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13 条记录 (耗时 0.012 秒)

    Prostacyclins and process for production thereof
    1.
    发明授权
    Prostacyclins and process for production thereof 失效
    前列环素及其制备方法

    公开(公告)号：US4736058A

    公开(公告)日：1988-04-05

    申请号：US662415

    申请日：1984-09-27

    申请人： Shiro Ikegami ,  Seizi Kurozumi

    发明人： Shiro Ikegami ,  Seizi Kurozumi

    IPC分类号： C07C67/30 ,  A61K31/557 ,  A61P7/02 ,  A61P43/00 ,  C07C51/00 ,  C07C59/46 ,  C07C67/00 ,  C07C69/73 ,  C07C69/732 ,  C07C231/00 ,  C07C231/12 ,  C07C235/30 ,  C07C405/00 ,  C07D309/12 ,  C07F7/18 ,  C07C177/00

    CPC分类号： C07C405/0083 ,  Y02P20/55

    摘要： A novel prostacyclins expressed by the following formula (1) ##STR1## wherein a symbol between the 2-position and 3-position indicates single bond or double bond; G indicates --CO.sub.2 R.sup.5 or --CONR.sup.6 R.sup.7 in which R.sup.5 is a hydrogen atom, C.sub.1 -C.sub.10 alkyl group, substituted or unsubstituted alicyclic group, substituted or unsubstituted phenyl (C.sub.1 -C.sub.2) alkyl group, tri (C.sub.1 -C.sub.7) hydrocarbon-silyl group, or one equivalent cation, R.sup.6 and R.sup.7 are identical or different and each representing a hydrogen atom, or C.sub.1 -C.sub.10 alkyl group, or R.sup.6 and R.sup.7 are substituted or unsubstituted five to six-membered ring which may join together with a nitrogen atom to which they are linked and further contain a hetero atom; R.sup.1 indicates a hydrogen atom, or methyl group; R.sup.2 indicates an unsubstituted C.sub.3 -C.sub.8 alkyl group substituted or unsubstituted alicyclic group, or substituted C.sub.1 -C.sub.5 alkyl group substituted by substituents selected from phenyl, phenoxy, C.sub.1 -C.sub.6 alkoxy and C.sub.5 -C.sub.6 cycloalkyl group, which substituents may be substituted; and R.sup.3 and R.sup.4 are identical or different, each indicating a hydrogen atom, C.sub.2 -C.sub.7 acyl group, tri (C.sub.1 -C.sub.7) hydrocarbon-silyl group, or a group which forms an acetal linkage together with the oxygen atom of the hydroxyl group.The prostacyclins has an excellent pharmacological activity such as platelet aggregation inhibiting action, and is extremely useful for medicine such as antithrombotic drug and antiarteriosclerotic drug.

    摘要翻译： PCT No.PCT / JP84 / 00018 Sec。 371日期1984年9月27日 102（e）日期1984年9月27日PCT提交1984年1月26日PCT公布。 公开号WO84 / 02902 日本1984年8月2日。由下式（1）表示的新型前列环素，其中2位和3位之间的符号表示单键或双键; G表示-CO 2 R 5或-CONR 6 R 7，其中R 5是氢原子，C 1 -C 10烷基，取代或未取代的脂环基，取代或未取代的苯基（C 1 -C 2）烷基，三（C 1 -C 7）烃 - 甲硅烷基， 或一个等同的阳离子，R6和R7相同或不同，各自表示氢原子或C1-C10烷基，或R6和R7是取代或未取代的五至六元环，其可与氮原子连接在一起， 它们连接并进一步含有杂原子; R1表示氢原子或甲基; R2表示未取代的C3-C8烷基取代或未取代的脂环族基团或被选自苯基，苯氧基，C1-C6烷氧基和C5-C6环烷基的取代基取代的取代的C1-C5烷基，该取代基可以被取代; R3和R4相同或不同，分别表示氢原子，C2-C7酰基，三（C1-C7）烃 - 甲硅烷基，或与羟基的氧原子一起形成缩醛键的基团。 前列环素具有优异的药理活性，如血小板聚集抑制作用，对抗血栓药和抗动脉硬化药物等药物极为有用。

    Tetracalcium phosphate-based materials and processes for their preparation
    5.
    发明授权
    Tetracalcium phosphate-based materials and processes for their preparation 失效
    基于磷酸四钙的材料及其制备方法

