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公开(公告)号：US20070203061A1
公开(公告)日：2007-08-30
申请号：US10594969
申请日：2005-03-31
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , G01N33/6875 , G01N33/74 , G01N33/92 , G01N2500/10 , G01N2800/044
摘要： The present invention provides adiponectin expression-inducing agents, and therapeutic agents using the same for obesity and obesity-related diseases such as cardiovascular diseases or metabolic diseases, as well as methods of searching for adiponectin expression-inducing agents. KLF9, which can bind to the 32-bp fragment of position −188 to position −157 from the adiponectin expression start site, was demonstrated to enhance adiponectin promoter activity. Therefore, the present invention uses KLF9 as an adiponectin expression-inducing agent, and suggests that KLF9 replenishment therapy is useful for preventing and/or treating obesity or obesity-related diseases including metabolic diseases such as insulin resistance and type II diabetes, and cardiovascular diseases.
摘要翻译： 本发明提供了脂联素表达诱导剂和使用其的治疗剂用于肥胖症和肥胖相关疾病如心血管疾病或代谢疾病，以及搜索脂联素表达诱导剂的方法。 KLF9可以结合位点-188的32-bp片段，从脂联素表达起始位点到位置-157，证明增强脂连蛋白启动子活性。 因此，本发明使用KLF9作为脂联素表达诱导剂，并且表明KLF9补充疗法可用于预防和/或治疗肥胖症或肥胖相关疾病，包括诸如胰岛素抵抗和II型糖尿病等代谢疾病和心血管疾病 。
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公开(公告)号：US07741080B2
公开(公告)日：2010-06-22
申请号：US10594969
申请日：2005-03-31
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , G01N33/6875 , G01N33/74 , G01N33/92 , G01N2500/10 , G01N2800/044
摘要： The present invention provides adiponectin expression-inducing agents, and therapeutic agents using the same for obesity and obesity-related diseases such as cardiovascular diseases or metabolic diseases, as well as methods of searching for adiponectin expression-inducing agents.KLF9, which can bind to the 32-bp fragment of position −188 to position −157 from the adiponectin expression start site, was demonstrated to enhance adiponectin promoter activity. Therefore, the present invention uses KLF9 as an adiponectin expression-inducing agent, and suggests that KLF9 replenishment therapy is useful for preventing and/or treating obesity or obesity-related diseases including metabolic diseases such as insulin resistance and type II diabetes, and cardiovascular diseases.
摘要翻译： 本发明提供了脂联素表达诱导剂和使用其的治疗剂用于肥胖症和肥胖相关疾病如心血管疾病或代谢疾病，以及搜索脂联素表达诱导剂的方法。 KLF9可以结合位点-188的32-bp片段，从脂联素表达起始位点到位置-157，证明增强脂连蛋白启动子活性。 因此，本发明使用KLF9作为脂联素表达诱导剂，并且表明KLF9补充疗法可用于预防和/或治疗肥胖症或肥胖相关疾病，包括诸如胰岛素抵抗和II型糖尿病等代谢疾病和心血管疾病 。
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公开(公告)号：US6148110A
公开(公告)日：2000-11-14
申请号：US17945
申请日：1998-02-03
IPC分类号： H04N19/60 , G06T9/00 , H04N1/417 , H04N19/423 , H04N19/50 , H04N19/503 , H04N19/61 , H04N19/635 , H04N19/80 , H04N19/86 , H04N19/91 , G06K9/36
CPC分类号： G06T9/007
摘要： An image data processing apparatus includes a zero-value prediction compressor for compressing data by predicting a zero-value region of a high-layer from a low layer of a wavelet space and eliminating data in a space other than a meaningful space, a zero-value prediction expander for restoring data after wavelet transform from compressed data with the data in the space other than the meaningful space being eliminated, a subtracter for making a difference between sub-bands, and a differential accumulation buffer for accumulating the difference. In addition, a decoder is provided to have a zero-value prediction expander and a difference accumulation buffer. The decoder predicts a zero-value in a high frequency component to perform mask processing.
