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公开(公告)号：US20120264919A1
公开(公告)日：2012-10-18
申请号：US13453090
申请日：2012-04-23
申请人： Laird BLOOM , Davinder GILL , Yulia VUGMEYSTER , Deborah A. YOUNG , David LOWE , Viia VALGE-ARCHER
发明人： Laird BLOOM , Davinder GILL , Yulia VUGMEYSTER , Deborah A. YOUNG , David LOWE , Viia VALGE-ARCHER
CPC分类号： C07K14/54 , C07K16/2866 , C07K2317/21 , C07K2317/52 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/92
摘要： The present invention provides binding proteins and antigen-binding fragments thereof that specifically bind to the human interleukin-21 receptor (IL-21R). The binding proteins can act as, e.g., antagonists of IL-21R activity, thereby modulating immune responses in general, and those mediated by IL-21R in particular. The disclosed compositions and methods may be used, e.g., in diagnosing and/or treating IL-21R-associated disorders, e.g., inflammatory disorders, autoimmune diseases, allergies, transplant rejection, cancer, and other immune system disorders.
摘要翻译： 本发明提供与人白细胞介素-21受体（IL-21R）特异性结合的结合蛋白及其抗原结合片段。 结合蛋白可以作为例如IL-21R活性的拮抗剂，从而调节一般的免疫应答，特别是由IL-21R介导的那些。 所公开的组合物和方法可用于例如诊断和/或治疗IL-21R相关疾病，例如炎症性疾病，自身免疫疾病，过敏反应，移植排斥反应，癌症和其他免疫系统疾病。
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2.发明申请METHODS OF TREATMENT UTILIZIING BINDING PROTEINS OF THE INTERLEUKIN-21 RECEPTOR 审中-公开利用INTERLEUKIN-21受体使用结合蛋白的方法公开(公告)号：US20120276102A1
公开(公告)日：2012-11-01
申请号：US13470500
申请日：2012-05-14
申请人： Laird BLOOM , Davinder GILL , Yulia VUGMEYSTER , Deborah A. YOUNG , Margot O'TOOLE , Heath M. GUAY , Karissa K. ADKINS , Amy Arlene WEAVER , Sadhana JAIN , Maya ARAI
发明人： Laird BLOOM , Davinder GILL , Yulia VUGMEYSTER , Deborah A. YOUNG , Margot O'TOOLE , Heath M. GUAY , Karissa K. ADKINS , Amy Arlene WEAVER , Sadhana JAIN , Maya ARAI
IPC分类号： A61K39/395 , A61P29/00 , A61P37/08 , A61P35/00 , C12Q1/68 , A61P17/06 , A61P19/02 , G01N33/566 , G01N21/76 , A61P37/06 , A61P25/00
CPC分类号： G01N33/6869 , A61K38/00 , A61K2039/505 , C07K16/2866 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N2333/54
摘要： The present invention provides binding proteins and antigen-binding fragments thereof, including human antibodies, that specifically bind to the human interleukin-21 receptor (IL-21R), and methods of using them. The binding proteins can act as, e.g., antagonists of IL-21R activity, thereby modulating immune responses in general, and those mediated by IL-21R in particular. The disclosed compositions and methods may be used, e.g., in diagnosing, treating, and/or preventing IL-21R-associated disorders, e.g., inflammatory disorders, autoimmune diseases, allergies, transplant rejection, and other immune system disorders.
摘要翻译： 本发明提供特异性结合人白细胞介素-21受体（IL-21R）的结合蛋白及其抗原结合片段，包括人抗体，以及使用它们的方法。 结合蛋白可以作为例如IL-21R活性的拮抗剂，从而调节一般的免疫应答，特别是由IL-21R介导的那些。 所公开的组合物和方法可以用于例如诊断，治疗和/或预防IL-21R相关疾病，例如炎性疾病，自身免疫疾病，过敏，移植排斥和其它免疫系统疾病。
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公开(公告)号：US08163884B2
公开(公告)日：2012-04-24
申请号：US12472209
申请日：2009-05-26
申请人： Laird Bloom , Davinder Gill , Yulia Vugmeyster , Deborah A. Young , David Lowe , Viia Valge-Archer
发明人： Laird Bloom , Davinder Gill , Yulia Vugmeyster , Deborah A. Young , David Lowe , Viia Valge-Archer
IPC分类号： C07K16/28 , A61K39/00 , A61K39/395 , C12P21/02
CPC分类号： C07K14/54 , C07K16/2866 , C07K2317/21 , C07K2317/52 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/92
摘要： The present invention provides binding proteins and antigen-binding fragments thereof that specifically bind to the human interleukin-21 receptor (IL-21R). The binding proteins can act as, e.g., antagonists of IL-21R activity, thereby modulating immune responses in general, and those mediated by IL-21R in particular. The disclosed compositions and methods may be used, e.g., in diagnosing and/or treating IL-21R-associated disorders, e.g., inflammatory disorders, autoimmune diseases, allergies, transplant rejection, cancer, and other immune system disorders.
