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    Ultrasound-guided near infrared spectrophotometer
    2.
    发明授权
    Ultrasound-guided near infrared spectrophotometer 失效
    超声波引导近红外分光光度计

    公开(公告)号：US06690958B1

    公开(公告)日：2004-02-10

    申请号：US10143248

    申请日：2002-05-07

    申请人： Stephen D. Walker ,  Peter E. Nelson ,  R. Dale Zellers

    发明人： Stephen D. Walker ,  Peter E. Nelson ,  R. Dale Zellers

    IPC分类号： A61B500

    CPC分类号： A61B5/1464 ,  A61B5/14542 ,  A61B5/6853 ,  A61B8/0808 ,  A61B8/0866 ,  A61B8/12 ,  A61B8/4416 ,  A61B8/445 ,  A61B2562/0233 ,  A61B2562/0242 ,  A61B2562/043

    摘要： A diagnostic apparatus includes a near infrared spectrophotometer (NIRS) and an ultrasound transducer that operate in combination to improve diagnostic measurements. The diagnostic apparatus includes a near infrared spectrophotometer that measures an analyte, for example tissue oxygenation, in an optical sample volume and an ultrasound imager to accurately position the optical sample volume in biological tissue or vessels. In one example, the diagnostic apparatus includes an optical source, a linear array of ultrasound transducers, and an optical photodetector arranged in the same plane so that the ultrasound sample volume interrogated by the ultrasound transducers intersects the optical sample volume formed by the optical source and detector.

    摘要翻译： 诊断装置包括近红外分光光度计（NIRS）和超声波换能器，其组合操作以改善诊断测量。 诊断装置包括近红外分光光度计，其测量光学样本体积中的分析物例如组织氧合，以及超声波成像器，以将光学样本体积精确地定位在生物组织或血管中。 在一个示例中，诊断装置包括光源，超声波换能器的线性阵列和布置在同一平面中的光学检测器，使得由超声波换能器询问的超声波样品体积与由光源形成的光学样本体积相交， 探测器。

    Noninvasive optical sensor for measuring near infrared light absorbing analytes
    4.
    发明授权
    Noninvasive optical sensor for measuring near infrared light absorbing analytes 失效
    用于测量近红外光吸收分析物的无创光学传感器

    公开(公告)号：US06802812B1

    公开(公告)日：2004-10-12

    申请号：US09917414

    申请日：2001-07-27

    申请人： Stephen D. Walker ,  John E. Repine ,  Charles W. Henry ,  Harry L. Valenta, Jr. ,  Peter E. Nelson ,  R. Dale Zellers

    发明人： Stephen D. Walker ,  John E. Repine ,  Charles W. Henry ,  Harry L. Valenta, Jr. ,  Peter E. Nelson ,  R. Dale Zellers

    IPC分类号： A61B500

    CPC分类号： A61B5/412 ,  A61B5/02028 ,  A61B5/0261 ,  A61B5/14553 ,  A61B5/413 ,  A61B5/7275 ,  A61B2562/028

    摘要： An optical sensor includes an optical source capable of being positioned on a tissue and emitting near infrared light into the tissue at a plurality of selected wavelengths, and a photodetector capable of detecting reflected light from the tissue. The photodetector being positioned on the tissue removed from the optical source but sufficiently close in proximity to the optical source to contact the same general tissue. The optical sensor further includes an oscillator coupled to the optical source and capable of activating the optical source to emit the near infrared light, and a modulator coupled to the oscillator and capable of controlling radio frequency modulation of the optical source to emit a radio frequency component that is used to measure the optical path length and absorbance of an analyte of interest within the tissue.

    摘要翻译： 光学传感器包括能够定位在组织上并以多个选定波长将近红外光发射到组织中的光源，以及能够检测来自组织的反射光的光电检测器。 光电检测器定位在从光源移除的组织上，但是在光源附近充分接近以接触相同的一般组织。 光学传感器还包括耦合到光源并且能够激活光源以发射近红外光的振荡器，以及耦合到振荡器并且能够控制光源的射频调制以发射射频分量的振荡器 其用于测量组织内感兴趣的分析物的光程长度和吸光度。

    LACTATE CONCENTRATION MEASUREMENT DEVICE
    5.
    发明申请
    LACTATE CONCENTRATION MEASUREMENT DEVICE 审中-公开
    LACTATE浓度测量装置

