Ahn ,  Hyun Sung Kim ,  Sun Hwa Lee ,  Kwi Hwa Kim ,  Jung Kwon Yoo

发明人： Hyun Il Lee ,  Jong Sung Koh ,  Jin Ho Lee ,  Won Hee Jung ,  You Seung Shin ,  Hyun Ho Chung ,  Jong Hyun Kim ,  Seong Gu Ro ,  Tae Saeng Choi ,  Shin Wu Jeong ,  Tae Hwan Kwak ,  In Ae Ahn ,  Hyun Sung Kim ,  Sun Hwa Lee ,  Kwi Hwa Kim ,  Jung Kwon Yoo

IPC分类号： A61K314178

CPC分类号： C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D413/06 ,  C07D417/06 ,  C07D417/14

摘要： The present invention relates to a novel imidazole derivative represented by formula (1) which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof, in which A, n1 and Y are defined in the specification; to a process for preparation of the compound of formula (1); to intermediates which are used in the preparation of the compound of formula (1); and to a pharmaceutical composition comprising the compound of formula (1) as an active ingredient.

摘要翻译： 本发明涉及式（1）所示的新型咪唑衍生物，其表现出对法呢基转移酶的抑制活性或其药学上可接受的盐或异构体，其中A，n1和Y在本说明书中定义; 涉及制备式（1）化合物的方法; 用于制备式（1）化合物的中间体; 以及包含式（1）化合物作为活性成分的药物组合物。

公开(公告)号：US06518429B2

公开(公告)日：2003-02-11

申请号：US09813437

申请日：2001-03-20

申请人： Hyun Il Lee ,  Jong Sung Koh ,  Jin Ho Lee ,  Won Hee Jung ,  You Seung Shin ,  Hyun Ho Chung ,  Jong Hyun Kim ,  Seong Gu Ro ,  Tae Saeng Choi ,  Shin Wu Jeong ,  Tae Hwan Kwak ,  In Ae Ahn ,  Hyun Sung Kim ,  Sun Hwa Lee ,  Kwi Hwa Kim ,  Jung Kwon Yoo

发明人： Hyun Il Lee ,  Jong Sung Koh ,  Jin Ho Lee ,  Won Hee Jung ,  You Seung Shin ,  Hyun Ho Chung ,  Jong Hyun Kim ,  Seong Gu Ro ,  Tae Saeng Choi ,  Shin Wu Jeong ,  Tae Hwan Kwak ,  In Ae Ahn ,  Hyun Sung Kim ,  Sun Hwa Lee ,  Kwi Hwa Kim ,  Jung Kwon Yoo

IPC分类号： C07D45302

CPC分类号： C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D413/06 ,  C07D417/06 ,  C07D417/14

摘要： The present invention relates to novel imidazole derivatives which show an inhibitory activity against farnesyl transferase, pharmaceutically acceptable salts or isomers thereof and pharmaceutical compositions comprising such imidazole derivatives. More particularly, the present invention relates to intermediate compounds which are used in the preparation of the imidazole derivatives of the invention. Related processes also are disclosed.

公开(公告)号：US06511978B1

公开(公告)日：2003-01-28

申请号：US09958478

申请日：2001-10-11

申请人： Jong-Sung Koh ,  Hyun-Il Lee ,  You-Seung Shin ,  Hak-Joong Kim ,  Jin-Ho Lee ,  Jong-Hyun Kim ,  Hyun-Ho Chung ,  Shin-Wu Jeong ,  Tae-Saeng Choi ,  Jung-Kwon Yoo ,  Chung-Mi Kim ,  Kwi-Hwa Kim ,  Sun-Hwa Lee ,  Sang-Kyun Lee

发明人： Jong-Sung Koh ,  Hyun-Il Lee ,  You-Seung Shin ,  Hak-Joong Kim ,  Jin-Ho Lee ,  Jong-Hyun Kim ,  Hyun-Ho Chung ,  Shin-Wu Jeong ,  Tae-Saeng Choi ,  Jung-Kwon Yoo ,  Chung-Mi Kim ,  Kwi-Hwa Kim ,  Sun-Hwa Lee ,  Sang-Kyun Lee

IPC分类号： C07D40306

CPC分类号： C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D409/14

摘要： The present invention relates to a novel pyrrole derivative which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof; to a process for preparation of said compound; and to a pharmaceutical composition such as anti-cancer composition, etc. comprising said compound as an active ingredient together with pharmaceutically acceptable carrier.