摘要翻译： 本发明提供与人白细胞介素-21受体（IL-21R）特异性结合的结合蛋白及其抗原结合片段。 结合蛋白可以作为例如IL-21R活性的拮抗剂，从而调节一般的免疫应答，特别是由IL-21R介导的那些。 所公开的组合物和方法可用于例如诊断和/或治疗IL-21R相关疾病，例如炎症性疾病，自身免疫疾病，过敏反应，移植排斥反应，癌症和其他免疫系统疾病。
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4.发明申请METHODS OF TREATMENT UTILIZING BINDING PROTEINS OF THE INTERLEUKIN-21 RECEPTOR 失效利用INTERLEUKIN-21受体结合蛋白的治疗方法公开(公告)号：US20090298081A1
公开(公告)日：2009-12-03
申请号：US12472237
申请日：2009-05-26
申请人： Laird BLOOM , Davinder GILL , Yulia VUGMEYSTER , Deborah A. YOUNG , Margot O'TOOLE , Heath M. GUAY , Karissa K. ADKINS , Amy Arlene WEAVER , Sadhana JAIN , Maya ARAI
发明人： Laird BLOOM , Davinder GILL , Yulia VUGMEYSTER , Deborah A. YOUNG , Margot O'TOOLE , Heath M. GUAY , Karissa K. ADKINS , Amy Arlene WEAVER , Sadhana JAIN , Maya ARAI
IPC分类号： C12Q1/68 , A61K39/395
CPC分类号： G01N33/6869 , A61K38/00 , A61K2039/505 , C07K16/2866 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N2333/54
摘要： The present invention provides binding proteins and antigen-binding fragments thereof, including human antibodies, that specifically bind to the human interleukin-21 receptor (IL-21R), and methods of using them. The binding proteins can act as, e.g., antagonists of IL-21R activity, thereby modulating immune responses in general, and those mediated by IL-21R in particular. The disclosed compositions and methods may be used, e.g., in diagnosing, treating, and/or preventing IL-21R-associated disorders, e.g., inflammatory disorders, autoimmune diseases, allergies, transplant rejection, and other immune system disorders.
摘要翻译： 本发明提供特异性结合人白细胞介素-21受体（IL-21R）的结合蛋白及其抗原结合片段，包括人抗体，以及使用它们的方法。 结合蛋白可以作为例如IL-21R活性的拮抗剂，从而调节一般的免疫应答，特别是由IL-21R介导的那些。 所公开的组合物和方法可以用于例如诊断，治疗和/或预防IL-21R相关疾病，例如炎性疾病，自身免疫疾病，过敏，移植排斥和其它免疫系统疾病。
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5.发明申请METHODS AND COMPOSITIONS FOR TREATING AND MONITORING TREATMENT OF IL-13-ASSOCIATED DISORDERS 审中-公开用于治疗和监测IL-13相关疾病的方法和组合物公开(公告)号：US20090068195A1
公开(公告)日：2009-03-12
申请号：US12107456
申请日：2008-04-22
申请人： Yulia Vugmeyster , Xin Xu , Xianbin Tian , Donald G. Raible , Yuji Simon Zhou , Billie Durn
发明人： Yulia Vugmeyster , Xin Xu , Xianbin Tian , Donald G. Raible , Yuji Simon Zhou , Billie Durn
IPC分类号： A61K39/395 , G06F19/00 , A61P11/00 , A61P29/00 , A61P35/00
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , G01N33/6854 , Y02A90/26
摘要： Methods and compositions for reducing or inhibiting, or preventing or delaying the onset of, one or more symptoms associated with an early and/or a late phase of an IL-13-associated disorder or condition using IL-13 binding agents are disclosed. Methods for evaluating the kinetics and/or efficacy of an IL-13 binding agent in treating or preventing an IL-13-associated disorder or condition in a subject, e.g., a human subject, are also disclosed.
