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公开(公告)号：US08343718B2
公开(公告)日：2013-01-01
申请号：US12754908
申请日：2010-04-06
申请人： Sylvie Van Der Werf , Nicolas Escriou , Bernadette Crescenzo-Chaigne , Jean-Claude Manuguerra , Frederik Kunst , Benoît Callendret , Jean-Michel Betton , Valérie Lorin , Sylvie Gerbaud , Ana Maria Burguiere , Saliha Azebi , Pierre Charneau , Frédéric Tangy , Chantal Combredet , Jean-François Delagneau , Monique Martin
发明人： Sylvie Van Der Werf , Nicolas Escriou , Bernadette Crescenzo-Chaigne , Jean-Claude Manuguerra , Frederik Kunst , Benoît Callendret , Jean-Michel Betton , Valérie Lorin , Sylvie Gerbaud , Ana Maria Burguiere , Saliha Azebi , Pierre Charneau , Frédéric Tangy , Chantal Combredet , Jean-François Delagneau , Monique Martin
IPC分类号： C12Q1/70 , G01N33/53 , G01N33/542 , G01N33/00
CPC分类号： C07K14/005 , C12N7/00 , C12N2770/20022 , G01N33/569
摘要： The invention relates to a novel strain of severe acute respiratory syndrome (SARS)-associated coronavirus, resulting from a sample collected in Hanoi (Vietnam), reference number 031589, nucleic acid molecules originating from the genome of same, proteins and peptides coded by said nucleic acid molecules and, more specifically, protein N and the applications thereof, for example, as diagnostic reagents and/or as a vaccine.
摘要翻译： 本发明涉及由河内（越南）收集的样品，参考号031589，源自其基因组的核酸分子产生的重症急性呼吸综合征（SARS）相关冠状病毒的新型菌株，由所述 核酸分子，更具体地，蛋白N及其应用，例如作为诊断试剂和/或疫苗。
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2.发明申请USE OF PROTEINS AND PEPTIDES ENCODED BY THE GENOME OF A NOVEL SARS-ASSOCIATED CORONAVIRUS STRAIN 审中-公开使用由新型SARS相关的金黄色葡萄球菌菌株编码的蛋白质和肽公开(公告)号：US20120082693A1
公开(公告)日：2012-04-05
申请号：US13187011
申请日：2011-07-20
申请人： Sylvie VAN DER WERF , Nicolas Escriou , Bernadette Crescenzo-Chaigne , Jean-Claude Manuguerra , Frederik Kunst , Benoît Callendret , Jean-Michel Betton , Valérie Lorin , Sylvie Gerbaud , Ana Maria Burguiere , Saliha Azebi , Pierre Charneau , Frédéric Tangy , Chantal Combredet , Jean-François Delagneau , Monique Martin
发明人： Sylvie VAN DER WERF , Nicolas Escriou , Bernadette Crescenzo-Chaigne , Jean-Claude Manuguerra , Frederik Kunst , Benoît Callendret , Jean-Michel Betton , Valérie Lorin , Sylvie Gerbaud , Ana Maria Burguiere , Saliha Azebi , Pierre Charneau , Frédéric Tangy , Chantal Combredet , Jean-François Delagneau , Monique Martin
IPC分类号： A61K39/215 , C12N15/50 , C12N15/63 , C12N1/21 , C12N7/01 , A61P31/14 , C12N5/10 , C07K16/10 , C12Q1/70 , C07K19/00 , A61P37/04 , C07K14/165 , C12P21/02
CPC分类号： C07K14/005 , C12N7/00 , C12N2770/20022 , G01N33/569
摘要： The invention relates to the use of proteins and peptides coded by the genome of the isolated or purified strain of severe acute respiratory syndrome (SARS)-associated coronavirus, resulting from sample reference number 031589 and, in particular, to the use of protein S and the derivative antibodies thereof as diagnostic reagents and as a vaccine.
摘要翻译： 本发明涉及由分离或纯化的重症急性呼吸综合征（SARS）相关冠状病毒株的基因组编码的蛋白质和肽的用途，由样品参考号031589得到，特别是使用蛋白S和 其衍生抗体作为诊断试剂和疫苗。
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公开(公告)号：US20120045469A1
公开(公告)日：2012-02-23
申请号：US13132364
申请日：2009-12-01
申请人： Benoit Baras , Benoit Callendret , Nicolas Escriou , Valerie Lorin , Philippe Marianneau , Sylvie Van Der Werf , Martine Anne Cecile Wettendorff
发明人： Benoit Baras , Benoit Callendret , Nicolas Escriou , Valerie Lorin , Philippe Marianneau , Sylvie Van Der Werf , Martine Anne Cecile Wettendorff
CPC分类号： C07K14/005 , A61K39/12 , A61K39/215 , A61K39/39 , A61K2039/5252 , A61K2039/55505 , A61K2039/55566 , C07K16/10 , C07K2317/76 , C12N2770/20022 , C12N2770/20034
摘要： The present invention provides an immunogenic composition comprising: an immunogenic SARS coronavirus S (spike) polypeptide, or a fragment or variant thereof; and an adjuvant comprising an oil-in-water emulsion.
