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1.发明申请Methods for evaluating tissue pair combinations for use in nucleic acid array technology 审中-公开评估用于核酸阵列技术的组织对组合的方法公开(公告)号：US20050112584A1
公开(公告)日：2005-05-26
申请号：US10718342
申请日：2003-11-20
CPC分类号： G16B25/00
摘要： Methods are disclosed for selecting a combination of nucleic acid sample pairs for evaluating the ability of an oligonucleotide probe to measure differential expression of genes. Differential gene expression experiments are conducted using (i) nucleic acid sample pairs and (ii) nucleic acid probes immobilized on a substrate, the probes representing a set of genes. The number of genes in the set is a portion of an expected number of genes in a sample. A nucleic acid sample pair combination is selected based on the members of the combination having a maximized number of genes from the set of genes that exhibit differential expression and a minimized number of the genes that do not exhibit differential expression.
摘要翻译： 公开了用于选择核酸样品对的组合以评估寡核苷酸探针以测量基因差异表达的能力的方法。 使用（i）核酸样品对和（ii）固定在底物上的核酸探针进行差异基因表达实验，探针代表一组基因。 该组中的基因数目是样品中预期基因数量的一部分。 基于组合的成员选择核酸样品对组合，其具有来自显示差异表达的基因组的最大数量的基因和不显示差异表达的基因的最小数目。
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公开(公告)号：US20070219727A1
公开(公告)日：2007-09-20
申请号：US11378661
申请日：2006-03-17
IPC分类号： G06F19/00
摘要： Comparative genomic hybridization is a tool that compares DNA samples from suspect cells of an organism with DNA samples from normal cells. Cross-species comparative genomic hybridization visualization allows genomic data from model organisms to be mapped and presented in accordance with the (for example) human genome to suggest possible common biological effects between two or more species.
摘要翻译： 比较基因组杂交是将生物体的可疑细胞的DNA样品与来自正常细胞的DNA样品进行比较的工具。 跨物种比较基因组杂交可视化允许来自模型生物体的基因组数据根据（例如）人类基因组进行绘制和呈现，以提出两种或多种物种之间可能的常见生物学效应。
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公开(公告)号：US20070141584A1
公开(公告)日：2007-06-21
申请号：US11313522
申请日：2005-12-20
CPC分类号： C12Q1/6837 , C12Q2521/301
摘要： A method for determining chromatin accessibility of nucleic acids in a cell by expressing an effective amount of a nuclease in a cell to digest chromatin at chromatin accessible sites to form chromatin fragments; isolating chromatin fragments from the cell; and hybridizing the chromatin fragments on a microarray to determine the location and/or sequence of the chromatin fragments.
摘要翻译： 一种通过在细胞中表达有效量的核酸酶以消化染色质可接近部位的染色质以形成染色质片段来确定细胞中核酸的染色质可及性的方法; 从细胞中分离染色质片段; 并在微阵列上杂交染色质片段以确定染色质片段的位置和/或序列。
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公开(公告)号：US20070092869A1
公开(公告)日：2007-04-26
申请号：US11580675
申请日：2006-10-13
CPC分类号： C12Q1/6837 , G16B25/00 , C12Q2565/513
摘要： Methods, compositions, and kits for performing a one-color analysis of microarray data are provided. Also disclosed are compositions including control nucleic acid sequences, and methods for measuring the dynamic range of a microarray analysis.
摘要翻译： 提供了用于进行微阵列数据的单色分析的方法，组合物和试剂盒。 还公开了包含对照核酸序列的组合物和用于测量微阵列分析的动态范围的方法。
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公开(公告)号：US20060078889A1
公开(公告)日：2006-04-13
申请号：US10961991
申请日：2004-10-08
CPC分类号： C12Q1/6837 , C12Q1/6865 , C12Q2565/525 , C12Q2565/537 , C12Q2531/143
摘要： Methods and compositions for generating pluralities of ribonucleic acids are provided. In the subject methods, an array is employed as a template in an in vitro transcription reaction. Also provided are the arrays employed in the subject methods and kits for practicing the subject methods. The ribonucleic acid pluralities produced by the subject methods find use in a variety of different applications, including differential gene expression analysis and gene-silencing applications.
摘要翻译： 提供了产生多种核糖核酸的方法和组合物。 在本方法中，在体外转录反应中使用阵列作为模板。 还提供了用于实践本发明方法的主题方法和试剂盒中使用的阵列。 通过本发明方法产生的核糖核酸多样性可用于各种不同的应用，包括差异基因表达分析和基因沉默应用。
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公开(公告)号：US20070092903A1
公开(公告)日：2007-04-26
申请号：US11580581
申请日：2006-10-13
CPC分类号： C12Q1/6837 , C12Q2565/102
摘要： Microarray platforms for performing one-color and two color analyses using a single platform are provided. Methods of using the microarray platforms and analyzing data obtained from such microarrays are also provided.
摘要翻译： 提供了使用单个平台执行单色和双色分析的微阵列平台。 还提供了使用微阵列平台和分析从这样的微阵列获得的数据的方法。
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7.发明申请公开(公告)号：US20050282174A1
公开(公告)日：2005-12-22
申请号：US10871303
申请日：2004-06-19
摘要： Methods and systems for identifying and selecting nucleic acid probes for detecting a target with a nucleic acid probe array or microarray, comprising selecting a plurality of candidate probes, forming a plurality of clusters from the plurality of candidate probes according to hybridization characteristics of the candidate probes, forming at least one SuperCluster from the clusters; and selecting at least one probe from each SuperCluster for the probe array.
摘要翻译： 用于鉴定和选择用于用核酸探针阵列或微阵列检测靶的核酸探针的方法和系统，包括根据候选探针的杂交特征选择多个候选探针，从多个候选探针形成多个簇 ，从簇中形成至少一个超级簇; 并从每个SuperCluster中为探针阵列选择至少一个探针。
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