摘要翻译： 公开了用于减少或抑制或预防或延迟与IL-13相关疾病或病症的早期和/或晚期相关的一种或多种症状的使用IL-13结合剂的方法和组合物。 还公开了用于评价IL-13结合剂在治疗或预防受试者例如人受试者中的IL-13相关障碍或病症的动力学和/或功效的方法。
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6.发明授权Methods of treatment utilizing binding proteins of the interleukin-21 receptor 失效使用白细胞介素-21受体结合蛋白的治疗方法公开(公告)号：US08178097B2
公开(公告)日：2012-05-15
申请号：US12472237
申请日：2009-05-26
申请人： Laird Bloom , Davinder Gill , Yulia Vugmeyster , Deborah A. Young , Margot O'Toole , Heath M. Guay , Karissa K. Adkins , Amy Arlene Weaver , Sadhana Jain , Maya Arai
发明人： Laird Bloom , Davinder Gill , Yulia Vugmeyster , Deborah A. Young , Margot O'Toole , Heath M. Guay , Karissa K. Adkins , Amy Arlene Weaver , Sadhana Jain , Maya Arai
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： G01N33/6869 , A61K38/00 , A61K2039/505 , C07K16/2866 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N2333/54
摘要： The present invention provides binding proteins and antigen-binding fragments thereof, including human antibodies, that specifically bind to the human interleukin-21 receptor (IL-21R), and methods of using them. The binding proteins can act as, e.g., antagonists of IL-21R activity, thereby modulating immune responses in general, and those mediated by IL-21R in particular. The disclosed compositions and methods may be used, e.g., in diagnosing, treating, and/or preventing IL-21R-associated disorders, e.g., inflammatory disorders, autoimmune diseases, allergies, transplant rejection, and other immune system disorders.
摘要翻译： 本发明提供特异性结合人白细胞介素-21受体（IL-21R）的结合蛋白及其抗原结合片段，包括人抗体，以及使用它们的方法。 结合蛋白可以作为例如IL-21R活性的拮抗剂，从而调节一般的免疫应答，特别是由IL-21R介导的那些。 所公开的组合物和方法可以用于例如诊断，治疗和/或预防IL-21R相关疾病，例如炎性疾病，自身免疫疾病，过敏，移植排斥和其它免疫系统疾病。
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公开(公告)号：US20120014975A1
公开(公告)日：2012-01-19
申请号：US13182560
申请日：2011-07-14
申请人： Martin Hegen , Stephane Hubert Olland , Yulia Vugmeyster , Xin Xu
发明人： Martin Hegen , Stephane Hubert Olland , Yulia Vugmeyster , Xin Xu
IPC分类号： A61K47/48 , G01N33/53 , A61B19/00 , A61P29/00 , A61P37/06 , G01N33/566 , C07K17/08 , A61K49/00
CPC分类号： C07K16/241 , A61K47/60 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/40 , C07K2317/569 , C07K2317/76 , C07K2317/90 , C07K2317/92
摘要： The invention relates to modified single domain antigen binding molecules, e.g., SDAB molecules, in particular TNFα-binding SDAB molecules. Method of preparing, and using the modified single domain antigen binding molecules described herein, to treat, e.g., TNFα-associated disorders, are also disclosed.
摘要翻译： 本发明涉及修饰的单结构域抗原结合分子，例如SDAB分子，特别是TNFα结合的SDAB分子。 还公开了制备和使用本文所述的修饰的单结构域抗原结合分子来治疗例如TNFα相关疾病的方法。
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公开(公告)号：US20090298167A1
公开(公告)日：2009-12-03
申请号：US12472209
申请日：2009-05-26
申请人： Laird BLOOM , Davinder GILL , Yulia VUGMEYSTER , Deborah A. YOUNG , David LOWE , Viia VALGE-ARCHER
发明人： Laird BLOOM , Davinder GILL , Yulia VUGMEYSTER , Deborah A. YOUNG , David LOWE , Viia VALGE-ARCHER
CPC分类号： C07K14/54 , C07K16/2866 , C07K2317/21 , C07K2317/52 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/92
摘要： The present invention provides binding proteins and antigen-binding fragments thereof that specifically bind to the human interleukin-21 receptor (IL-21R). The binding proteins can act as, e.g., antagonists of IL-21R activity, thereby modulating immune responses in general, and those mediated by IL-21R in particular. The disclosed compositions and methods may be used, e.g., in diagnosing and/or treating IL-21R-associated disorders, e.g., inflammatory disorders, autoimmune diseases, allergies, transplant rejection, cancer, and other immune system disorders.
摘要翻译： 本发明提供与人白细胞介素-21受体（IL-21R）特异性结合的结合蛋白及其抗原结合片段。 结合蛋白可以作为例如IL-21R活性的拮抗剂，从而调节一般的免疫应答，特别是由IL-21R介导的那些。 所公开的组合物和方法可用于例如诊断和/或治疗IL-21R相关疾病，例如炎症性疾病，自身免疫疾病，过敏反应，移植排斥反应，癌症和其他免疫系统疾病。
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