摘要翻译： 本发明提供免疫原性组合物，其包含：免疫原性SARS冠状病毒S（穗状）多肽或其片段或变体; 和包含水包油乳剂的佐剂。
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公开(公告)号：US20070134270A1
公开(公告)日：2007-06-14
申请号：US10547155
申请日：2004-02-27
IPC分类号： A61K39/145 , C12Q1/70 , C07H21/04 , C12N5/10 , C07K14/11
CPC分类号： C12N9/1247 , A61K39/00 , A61K2039/525
摘要： The invention relates to a novel polynucleotide exhibiting a promoting transcription activity, polynucleotide-containing vectors and to the use thereof for the transcription of interesting sequences such as the production of non-cap RNA virus. Said invention also relates to host cells preferably of avian origin, containing a polynucleotide or the inventive vector.
摘要翻译： 本发明涉及一种表现出促进转录活性的新型多核苷酸，含多核苷酸的载体及其用于转录感兴趣序列（例如产生非帽RNA病毒）的用途。 所述发明还涉及含有多核苷酸或本发明载体的优选鸟类来源的宿主细胞。
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公开(公告)号：US20070128224A1
公开(公告)日：2007-06-07
申请号：US10581356
申请日：2004-12-02
申请人： Sylvie Van Der Werf , Nicolas Escriou , Bernadette Crescenzo-Chaigne , Jean-Claude Manuguerra , Frederick Kunst , Benoit Callendret , Jean-Michel Betton , Valerie Lorin , Sylvie Gerbaud , Ana Burguiere , Saliha Azebi , Pierre Charneau , Frederic Tangy , Chantal Combredet , Jean-Francois Delagneau , Monique Martin
发明人： Sylvie Van Der Werf , Nicolas Escriou , Bernadette Crescenzo-Chaigne , Jean-Claude Manuguerra , Frederick Kunst , Benoit Callendret , Jean-Michel Betton , Valerie Lorin , Sylvie Gerbaud , Ana Burguiere , Saliha Azebi , Pierre Charneau , Frederic Tangy , Chantal Combredet , Jean-Francois Delagneau , Monique Martin
IPC分类号： A61K39/215 , C12Q1/70 , C07H21/04 , C07K14/165 , C07K16/10 , C12N5/06
CPC分类号： C07K14/005 , C12N7/00 , C12N2770/20022 , G01N33/569
摘要： The invention relates to a novel strain of severe acute respiratory syndrome (SARS)-associated coronavirus, resulting from a sample collected in Hanoi (Vietnam), reference number 031589, nucleic acid molecules originating from the genome of same, proteins and peptides coded by said nucleic acid molecules and, more specifically, protein N and the applications thereof, for example, as diagnostic reagents and/or as a vaccine.
摘要翻译： 本发明涉及由河内（越南）收集的样品，参考号031589，源自其基因组的核酸分子产生的重症急性呼吸综合征（SARS）相关冠状病毒的新型菌株，由所述 核酸分子，更具体地，蛋白N及其应用，例如作为诊断试剂和/或疫苗。
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公开(公告)号：US07736850B2
公开(公告)日：2010-06-15
申请号：US10581356
申请日：2004-12-02
申请人： Sylvie Van Der Werf , Nicolas Escriou , Bernadette Crescenzo-Chaigne , Jean-Claude Manuguerra , Frederick Kunst , Benoît Callendret , Jean-Michel Betton , Valérie Lorin , Sylvie Gerbaud , Ana Maria Burguiere , Saliha Azebi , Pierre Charneau , Frédéric Tangy , Chantal Combredet , Jean-François Delagneau , Monique Martin
发明人： Sylvie Van Der Werf , Nicolas Escriou , Bernadette Crescenzo-Chaigne , Jean-Claude Manuguerra , Frederick Kunst , Benoît Callendret , Jean-Michel Betton , Valérie Lorin , Sylvie Gerbaud , Ana Maria Burguiere , Saliha Azebi , Pierre Charneau , Frédéric Tangy , Chantal Combredet , Jean-François Delagneau , Monique Martin
IPC分类号： C12Q1/68
CPC分类号： C07K14/005 , C12N7/00 , C12N2770/20022 , G01N33/569
摘要： The invention relates to a novel strain of severe acute respiratory syndrome (SARS)-associated coronavirus, resulting from a sample collected in Hanoi (Vietnam), reference number 031589, nucleic acid molecules originating from the genome of same, proteins and peptides coded by said nucleic acid molecules and, more specifically, protein N and the applications thereof, for example, as diagnostic reagents and/or as a vaccine.
