公开(公告)号：US20080090226A1

公开(公告)日：2008-04-17

申请号：US11954356

申请日：2007-12-12

申请人： John Hackett ,  Julie Yamaguchi ,  Alan Golden ,  Catherine Brennan ,  Robert Hickman ,  Shushil Devare

发明人： John Hackett ,  Julie Yamaguchi ,  Alan Golden ,  Catherine Brennan ,  Robert Hickman ,  Shushil Devare

IPC分类号： C07H21/04 ,  C07K16/00 ,  C12N15/00 ,  C12N5/02 ,  C12Q1/70

CPC分类号： C07K14/005 ,  A61K39/00 ,  C07K2319/00 ,  C12N2740/16122 ,  G01N2333/162

摘要： Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constructs containing additional Group O sequences and especially the gp41 IDR of isolate HAM112. Also claimed are polynucleotide sequences encoding the above, expression vectors comprising the same, host cells transformed thereby, and immunoassay methods and kits utilizing the antigen constructs of the invention.