    公开(公告)号：US20090047177A1

    公开(公告)日：2009-02-19

    申请号：US11840528

    申请日：2007-08-17

    申请人： Stephen D. Walker ,  Devon J. Dallmann ,  Charles W. Henry ,  Peter E. Nelson ,  R. Dale Zellers ,  John E. Repine

    发明人： Stephen D. Walker ,  Devon J. Dallmann ,  Charles W. Henry ,  Peter E. Nelson ,  R. Dale Zellers ,  John E. Repine

    IPC分类号： G01N21/00 ,  G01N33/48

    CPC分类号： G01N21/314 ,  G01N21/35 ,  G01N2021/3166

    摘要： A lactate concentration measurement apparatus comprising a housing enclosing a sample chamber configured for holding a body fluid sample and measurement photo-optics that generate light and monitor light intensity along a plurality of optical paths in the sample chamber. The apparatus further comprises a plurality of optical filters aligned in respective optical paths of the optical path plurality comprising at least a first optical filter with light absorption by lactate and water and a second optical filter with light absorption to water alone. A logic determines lactate concentration based on a ratio of intensities detected at a first detector in an optical path intersected by the first optical filter and detected at a second detector in an optical path intersected by the second optical filter.

    摘要翻译： 一种乳酸盐浓度测量装置，包括：壳体，其包围被构造成用于保持体液样本的样本室，以及测量光学光学器件，其产生光并沿着样本室中的多个光路监测光强度。 该装置还包括多个光学滤光器，该多个光学滤光器在光路的各个光路中排列成多个，至少包括具有乳酸和水的光吸收的第一滤光器以及仅对水单独吸收光的第二滤光器。 逻辑根据在与第一滤光器相交的光路中的第一检测器检测到的强度的比值确定乳酸浓度，并且在与第二滤光器相交的光路中的第二检测器处检测。

    Analyte Concentration Measurement Device
    6.
    发明申请
    Analyte Concentration Measurement Device 审中-公开
    分析物浓度测定装置

    公开(公告)号：US20090018416A1

    公开(公告)日：2009-01-15

    申请号：US11777940

    申请日：2007-07-13

    申请人： Stephen D. Walker ,  Devon J. Dallmann ,  Charles W. Henry ,  Peter E. Nelson ,  R. Dale Zellers ,  John E. Repine

    发明人： Stephen D. Walker ,  Devon J. Dallmann ,  Charles W. Henry ,  Peter E. Nelson ,  R. Dale Zellers ,  John E. Repine

    IPC分类号： A61B5/00

    CPC分类号： G01N21/314 ,  A61B5/14532 ,  G01N21/35

    摘要： A method for measuring concentration of an analyte in body fluid comprises acquiring a body fluid sample, emitting light into the body fluid sample, and detecting emitted light intensity on a plurality of optical paths through the body fluid sample. A plurality of optical filters are arranged in respective optical paths of the optical path plurality comprising at least a first optical filter with light absorption by an analyte and water and a second optical filter with light absorption to water alone. Light intensity passed through the first optical filter and passed through the second optical filter is measured and analyte concentration is determined based on a ratio of intensities detected at a detector in an optical path intersected by the first optical filter and detected at a detector in an optical path intersected by the second optical filter.

    摘要翻译： 用于测量体液中分析物浓度的方法包括获取体液样品，将光发射到体液样品中，以及检测通过体液样品的多条光路上的发射光强度。 多个光学滤光器被布置在包括至少一个具有被分析物和水的光吸收的第一滤光器的光路的多个光路中，以及仅对水单独吸收光的第二滤光器。 测量通过第一滤光器并通过第二滤光器的光强度，并且基于在由第一滤光器相交的光路中的检测器处检测到的强度的比率确定分析物浓度，并在光学检测器中检测 路径与第二光学滤波器相交。

    VCSEL Tissue Spectrometer
    7.
    发明申请
    VCSEL Tissue Spectrometer 审中-公开
    VCSEL组织光谱仪

    公开(公告)号：US20080004513A1

    公开(公告)日：2008-01-03

    申请号：US11428217

    申请日：2006-06-30

    申请人： Stephen D. Walker ,  Peter E. Nelson ,  R. Dale Zellers ,  Charles W. Henry ,  John E. Repine