    公开(公告)号：US5536575A

    公开(公告)日：1996-07-16

    申请号：US360330

    申请日：1994-12-21

    申请人： Akitoshi Imura ,  Toru Saito ,  Shiro Ikegami

    发明人： Akitoshi Imura ,  Toru Saito ,  Shiro Ikegami

    IPC分类号： A61F2/00 ,  A61K6/033 ,  A61L27/12 ,  A61L27/32 ,  C01B25/32 ,  B32B5/16

    CPC分类号： A61L27/12 ,  A61K6/0008 ,  A61K6/033 ,  A61K6/0643 ,  A61K6/0668 ,  A61K6/0675 ,  A61L27/32 ,  C01B25/327 ,  A61F2310/00293 ,  A61F2310/00796 ,  Y10T428/2991

    摘要： The invention provides (i) a process for preparing tetracalcium phosphate particles, the process comprising the steps of (1) sintering or fusing a powder mixture at a temperature of not lower than 1,400.degree. C., the mixture comprising a powder of calcium source and a powder of phosphorus source in a Ca/P molar ratio of 2/1, and about 0.005 to about 5 parts of an aluminum compound, calculated as Al.sub.2 O.sub.3, per 100 parts of tetracalcium phosphate to be produced in terms of the theoretical amount, and (2) finely dividing the obtained product; (ii) tetracalcium phosphate particles prepared by said process; (iii) apatite-coated tetracalcium phosphate particles; (iv) a process for preparing the apatite-coated tetracalcium phosphate particles; (v) a tetracalcium phosphate-based setting composition; (vi) a composition for forming a hardening material using coated tetracalcium phosphate particles and an acidic aqueous solution; and (vii) the composition as defined in (vi) in which the acidic aqueous solution can satisfy the concentration relationships as represented below:(a) 25%.ltoreq.citric acid.ltoreq.50%(b) 30%.ltoreq.citric acid+phosphoric acid.ltoreq.70%(c) 10%.ltoreq.citric acid-phosphoric acid.ltoreq.50%

    摘要翻译： 本发明提供（i）一种制备磷酸四钙颗粒的方法，所述方法包括以下步骤：（1）在不低于1400℃的温度下烧结或熔融粉末混合物，所述混合物包含钙源粉末和 按照理论量计算每100份磷酸四钙的磷源粉末，Ca / P摩尔比为2/1，约0.005至约5份按Al2O3计算的铝化合物，以及 （2）细分所得产物; （ii）通过所述方法制备的四磷酸钙颗粒; （iii）磷灰石涂覆的磷酸四钙颗粒; （iv）制备磷灰石涂覆的磷酸四钙颗粒的方法; （v）基于磷酸四钙的凝固组合物; （vi）使用包覆的磷酸四钙颗粒和酸性水溶液形成硬化材料的组合物; 和（vii）如（vi）中所定义的组成，其中酸性水溶液可以满足如下所示的浓度关系：（a）25％柠檬酸

    Tetracalcium phosphate-based materials and processes for their preparation
    8.
    发明授权
    Tetracalcium phosphate-based materials and processes for their preparation 失效

    公开(公告)号：US5569490A

    公开(公告)日：1996-10-29

    申请号：US458713

    申请日：1995-06-02

    申请人： Akitoshi Imura ,  Toru Saito ,  Shiro Ikegami

    发明人： Akitoshi Imura ,  Toru Saito ,  Shiro Ikegami

    IPC分类号： A61F2/00 ,  A61K6/033 ,  A61L27/12 ,  A61L27/32 ,  C01B25/32 ,  B05D7/00

    CPC分类号： A61L27/12 ,  A61K6/0008 ,  A61K6/033 ,  A61K6/0643 ,  A61K6/0668 ,  A61K6/0675 ,  A61L27/32 ,  C01B25/327 ,  A61F2310/00293 ,  A61F2310/00796 ,  Y10T428/2991

    摘要： The invention provides (i) a process for preparing tetracalcium phosphate particles, the process comprising the steps of (1) sintering or fusing a powder mixture at a temperature of not lower than 1,400.degree. C., the mixture comprising a powder of calcium source and a powder of phosphorus source in a Ca/P molar ratio of 2/1, and about 0.005 to about 5 parts of an aluminum compound, calculated as Al.sub.2 O.sub.3, per 100 parts of tetracalcium phosphate to be produced in terms of the theoretical amount, and (2) finely dividing the obtained product; (ii) tetracalcium phosphate particles prepared by said process; (iii) apatite-coated tetracalcium phosphate particles; (iv) a process for preparing the apatite-coated tetracalcium phosphate particles; (v) a tetracalcium phosphate-based setting composition; (vi) a composition for forming a hardening material using coated tetracalcium phosphate particles and an acidic aqueous solution; and (vii) the composition as defined in (vi) in which the acidic aqueous solution can satisfy the concentration relationships as represented below:(a) 25%.ltoreq.citric acid.ltoreq.50%(b) 30%.ltoreq.citric acid+phosphoric acid.ltoreq.70%(c) 10%.ltoreq.citric acid-phosphoric acid.ltoreq.50%