摘要翻译： 本发明涉及由河内（越南）收集的样品，参考号031589，源自其基因组的核酸分子产生的重症急性呼吸综合征（SARS）相关冠状病毒的新型菌株，由所述 核酸分子，更具体地，蛋白N及其应用，例如作为诊断试剂和/或疫苗。
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7.发明授权Peptides comprising an immunogenic site of poliovirus and DNAs containing nucleotide sequences coding for these peptides 失效包含脊髓灰质炎病毒免疫原性位点的肽和含有编码这些肽的核苷酸序列的DNA
公开(公告)号：US5198536A
公开(公告)日：1993-03-30
申请号：US730066
申请日：1991-07-15
申请人： Marc Girard , Sylvie Van Der Werf
发明人： Marc Girard , Sylvie Van Der Werf
IPC分类号： A61K39/00 , C07K14/105 , C12Q1/70
CPC分类号： C07K14/005 , C12Q1/701 , A61K39/00 , C12N2770/32622 , C12N2770/32634
摘要： The invention relates to a DNA fragment containing at the most 315 pairs of nucleotides coding for a peptide which can be recognized by antibodies acting both against the "C" and "D" particles of the same poliovirus and against the VP-1 structural polypeptide of the capsid of this poliovirus. This peptide contains in particular the following sequence:Asp Asn Pro Ala Ser thr Thr Asn Lys Asp Lys Leu.
摘要翻译： 本发明涉及含有编码肽的最多315对核苷酸的DNA片段，所述肽可以被同时针对相同脊髓灰质炎病毒的“C”和“D”颗粒起作用的抗体所识别，并且对抗VP-1结构多肽 这种脊髓灰质炎病毒的衣壳。 该肽特别包含以下序列：Asp Asn Pro Ala Ser thr Thr Asn Lys Asp Lys Leu。
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8.发明授权Peptides comprising an immunogenic site of poliovirus and DNAs containing nucleotide sequences coding for these peptides 失效包含含有这些肽的核糖核酸序列编码的杆状病毒和DNA的免疫原性的肽
公开(公告)号：US5061623A
公开(公告)日：1991-10-29
申请号：US538668
申请日：1990-06-15
申请人： Marc Girard , Sylvie Van Der Werf
发明人： Marc Girard , Sylvie Van Der Werf
IPC分类号： C12N15/09 , A61K39/00 , A61K39/13 , A61P31/12 , C07K7/08 , C07K14/00 , C07K14/105 , C07K14/18 , C07K17/00 , C07K19/00 , C12N1/21 , C12P21/02 , C12Q1/70 , C12R1/19
CPC分类号： C07K14/005 , C12Q1/701 , A61K39/00 , C12N2770/32622 , C12N2770/32634
摘要： The invention relates to a DNA fragment containing at the most 315 pairs of nucleotides coding for a peptide which can be recognized by antibodies acting both against the "C" and "D" particles of the same poliovirus and against the VP-1 structural polypeptide of the capsid of this poliovirus. This peptide contains in particular the following sequence: Asp Asn Pro Ala Ser Thr Asn Lys Asp Lys Leu.
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公开(公告)号：US07935807B2
公开(公告)日：2011-05-03
申请号：US10547155
申请日：2004-02-27
CPC分类号： C12N9/1247 , A61K39/00 , A61K2039/525
摘要： The invention relates to a novel polynucleotide exhibiting a promoting transcription activity, polynucleotide-containing vectors and to the use thereof for the transcription of interesting sequences such as the production of non-cap RNA virus. Said invention also relates to host cells preferably of avian origin, containing a polynucleotide or the inventive vector.
摘要翻译： 本发明涉及一种表现出促进转录活性的新型多核苷酸，含多核苷酸的载体及其用于转录感兴趣序列（例如产生非帽RNA病毒）的用途。 所述发明还涉及含有多核苷酸或本发明载体的优选禽类来源的宿主细胞。
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10.发明授权RECOMBINANT SEGMENTED NEGATIVE STRAND VIRUS CONTAINING BICISTRONIC VRNA SEGMENT WITH A DUPLICATION OF ITS 3′ NONCODING FLANKING SEQUENCE, AND VACCINES AND THERAPEUTIC COMPOSITIONS CONTAINING THE SAME 有权含有其3'非编码顺序的复合体分离的含有BICISTRONIC VRNA区段的重组分离的阴性病毒病毒，以及含有其的疫苗和治疗组合物公开(公告)号：US06723559B2
公开(公告)日：2004-04-20
申请号：US10123170
申请日：2002-04-17
IPC分类号： C12N1574
CPC分类号： C07K14/005 , A61K2039/5256 , C12N15/86 , C12N2730/10122 , C12N2760/16122 , C12N2840/20
摘要： The present invention relates to recombinant negative strand RNA molecules which may be used to express heterologous proteins in animal cells and/or to construct recombinant viruses able to express heterologous proteins during their multiplication in host animal cells.
摘要翻译： 本发明涉及可用于在动物细胞中表达异源蛋白质的重组负链RNA分子和/或构建能够在宿主动物细胞繁殖期间表达异源蛋白质的重组病毒。
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