    发明人： Stephen D. Walker ,  Peter E. Nelson ,  R. Dale Zellers ,  Charles W. Henry ,  John E. Repine

    IPC分类号： A61B5/00

    CPC分类号： A61B5/14532 ,  A61B5/1455 ,  A61B5/412 ,  A61B2562/0233 ,  A61B2562/043

    摘要： In a tissue sensor, a plurality of emitters are configured to emit narrowband light into biological tissue at a plurality of selected wavelengths including one or more wavelengths indicative of a profile for one or more selected analytes and a reference wavelength at which absorbance for the selected analyte is negligible. The sensor further comprises a photo detector configured to detect light at wavelengths that emerge from the biological tissue.

    摘要翻译： 在组织传感器中，多个发射器被配置为以多个选定的波长将窄带光发射到生物组织中，所述多个选定波长包括一个或多个波长，其指示一个或多个所选分析物的分布，以及所选分析物的吸光度 是微不足道的 传感器还包括被配置为检测从生物组织出现的波长处的光的光检测器。

    Cerebral oxygenation monitor
    9.
    发明授权
    Cerebral oxygenation monitor 失效
    脑氧合监测仪

    公开(公告)号：US06453183B1

    公开(公告)日：2002-09-17

    申请号：US09545916

    申请日：2000-04-10

    申请人： Stephen D. Walker

    发明人： Stephen D. Walker

    IPC分类号： A61B500

    CPC分类号： A61B5/14553 ,  A61B5/1464

    摘要： A method and apparatus for determining oxygenation and hemoglobin parameters in tissue measures light scattering parameters of light directed through the tissue, using an array of VCSELs, for light directed at more than one frequency. This allows for the calculation of Hb, HbO2, and other parameters.

    摘要翻译： 用于测定组织中的氧合作用和血红蛋白参数的方法和装置通过使用VCSEL阵列测量针对多于一个频率的光来测量穿过组织的光的光散射参数。 这允许计算Hb，HbO2和其他参数。

    Method and apparatus for measuring gas concentration using a semiconductor laser
    10.
    发明授权
    Method and apparatus for measuring gas concentration using a semiconductor laser 失效
    使用半导体激光器测量气体浓度的方法和装置

    公开(公告)号：US6091504A

    公开(公告)日：2000-07-18

    申请号：US82662

    申请日：1998-05-21

    申请人： Stephen D. Walker ,  Robert A. Nichols ,  William A. Curnan ,  Sophat Svai ,  James R. Braig ,  Daniel S. Goldberger

    发明人： Stephen D. Walker ,  Robert A. Nichols ,  William A. Curnan ,  Sophat Svai ,  James R. Braig ,  Daniel S. Goldberger

    IPC分类号： G01N21/39 ,  G01N21/00

    CPC分类号： G01N21/39

    摘要： A system and method for determining the concentration of an analyte such as oxygen in an unknown gas sample. A Vertical Cavity Surface Emitting Laser (VCSEL) is used as a variable wavelength light source which is "swept" through a wavelength range by varying the drive signal applied thereto. Quantitative spectroscopic analysis of the unknown gas sample is performed without the requirement of feedback circuitry for tuning the light source to the characteristic frequency of an analyte. Instead, the VCSEL is repeatedly "swept" through a range of frequencies determined by the drive signal, and the absorption is measured by the detector. The absorption lines do not always occur at the same place but instead move along around during the sweep based on the temperature and baseline current. The absorption at a particular wavelength may be determined by overlaying the drive signal and its timing information over the detected absorption signal.

    摘要翻译： 用于确定未知气体样品中分析物如氧的浓度的系统和方法。 垂直腔面发射激光器（VCSEL）被用作通过改变施加到其上的驱动信号通过波长范围“扫过”的可变波长光源。 进行未知气体样品的定量光谱分析，而不需要用于将光源调谐到分析物的特征频率的反馈电路。 相反，VCSEL在由驱动信号确定的频率范围内被重复扫描，并且由检测器测量吸收。 吸收线并不总是发生在相同的位置，而是基于温度和基线电流在扫描过程中沿着周围移动。 可以通过将驱动信号及其定时信息覆盖在检测到的吸收信号上来确定特定波长处的吸收。