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    PROCESSES FOR THE PRODUCTION OF POLYMORPHIC FORMS OF RIFAXIMIN
    3.
    发明申请
    PROCESSES FOR THE PRODUCTION OF POLYMORPHIC FORMS OF RIFAXIMIN 审中-公开
    生产RIFAXIMIN多形态的方法

    公开(公告)号：US20120214989A1

    公开(公告)日：2012-08-23

    申请号：US13463714

    申请日：2012-05-03

    申请人： Giuseppe Claudio Viscomi ,  Manuela Campana ,  Dario Braga ,  Donatella Confortini ,  Vincenzo Cannata ,  Paolo Righi ,  Goffredo Rosini

    发明人： Giuseppe Claudio Viscomi ,  Manuela Campana ,  Dario Braga ,  Donatella Confortini ,  Vincenzo Cannata ,  Paolo Righi ,  Goffredo Rosini

    IPC分类号： C07D498/22

    CPC分类号： C07D498/22

    摘要： Crystalline polymorphous forms of rifaximin (INN) antibiotic named rifaximin α and rifaximin β, and a poorly crystalline form named rifaximin γ, useful in the production of medicinal preparations containing rifaximin for oral and topical use and obtained by means of a crystallization carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a determinate temperature and for a determinate period of time, followed by a drying carried out under controlled conditions until reaching a settled water content in the end product, are the object of the invention.

    摘要翻译： 结晶多形态的利福昔明（INN）抗生素名为利福昔明α和利福昔明，并且结晶形式名为利福昔明γ，可用于生产含有利福昔明用于口服和局部使用的药物制剂，并通过结晶进行 将生的利福昔明热溶解在乙醇中，并通过在确定的温度下加入水并在一定的时间内引起产物的结晶，然后在受控条件下进行干燥，直到达到沉淀的含水量 最终产品是本发明的目的。

    Polymorphic forms α, β and γ of rifaximin
    4.
    发明授权
    Polymorphic forms α, β and γ of rifaximin 有权
    多形态α，＆bgr; 和利福昔明的γ

    公开(公告)号：US08158781B2

    公开(公告)日：2012-04-17

    申请号：US13041332

    申请日：2011-03-04

    申请人： Giuseppe Claudio Viscomi ,  Manuela Campana ,  Dario Braga ,  Donatella Confortini ,  Vincenzo Cannata ,  Paolo Righi ,  Goffredo Rosini

    发明人： Giuseppe Claudio Viscomi ,  Manuela Campana ,  Dario Braga ,  Donatella Confortini ,  Vincenzo Cannata ,  Paolo Righi ,  Goffredo Rosini

    IPC分类号： C07D498/22

    CPC分类号： C07D498/22 ,  C07B2200/13 ,  C07D491/22

    摘要： Crystalline polymorphous forms of rifaximin (INN) antibiotic named rifaximin α and rifaximin β, and a poorly crystalline form named rifaximin γ, useful in the production of medicinal preparations containing rifaximin for oral and topical use and obtained by means of a crystallization carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a determinate temperature and for a determinate period of time, followed by a drying carried out under controlled conditions until reaching a settled water content in the end product, are the object of the invention.

    摘要翻译： 结晶多形态的利福昔明（INN）抗生素名为利福昔明α和利福昔明，并且结晶形式名为利福昔明γ，可用于生产含有利福昔明用于口服和局部使用的药物制剂，并通过结晶进行 将生的利福昔明热溶解在乙醇中，并通过在确定的温度下加入水并在一定的时间内引起产物的结晶，然后在受控条件下进行干燥，直到达到沉淀的含水量 最终产品是本发明的目的。

    PROCESS FOR THE PREPARATION OF GABAPENTIN
    7.
    发明申请
    PROCESS FOR THE PREPARATION OF GABAPENTIN 审中-公开
    制备GABAPENTIN的方法

    公开(公告)号：US20090326266A1

    公开(公告)日：2009-12-31

    申请号：US12400080

    申请日：2009-03-09

    申请人： Katiuscia ARRIGHI ,  Vincenzo CANNATA ,  Francesco CORCELLA ,  Gaetano MARCHIORO ,  Andrea NICOLI ,  Maurizio PAIOCCHI ,  Marco VILLA

    发明人： Katiuscia ARRIGHI ,  Vincenzo CANNATA ,  Francesco CORCELLA ,  Gaetano MARCHIORO ,  Andrea NICOLI ,  Maurizio PAIOCCHI ,  Marco VILLA

    IPC分类号： C07C229/28

    CPC分类号： C07C231/02 ,  C07C2601/14 ,  C07C233/08

    摘要： A process for the preparation of 1,1-cyclohexanediacetic acid monoamide comprising the amination of 1,1-cyclohexanediacetic acid anhydride by reaction with aqueous NH3 at a temperature lower than 30° C. by using a NH3/anhydride molar ratio lower than 3, and the product precipitation through the acidification of the reaction mixture; a precipitation process of 1,1-cyclohexanediacetic acid monoamide; and a process for the synthesis of gabapentin comprising the above preparation of 1,1-cyclohexanediacetic acid monoamide, the Hofmann transposition of the same monoamide, the purification of a gabapentin salt and the crystallization from organic solvent.

    摘要翻译： 一种制备1,1-环己烷二乙酸单酰胺的方法，该方法包括使用低于3的NH 3 /酐摩尔比，通过与NH 3水溶液在低于30℃的温度下反应来胺化1,1-环己烷二乙酸酐， 并通过反应混合物酸化产物沉淀; 1,1-环己烷二乙酸单酰胺的沉淀过程; 以及合成加巴喷丁的方法，其包括上述1,1-环己烷二乙酸单酰胺的制备，相同单酰胺的霍夫曼转位，加巴喷丁盐的纯化和有机溶剂的结晶。