摘要翻译： 本发明涉及对法呢基转移酶或其药学上可接受的盐或异构体具有抑制活性的新型吡咯衍生物; 涉及制备所述化合物的方法; 以及包含所述化合物作为活性成分以及药学上可接受的载体的药物组合物，例如抗癌组合物等。

公开(公告)号：US06472526B1

公开(公告)日：2002-10-29

申请号：US10005262

申请日：2001-12-03

申请人： Hyun Il Lee ,  Jong Sung Koh ,  Jin Ho Lee ,  Won Hee Jung ,  You Seung Shin ,  Hyun Ho Chung ,  Jong Hyun Kim ,  Seong Gu Ro ,  Tae Saeng Choi ,  Shin Wu Jeong ,  Tae Hwan Kwak ,  In Ae Ahn ,  Hyun Sung Kim ,  Sun Hwa Lee ,  Kwi Hwa Kim ,  Jung Kwon Yoo

发明人： Hyun Il Lee ,  Jong Sung Koh ,  Jin Ho Lee ,  Won Hee Jung ,  You Seung Shin ,  Hyun Ho Chung ,  Jong Hyun Kim ,  Seong Gu Ro ,  Tae Saeng Choi ,  Shin Wu Jeong ,  Tae Hwan Kwak ,  In Ae Ahn ,  Hyun Sung Kim ,  Sun Hwa Lee ,  Kwi Hwa Kim ,  Jung Kwon Yoo

IPC分类号： C07D40306

CPC分类号： C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D413/06 ,  C07D417/06 ,  C07D417/14

摘要： The present invention relates to a novel imidazole derivative represented by formula (1) which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof, in which A, n1 and Y are defined in the specification; to a process for preparation of the compound of formula (1); to intermediates which are used in the preparation of the compound of formula (1): and to a pharmaceutical composition comprising the compound of formula (1) as an active ingredient.

摘要翻译： 本发明涉及式（1）所示的新型咪唑衍生物，其表现出对法呢基转移酶的抑制活性或其药学上可接受的盐或异构体，其中A，n1和Y在本说明书中定义; 涉及制备式（1）化合物的方法; 用于制备式（1）化合物的中间体：和包含式（1）化合物作为活性成分的药物组合物。

公开(公告)号：US06620831B2

公开(公告)日：2003-09-16

申请号：US10275176

申请日：2002-11-04

申请人： Jin-Ho Lee ,  Chang-Yong Hong ,  Tae-Sik Park ,  Jong-Hyun Kim ,  Sei-Hyun Choi ,  Sook-Kyung Yoon ,  Hyun-Ho Chung ,  Shin-Wu Jeong ,  Kwang-Yeon Hwang ,  Dong-Kyu Shin

发明人： Jin-Ho Lee ,  Chang-Yong Hong ,  Tae-Sik Park ,  Jong-Hyun Kim ,  Sei-Hyun Choi ,  Sook-Kyung Yoon ,  Hyun-Ho Chung ,  Shin-Wu Jeong ,  Kwang-Yeon Hwang ,  Dong-Kyu Shin

IPC分类号： C07D41714

CPC分类号： C07D417/04 ,  C07D417/14

摘要： The present invention relates to an indazole derivative, pharmaceutically acceptable salt, solvated product and isomer thereof substituted with 1,1-dioxoisothiazolidine which are useful as inhibitors for Cyclin Dependent Kinase(CDK). The present invention also relates to an agent for inhibiting and treating diseases involving cell proliferation, e.g., cancer, inflammation, restenosis, angiogenesis, etc. which comprises the compound of formula (1) as an active ingredient together with a pharmaceutically acceptable carrier.

摘要翻译： 本发明涉及可用作细胞周期蛋白依赖性激酶（CDK）抑制剂的1,1-二氧代异噻唑烷取代的吲唑衍生物，药用盐，溶剂合物及其异构体。 本发明还涉及包含式（1）化合物作为活性成分的药物可接受的载体的抑制和治疗涉及细胞增殖的疾病，例如癌症，炎症，再狭窄，血管发生等的药剂。