利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

14 条记录 (耗时 0.026 秒)

    Noninvasive optical sensor for measuring near infrared light absorbing analytes
    3.
    发明授权
    Noninvasive optical sensor for measuring near infrared light absorbing analytes 失效
    用于测量近红外光吸收分析物的无创光学传感器

    公开(公告)号：US06802812B1

    公开(公告)日：2004-10-12

    申请号：US09917414

    申请日：2001-07-27

    申请人： Stephen D. Walker ,  John E. Repine ,  Charles W. Henry ,  Harry L. Valenta, Jr. ,  Peter E. Nelson ,  R. Dale Zellers

    发明人： Stephen D. Walker ,  John E. Repine ,  Charles W. Henry ,  Harry L. Valenta, Jr. ,  Peter E. Nelson ,  R. Dale Zellers

    IPC分类号： A61B500

    CPC分类号： A61B5/412 ,  A61B5/02028 ,  A61B5/0261 ,  A61B5/14553 ,  A61B5/413 ,  A61B5/7275 ,  A61B2562/028

    摘要： An optical sensor includes an optical source capable of being positioned on a tissue and emitting near infrared light into the tissue at a plurality of selected wavelengths, and a photodetector capable of detecting reflected light from the tissue. The photodetector being positioned on the tissue removed from the optical source but sufficiently close in proximity to the optical source to contact the same general tissue. The optical sensor further includes an oscillator coupled to the optical source and capable of activating the optical source to emit the near infrared light, and a modulator coupled to the oscillator and capable of controlling radio frequency modulation of the optical source to emit a radio frequency component that is used to measure the optical path length and absorbance of an analyte of interest within the tissue.

    摘要翻译： 光学传感器包括能够定位在组织上并以多个选定波长将近红外光发射到组织中的光源，以及能够检测来自组织的反射光的光电检测器。 光电检测器定位在从光源移除的组织上，但是在光源附近充分接近以接触相同的一般组织。 光学传感器还包括耦合到光源并且能够激活光源以发射近红外光的振荡器，以及耦合到振荡器并且能够控制光源的射频调制以发射射频分量的振荡器 其用于测量组织内感兴趣的分析物的光程长度和吸光度。

    LACTATE CONCENTRATION MEASUREMENT DEVICE
    4.
    发明申请
    LACTATE CONCENTRATION MEASUREMENT DEVICE 审中-公开
    LACTATE浓度测量装置

    公开(公告)号：US20090047177A1

    公开(公告)日：2009-02-19

    申请号：US11840528

    申请日：2007-08-17

    申请人： Stephen D. Walker ,  Devon J. Dallmann ,  Charles W. Henry ,  Peter E. Nelson ,  R. Dale Zellers ,  John E. Repine

    发明人： Stephen D. Walker ,  Devon J. Dallmann ,  Charles W. Henry ,  Peter E. Nelson ,  R. Dale Zellers ,  John E. Repine

    IPC分类号： G01N21/00 ,  G01N33/48

    CPC分类号： G01N21/314 ,  G01N21/35 ,  G01N2021/3166

    摘要： A lactate concentration measurement apparatus comprising a housing enclosing a sample chamber configured for holding a body fluid sample and measurement photo-optics that generate light and monitor light intensity along a plurality of optical paths in the sample chamber. The apparatus further comprises a plurality of optical filters aligned in respective optical paths of the optical path plurality comprising at least a first optical filter with light absorption by lactate and water and a second optical filter with light absorption to water alone. A logic determines lactate concentration based on a ratio of intensities detected at a first detector in an optical path intersected by the first optical filter and detected at a second detector in an optical path intersected by the second optical filter.

    摘要翻译： 一种乳酸盐浓度测量装置，包括：壳体，其包围被构造成用于保持体液样本的样本室，以及测量光学光学器件，其产生光并沿着样本室中的多个光路监测光强度。 该装置还包括多个光学滤光器，该多个光学滤光器在光路的各个光路中排列成多个，至少包括具有乳酸和水的光吸收的第一滤光器以及仅对水单独吸收光的第二滤光器。 逻辑根据在与第一滤光器相交的光路中的第一检测器检测到的强度的比值确定乳酸浓度，并且在与第二滤光器相交的光路中的第二检测器处检测。

    Analyte Concentration Measurement Device
    5.
    发明申请
    Analyte Concentration Measurement Device 审中-公开
    分析物浓度测定装置

    公开(公告)号：US20090018416A1

    公开(公告)日：2009-01-15

    申请号：US11777940

    申请日：2007-07-13

    申请人： Stephen D. Walker ,  Devon J. Dallmann ,  Charles W. Henry ,  Peter E. Nelson ,  R. Dale Zellers ,  John E. Repine

    发明人： Stephen D. Walker ,  Devon J. Dallmann ,  Charles W. Henry ,  Peter E. Nelson ,  R. Dale Zellers ,  John E. Repine

    IPC分类号： A61B5/00

    CPC分类号： G01N21/314 ,  A61B5/14532 ,  G01N21/35

    摘要： A method for measuring concentration of an analyte in body fluid comprises acquiring a body fluid sample, emitting light into the body fluid sample, and detecting emitted light intensity on a plurality of optical paths through the body fluid sample. A plurality of optical filters are arranged in respective optical paths of the optical path plurality comprising at least a first optical filter with light absorption by an analyte and water and a second optical filter with light absorption to water alone. Light intensity passed through the first optical filter and passed through the second optical filter is measured and analyte concentration is determined based on a ratio of intensities detected at a detector in an optical path intersected by the first optical filter and detected at a detector in an optical path intersected by the second optical filter.

