公开(公告)号：US20120014975A1

公开(公告)日：2012-01-19

申请号：US13182560

申请日：2011-07-14

Applicant: Martin Hegen ,  Stephane Hubert Olland ,  Yulia Vugmeyster ,  Xin Xu

Inventor： Martin Hegen ,  Stephane Hubert Olland ,  Yulia Vugmeyster ,  Xin Xu

IPC: A61K47/48 ,  G01N33/53 ,  A61B19/00 ,  A61P29/00 ,  A61P37/06 ,  G01N33/566 ,  C07K17/08 ,  A61K49/00

CPC classification number: C07K16/241 ,  A61K47/60 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/40 ,  C07K2317/569 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92

Abstract: The invention relates to modified single domain antigen binding molecules, e.g., SDAB molecules, in particular TNFα-binding SDAB molecules. Method of preparing, and using the modified single domain antigen binding molecules described herein, to treat, e.g., TNFα-associated disorders, are also disclosed.

Abstract translation: 本发明涉及修饰的单结构域抗原结合分子，例如SDAB分子，特别是TNFα结合的SDAB分子。 还公开了制备和使用本文所述的修饰的单结构域抗原结合分子来治疗例如TNFα相关疾病的方法。

公开(公告)号：US07625731B2

公开(公告)日：2009-12-01

申请号：US11467138

申请日：2006-08-24

Applicant: Lydia Mosyak ,  Thomas Saltmarsh Rush, III ,  Stephane Hubert Olland ,  Edward R. LaVallie ,  Lisa A. Collins-Racie ,  Christopher John Corcoran ,  Stewart Andrews Mackie

Inventor： Lydia Mosyak ,  Thomas Saltmarsh Rush, III ,  Stephane Hubert Olland ,  Edward R. LaVallie ,  Lisa A. Collins-Racie ,  Christopher John Corcoran ,  Stewart Andrews Mackie

IPC: C12N9/00 ,  C12N11/16 ,  C12N9/14 ,  C12N9/48 ,  C12N9/50 ,  C12N9/64

CPC classification number: C12N9/6421 ,  C07K2299/00 ,  C30B7/00

Abstract: This invention relates to aggrecanase polypeptides and aggrecanase polypeptide/ligand complexes, crystals of aggrecanase and aggrecanase polypeptide/ligand complexes, and related methods and software systems.

公开(公告)号：US07615363B2

公开(公告)日：2009-11-10

申请号：US11467135

申请日：2006-08-24

Applicant: Lidia Mosyak ,  Thomas Saltmarsh Rush, III ,  Xiaotian Zhong ,  Thomas E. McDonagh ,  Katy E. Georgiadis ,  Phaik-Eng Sum ,  Edward R. LaVallie ,  Lisa A. Collins-Racie ,  Christopher John Corcoran ,  Ravindra Kumar ,  Tracy Hebert ,  Stephane Hubert Olland ,  Stewart Andrews Mackie

Inventor： Lidia Mosyak ,  Thomas Saltmarsh Rush, III ,  Xiaotian Zhong ,  Thomas E. McDonagh ,  Katy E. Georgiadis ,  Phaik-Eng Sum ,  Edward R. LaVallie ,  Lisa A. Collins-Racie ,  Christopher John Corcoran ,  Ravindra Kumar ,  Tracy Hebert ,  Stephane Hubert Olland ,  Stewart Andrews Mackie

IPC: C12N9/00 ,  G01N31/00

CPC classification number: C12N9/6421 ,  C07K2299/00 ,  C07K2319/00

Abstract: This invention relates to aggrecanase polypeptides and aggrecanase polypeptide/ligand complexes, crystals of aggrecanase and aggrecanase polypeptide/ligand complexes, and related methods and software systems.

Abstract translation: 本发明涉及聚集蛋白聚糖酶多肽和聚集蛋白聚糖蛋白聚糖酶多肽/配体复合物，聚集蛋白聚糖蛋白聚糖酶和聚集蛋白聚糖酶多肽/配体复合物的晶体，以及相关的方法和软件系统。