摘要翻译： 图像数据处理装置包括：零值预测压缩器，用于通过从小波空间的低层预测高层的零值区域并消除除了有意义的空间以外的空间中的数据来压缩数据， 用于从除去有意义的空间以外的空间中的数据的压缩数据中恢复小波变换后的数据的值预测扩展器，用于使子带之间产生差异的减法器和用于累积差的差分累积缓冲器。 此外，提供一个解码器以具有零值预测扩展器和差分累积缓冲器。 解码器预测高频分量中的零值以进行掩模处理。
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公开(公告)号：US20100273708A1
公开(公告)日：2010-10-28
申请号：US12762437
申请日：2010-04-19
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , G01N33/6875 , G01N33/74 , G01N33/92 , G01N2500/10 , G01N2800/044
摘要： The present invention provides adiponectin expression-inducing agents, and therapeutic agents using the same for obesity and obesity-related diseases such as cardiovascular diseases or metabolic diseases, as well as methods of searching for adiponectin expression-inducing agents. KLF9, which can bind to the 32-bp fragment of position −188 to position −157 from the adiponectin expression start site, was demonstrated to enhance adiponectin promoter activity. Therefore, the present invention uses KLF9 as an adiponectin expression-inducing agent, and suggests that KLF9 replenishment therapy is useful for preventing and/or treating obesity or obesity-related diseases including metabolic diseases such as insulin resistance and type II diabetes, and cardiovascular diseases.
摘要翻译： 本发明提供了脂联素表达诱导剂和使用其的治疗剂用于肥胖症和肥胖相关疾病如心血管疾病或代谢疾病，以及搜索脂联素表达诱导剂的方法。 KLF9可以结合位点-188的32-bp片段，从脂联素表达起始位点到位置-157，证明增强脂连蛋白启动子活性。 因此，本发明使用KLF9作为脂联素表达诱导剂，并且表明KLF9补充疗法可用于预防和/或治疗肥胖症或肥胖相关疾病，包括诸如胰岛素抵抗和II型糖尿病等代谢疾病和心血管疾病 。
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公开(公告)号：US06785411B1
公开(公告)日：2004-08-31
申请号：US09620648
申请日：2000-07-20
申请人： Shoko Kitajima , Hiroshi Shirouzu , Kanji Yahiro , Koji Yamaguchi
发明人： Shoko Kitajima , Hiroshi Shirouzu , Kanji Yahiro , Koji Yamaguchi
IPC分类号： G06K900
CPC分类号： G06T7/60
摘要： There are provided an image analyzing apparatus and an image analyzing method where, in analyzing a microscopic image of a microbe or a cell tissue, the manpower-independent observation and quantification are executed so as to enhance the analyzing performance. The configuration of the apparatus and the method is as follows: A frequency conversion processing, such as Wavelet transformation, is executed toward the microscopic image of the microbe or the cell tissue and, based on the result obtained, the quantitative analysis is executed. The configuration allows the automatic quantitative judgement to be executed concerning factors such as the position, the number, the magnitude, the degree of activity, the area ratio, the configuration, the direction, and the color. This condition makes it possible to reduce a burden imposed on a person who are in charge of the observation. Also, the noise can be eliminated, which also enhances the analyzing performance. Moreover, the converted regions are utilized for the analysis. This condition makes it possible to execute the analysis with the amount of calculation that is smaller than the resolution, thereby allowing the high-speed processing to be implemented.
摘要翻译： 提供了一种图像分析装置和图像分析方法，其中，在分析微生物或细胞组织的微观图像时，执行人力无关的观察和定量，以提高分析性能。 该装置和方法的结构如下：对微生物或细胞组织的微观图像执行诸如小波变换之类的变频处理，根据获得的结果，进行定量分析。 该配置允许对诸如位置，数量，大小，活动程度，面积比，配置，方向和颜色等因素执行自动定量判断。 这种情况可以减轻负责观察者的负担。 此外，可以消除噪声，这也增强了分析性能。 此外，转换的区域用于分析。 该条件使得可以以小于分辨率的计算量执行分析，从而允许实现高速处理。
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公开(公告)号：US06510251B1
公开(公告)日：2003-01-21
申请号：US09181567
申请日：1998-10-29
申请人： Hiroshi Shirouzu , Shoko Kitajima , Koji Yamaguchi
发明人： Hiroshi Shirouzu , Shoko Kitajima , Koji Yamaguchi
IPC分类号： G06K936
CPC分类号： G06T9/007
摘要： In an image data processing system, an insignificant space estimation unit predicts a significant/insignificant space in a high-frequency subband on the basis of a low-frequency subband signal in a wavelet space. A deletion unit deletes data in the insignificant space which is predicted by the insignificant space estimating unit. Here, the data is contained in the high-frequency subband. An error-estimation detection unit detects presence of significant data in the space predicted to be insignificant by the insignificant space estimation unit. An adding unit adds to output data a significance attribute indicating that significant data exists in the space detected by the error-estimation detection unit.
摘要翻译： 在图像数据处理系统中，无效空间估计单元基于小波空间中的低频子带信号预测高频子带中的有效/无效空间。 删除单元删除由无效空间估计单元预测的无效空间中的数据。 这里，数据被包含在高频子带中。 误差估计检测单元通过无效空间估计单元检测预测为无效的空间中的有效数据的存在。 添加单元向输出数据添加指示在错误估计检测单元检测到的空间中存在有效数据的显着性属性。
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