    摘要翻译： 用于测量体液中分析物浓度的方法包括获取体液样品，将光发射到体液样品中，以及检测通过体液样品的多条光路上的发射光强度。 多个光学滤光器被布置在包括至少一个具有被分析物和水的光吸收的第一滤光器的光路的多个光路中，以及仅对水单独吸收光的第二滤光器。 测量通过第一滤光器并通过第二滤光器的光强度，并且基于在由第一滤光器相交的光路中的检测器处检测到的强度的比率确定分析物浓度，并在光学检测器中检测 路径与第二光学滤波器相交。

    VCSEL Tissue Spectrometer
    6.
    发明申请
    VCSEL Tissue Spectrometer 审中-公开
    VCSEL组织光谱仪

    公开(公告)号：US20080004513A1

    公开(公告)日：2008-01-03

    申请号：US11428217

    申请日：2006-06-30

    申请人： Stephen D. Walker ,  Peter E. Nelson ,  R. Dale Zellers ,  Charles W. Henry ,  John E. Repine

    发明人： Stephen D. Walker ,  Peter E. Nelson ,  R. Dale Zellers ,  Charles W. Henry ,  John E. Repine

    IPC分类号： A61B5/00

    CPC分类号： A61B5/14532 ,  A61B5/1455 ,  A61B5/412 ,  A61B2562/0233 ,  A61B2562/043

    摘要： In a tissue sensor, a plurality of emitters are configured to emit narrowband light into biological tissue at a plurality of selected wavelengths including one or more wavelengths indicative of a profile for one or more selected analytes and a reference wavelength at which absorbance for the selected analyte is negligible. The sensor further comprises a photo detector configured to detect light at wavelengths that emerge from the biological tissue.

    摘要翻译： 在组织传感器中，多个发射器被配置为以多个选定的波长将窄带光发射到生物组织中，所述多个选定波长包括一个或多个波长，其指示一个或多个所选分析物的分布，以及所选分析物的吸光度 是微不足道的 传感器还包括被配置为检测从生物组织出现的波长处的光的光检测器。

    Compositions and methods for treating lung disorders
    8.
    发明授权
    Compositions and methods for treating lung disorders 有权
    用于治疗肺部疾病的组合物和方法

    公开(公告)号：US09383348B2

    公开(公告)日：2016-07-05

    申请号：US13000603

    申请日：2009-06-22

    申请人： John E. Repine

    发明人： John E. Repine

    IPC分类号： A61K8/00 ,  A61K31/4178 ,  A61K31/00 ,  A61K31/195 ,  G01N33/50 ,  A61K31/385 ,  A61K31/4164

    CPC分类号： G01N33/5005 ,  A61K31/195 ,  A61K31/385 ,  A61K31/4164 ,  G01N2500/10 ,  G01N2800/12 ,  G01N2800/125

    摘要： The present invention relates to methods of treating subjects with alveolar capillary membrane injury or methods of preventing alveolar capillary membrane injury in subjects, with the methods comprising administering to the subjects a therapeutically effective amount of ergothioneine and a pharmaceutically acceptable carrier. The invention also relates to methods of screening candidate compounds for their ability to mitigate the effects of alveolar capillary membrane injury.

    摘要翻译： 本发明涉及用肺泡毛细血管膜损伤治疗受试者的方法或预防受试者中肺泡毛细血管膜损伤的方法，其方法包括向受试者施用治疗有效量的麦角硫素和药学上可接受的载体。 本发明还涉及筛选候选化合物以减轻肺泡毛细血管膜损伤的作用的能力的方法。

    Serum ferritin as a predictor of the acute respiratory distress syndrome
    10.
    发明授权
    Serum ferritin as a predictor of the acute respiratory distress syndrome 失效
    血清铁蛋白作为急性呼吸窘迫综合征的预测因子

    公开(公告)号：US5679532A

    公开(公告)日：1997-10-21

    申请号：US571588

    申请日：1995-12-13

    申请人： John E. Repine

    发明人： John E. Repine

    IPC分类号： G01N33/68 ,  G01N33/53 ,  C12Q1/30 ,  C12Q1/32 ,  G01N33/573

    CPC分类号： G01N33/68 ,  Y10S435/975

    摘要： The invention relates to the discovery that serum ferritin concentrations are elevated in patients at risk for the development of Acute Respiratory Distress Syndrome (ARDS) and who subsequently develop ARDS, as compared to at-risk patients who do not subsequently develop ARDS. Thus, the invention includes a method for determining ARDS development potential in an at-risk patient comprising the steps of determining the patient's serum concentration of ferritin and determining ARDS development potential from said serum concentration of ferritin.

    摘要翻译： 本发明涉及到发现急性呼吸窘迫综合征（ARDS）并随后发展ARDS风险的患者的血清铁蛋白浓度升高，与不随后发展ARDS的风险患者相比，血清铁蛋白浓度升高。 因此，本发明包括一种在风险患者中测定ARDS发展潜力的方法，包括以下步骤：从所述血清铁蛋白浓度确定患者的铁蛋白血清浓度并确定ARDS发展潜力。