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公开(公告)号：USD277891S
公开(公告)日：1985-03-05
申请号：US416804
申请日：1982-09-13
Applicant: Kenneth F. Uffenheimer , Dario Svenjak , Herman G. Diebler , William J. C. McCandless , Rand E. Herron , Stephen Saros
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公开(公告)号：US4669756A
公开(公告)日：1987-06-02
申请号：US735528
申请日：1985-05-20
Applicant: Michael M. Cassaday , Leon Castellani , Stephen Saros
Inventor： Michael M. Cassaday , Leon Castellani , Stephen Saros
CPC classification number: F16L47/00
Abstract: New and improved connector is provided for the zero dead volume connection of separate, like diameter flexible tubing lengths by direct tubing length end abutment and connection under controlled conditions. The connector is particularly adapted for use with tubing lengths of fluorocarbon or like materials in contemporary biomedical sample liquid analysis systems which utilize an immiscible isolation liquid or "oil" to minimize sample liquid carryover and maximize the accuracy of sample liquid analysis results.
Abstract translation: 提供了新的和改进的连接器，用于在受控条件下通过直接管道长度端邻接和连接的单独的类似直径的柔性管段的零死体积连接。 连接器特别适用于当代生物医学样品液体分析系统中的氟化碳或类似材料的管道长度，其利用不混溶的隔离液体或“油”以最小化样品液体携带并最大化样品液体分析结果的准确性。
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公开(公告)号：US4853336A
公开(公告)日：1989-08-01
申请号：US10236
申请日：1987-02-02
Applicant: Stephen Saros , John L. Smith , Michael M. Cassaday , Rand E. Herron , Milton H. Pelavin
Inventor： Stephen Saros , John L. Smith , Michael M. Cassaday , Rand E. Herron , Milton H. Pelavin
CPC classification number: G01N35/08 , G01N2035/0415 , G01N2035/0443 , G01N35/025 , Y10T436/117497 , Y10T436/118339
Abstract: A continuous flow system is disclosed in which successive liquid segments are established containing different related components of a fluid package, such as an analysis mixture, separated by at least one immiscible segment, passed along a first section of a conduit, combined in a second section of the conduit and mixed while passing along a third section of the conduit, so as to provide a completely mixed segment. This system permits the delayed on-line mixing of different components of an analysis mixture, such as samples with reagents or diluents, as well as mixing and interaction of such components in a single conduit.
Abstract translation: 公开了一种连续流动系统，其中建立了连续的液体段，其包含流体包装（例如分析混合物）的不同相关组分，分离混合物由至少一个不混溶段分隔，沿着导管的第一部分通过，在第二部分 并在通过导管的第三部分时混合，以便提供完全混合的部分。 该系统允许分析混合物的不同组分（例如具有试剂或稀释剂的样品）的延迟在线混合，以及这些组分在单个导管中的混合和相互作用。
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公开(公告)号：US4517302A
公开(公告)日：1985-05-14
申请号：US441720
申请日：1982-11-15
Applicant: Stephen Saros
Inventor： Stephen Saros
CPC classification number: G01N35/1097 , G01N35/08 , G01N33/04 , Y10T436/118339 , Y10T436/2575
Abstract: Continuous flow metering apparatus and methods using liquid position sensors in conjunction with flow-stopping valves control (meter) fluid, e.g. sample/reagent/air, aspiration into a single conduit, such as in a continuous flow system. Air or other gas separates selected ones of the liquid segments. The volume of the aspirated segment is established by sensing a flow parameter of the segmented stream of a selected one of the sensors. A pulse is generated by the sensors (detectors), for example due to the change of light intensity at a liquidair interface traversing the conduit. The signal pulse from a sensor causes the actuation of a selected one of the valves and stops aspiration (flow) of the liquid by traversing the flow path in the conduit through an air segment. The valve cuts through air only. Therefore, the body of the valve does not contact reagent or sample liquid by this action and the risk of carryover contamination is avoided. With the aspiration cycle completed, the input end of the conduit, e.g. an aspirating probe, can consequently be immersed in different media and the cycle repeated.
Abstract translation: 连续流量计量装置和方法使用液体位置传感器结合流量停止阀来控制（流量）流体，例如流量。 样品/试剂/空气，抽吸到单个导管中，例如在连续流动系统中。 空气或其他气体分离选定的液体段。 抽吸段的体积通过感测所选传感器的分段流的流量参数而建立。 传感器（检测器）产生脉冲，例如由于穿过导管的液体空气界面处的光强度的变化。 来自传感器的信号脉冲导致所选择的一个阀的致动，并且通过穿过空气段的管道中的流动路径停止液体的抽吸（流动）。 阀只切断空气。 因此，阀体不接触试剂或样品液体，避免了携带污染的风险。 在抽吸循环完成之后，导管的输入端，例如， 一个吸气探针，因此可以浸入不同的介质和循环重复。
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