公开(公告)号：US08815909B2

公开(公告)日：2014-08-26

申请号：US13549767

申请日：2012-07-16

申请人： William R. Ewing ,  Yeheng Zhu ,  Chongqing Sun ,  Yanting Huang ,  Maheswaran Sivasamban Karatholuvhu ,  Scott A. Bolton ,  Laxman Pasunoori ,  Sunil Kumar Mandal ,  Philip M. Sher

发明人： William R. Ewing ,  Yeheng Zhu ,  Chongqing Sun ,  Yanting Huang ,  Maheswaran Sivasamban Karatholuvhu ,  Scott A. Bolton ,  Laxman Pasunoori ,  Sunil Kumar Mandal ,  Philip M. Sher

IPC分类号： A01N43/40 ,  A61K31/445 ,  A01N43/42 ,  A61K31/44 ,  A01N57/00 ,  A61K31/43

CPC分类号： A61K31/506 ,  A61K31/437 ,  A61K31/439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/498 ,  A61K31/501 ,  A61K45/06 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07D417/12 ,  C07D451/02 ,  C07D453/06 ,  C07D471/04 ,  C07D471/08

摘要： The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are agonists, partial agonists and modulators of the NPY Y4 receptor and may be used for the treatment and prophylaxis of various diseases and conditions.

公开(公告)号：US20130184284A1

公开(公告)日：2013-07-18

申请号：US13549767

申请日：2012-07-16

申请人： William R. Ewing ,  Yeheng Zhu ,  Chongqing Sun ,  Yanting Huang ,  Maheswaran Sivasamban Karatholuvhu ,  Scott A. Bolton ,  Laxman Pasunoori ,  Sunil Kumar Mandal ,  Philip M. Sher

发明人： William R. Ewing ,  Yeheng Zhu ,  Chongqing Sun ,  Yanting Huang ,  Maheswaran Sivasamban Karatholuvhu ,  Scott A. Bolton ,  Laxman Pasunoori ,  Sunil Kumar Mandal ,  Philip M. Sher

IPC分类号： A61K31/506 ,  A61K31/454 ,  A61K31/439 ,  C07D401/12 ,  A61K31/4545 ,  A61K45/06 ,  C07D401/14 ,  A61K31/498 ,  A61K31/501 ,  C07D471/04 ,  A61K31/437 ,  C07D413/12 ,  A61K31/497

CPC分类号： A61K31/506 ,  A61K31/437 ,  A61K31/439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/498 ,  A61K31/501 ,  A61K45/06 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07D417/12 ,  C07D451/02 ,  C07D453/06 ,  C07D471/04 ,  C07D471/08

摘要： The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are agonists, partial agonists and modulators of the NPY Y4 receptor and may be used for the treatment and prophylaxis of various diseases and conditions.