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    CATIONIC ANTIMICROBIAL OLIGO-GUANIDINIUM DENDRIMERS AND COMPOSITIONS
    1.
    发明申请
    CATIONIC ANTIMICROBIAL OLIGO-GUANIDINIUM DENDRIMERS AND COMPOSITIONS 有权

    公开(公告)号：US20220362176A1

    公开(公告)日：2022-11-17

    申请号：US17744470

    申请日：2022-05-13

    申请人： Hyun Ho Chung

    发明人： Hyun Ho Chung

    IPC分类号： A61K31/155 ,  C07C277/08 ,  A61P31/04 ,  A01N47/44 ,  A01P1/00 ,  A61K47/55

    摘要： A new synthesized non-peptide cationic oligo-guanidinium dendrimers containing a number of positive charges, 6, 9, 12, and 18 for use as antimicrobial agents and a method for synthesizing non-peptide cationic oligo-guanidinium dendrimers G12 and G18. These designed and synthesized dendrimers exhibit antimicrobial activities as well as biofilm disrupting activity against various pathogens such as Gram-negative bacteria, Gram-positive bacteria, and fungi. The application of these dendrimers are very broad, which includes application to pharmaceutical compounds that are covalently or non-covalently complexed. These combinations are important in helping the body reach the proper immune balance required for maximized function and/or optimal health.

    NUTRITIONAL FORMULATION FOR CANCER PREVENTION
    5.
    发明申请
    NUTRITIONAL FORMULATION FOR CANCER PREVENTION 有权

    公开(公告)号：US20220257640A1

    公开(公告)日：2022-08-18

    申请号：US17669581

    申请日：2022-02-11

    申请人： Hyun Ho Chung

    发明人： Hyun Ho Chung

    IPC分类号： A61K31/737 ,  A61K31/047 ,  A61K31/01 ,  A61K31/12 ,  A61K31/198 ,  A61K31/122 ,  A61K31/375 ,  A61K36/07 ,  A61K36/185 ,  A61K36/9066

    摘要： A nutritional supplement containing specific natural ingredients and composition to target cancer vulnerability. The supplement includes between 100 to 300 mg Fucoidan, between 5 and 20 mg Lutein, between 5 and 20 mg Lycopene, between 100 and 300 mg Curcumin, between 5 and 20 mg Astaxantin, between 10 and 100 mg of Siberian Chaga extract powder and between 50 and 200 mg Vitamin C, natural vitamin C from Acerola Cherry, Astaxanthin extract (96%), Curcumin (95%), Lycopene extract (96%), Lutein extract (80%), Siberian Chaga extract, and Fucoidan extract from a brown algae, Undaria pinnatifida. The administration of combinations of these nutrients in set ratio increase anti-cancer activities and the body's ability to prevent cancer. These combinations are also important in helping the body reach the proper immune balance required for maximized function and/or optimal health. All amounts by weight.

    Dendrimers as Molecular Translocators
    6.
    发明申请
    Dendrimers as Molecular Translocators 审中-公开
    树枝状大分子作为分子转运子

    公开(公告)号：US20080221020A1

    公开(公告)日：2008-09-11

    申请号：US10522130

    申请日：2003-07-18

    申请人： Murray Goodman ,  Churl Min Seong ,  Guido Harms ,  Changhee Min ,  Byung Hyune Choi ,  Hyun-Ho Chung

    发明人： Murray Goodman ,  Churl Min Seong ,  Guido Harms ,  Changhee Min ,  Byung Hyune Choi ,  Hyun-Ho Chung

    IPC分类号： A61K38/17 ,  C07D473/38 ,  C07D213/71 ,  C07K19/00

    CPC分类号： C08G73/024 ,  A61K47/59 ,  A61K47/595 ,  A61K47/6949 ,  B82Y5/00 ,  C08G83/003

    摘要： Transport molecules include a dendrimer and a biologically active molecule. The dendrimer of such transport molecules includes at least one guanidine group, at least one protonated guanidine group, at least one protected guanidine group, at least one amidine group, at least one protonated amidine group, at least one protected amidine group, at least one ureido group, at least one protonated ureido group, at least one protected ureido group, at least one thioureido group, at least one protonated thioureido group, or at least one protected thioureido group. The biologically active molecule is bonded to the dendrimer. A method of increasing the bioavailability of a drug includes bonding the drug to a dendrimer of the invention.

    摘要翻译： 运输分子包括树枝状大分子和生物活性分子。 该转运分子的树枝状大分子包括至少一个胍基，至少一个质子化胍基，至少一个被保护的胍基，至少一个脒基，至少一个质子化的脒基，至少一个保护的脒基，至少一个 脲基，至少一个质子化脲基，至少一个保护的脲基，至少一个硫脲基，至少一个质子化硫脲基或至少一个被保护的硫脲基。 生物活性分子与树枝状大分子结合。 提高药物的生物利用度的方法包括将药物结合到本发明的树枝状大分子。