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1.发明申请公开(公告)号：US20200297783A1
公开(公告)日：2020-09-24
申请号：US16895460
申请日：2020-06-08
申请人： INSERM (INSTITUT NATION DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , CENTRE HOSPITALIER UNIVERSITAIRE DE ROUEN , UNIVERSITÉ DE ROUEN , TARGEDYS
发明人： Serguei FETISSOV , Pierre DECHELOTTE , Jonathan BRETON , Gregory LAMBERT , Naouel TENNOUNE , Romain LEGRAND
IPC分类号： A61K35/741 , A61K35/74 , A61K38/16 , A23L33/00 , A23L33/135 , A61K9/00 , A61P3/04
摘要： The present invention relates to pharmaceutical and food compositions for inducing satiation and prolonging satiety in subjects in need thereof. In particular, the present invention relates to a method of inducing satiation in a subject in need thereof comprising administering to the subject an effective amount of a ClpB protein or an effective amount of a bacterium that expresses the ClpB protein.
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公开(公告)号：US20210008125A1
公开(公告)日：2021-01-14
申请号：US16902732
申请日：2020-06-16
申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) , Centre Hospitalier Universitaire de Rouen , Universite de Rouen , TARGEDYS
发明人： Serguei Fetissov , Emmanuelle De , Naouel Tennoune , Jonathan Breton , Philippe Chan-Tchi-Song , Pierre Dechelotte , Romain Legrand , Gregory Lambert
IPC分类号： A61K35/741 , A61P3/04 , A61P3/10 , A61P3/06 , A23L33/135
摘要： The present invention relates to method of preventing, treating or attenuating obesity-related manifestations in a human or non-human mammal subject in need thereof, said method comprising orally administering to the subject a composition comprising an effective amount Hafnia alvei probiotics; wherein said obesity-related parameters are selected from the group of hyperphagia, increased fat mass on lean mass ratio, increased waist circumference, postprandial hyperglycemia, fasting hyperglycemia and hypercholesterolemia.
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公开(公告)号：US10729770B2
公开(公告)日：2020-08-04
申请号：US16032604
申请日：2018-07-11
申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) , Centre Hospitalier Universitaire de Rouen , Universite de Rouen , TARGEDYS
发明人： Serguei Fetissov , Emmanuelle De , Naouel Tennoune , Jonathan Breton , Philippe Chan-Tchi-Song , Pierre Dechelotte , Romain Legrand , Gregory Lambert
摘要： The present invention relates to ClpB expressing bacteria and their impact on obesity. The present invention relates to bacterial ClpB protein and ClpB expressing bacteria and their impact on eating disorders. The invention further relates to compositions comprising antibiotic directed against at least one ClpB expressing bacterium as well as probiotics not expressing ClpB protein and their use in the treatment or prevention of eating disorders. The invention also relates to diagnostic tools for determining whether a subject is likely to respond to a method of treating eating disorders and to methods of immunization against eating disorders.
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公开(公告)号：US10682389B2
公开(公告)日：2020-06-16
申请号：US15579459
申请日：2016-04-05
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE HOSPITALIER UNIVERSITAIRE DE ROUEN , UNIVERSITÉ DE ROUEN , TARGEDYS
IPC分类号： A61K39/00 , A61K39/38 , A61K39/02 , A61K39/385 , A61K39/08 , A61K45/00 , A61K38/16 , A61K35/74 , A23L33/00 , A23L33/135 , A61P3/04 , A61K35/741
摘要： The present invention relates to pharmaceutical and food compositions for inducing satiation and prolonging satiety in subjects in need thereof. In particular, the present invention relates to a method of inducing satiation in a subject in need thereof comprising administering to the subject an effective amount of a ClpB protein or an effective amount of a bacterium that expresses the ClpB protein.
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公开(公告)号：US20220000941A1
公开(公告)日：2022-01-06
申请号：US17289902
申请日：2019-11-28
申请人： TARGEDYS
发明人： Clémentine PICOLO , Grégory LAMBERT
IPC分类号： A61K35/741 , A61K33/30 , A61K33/24 , A61K9/00
摘要： A pharmaceutical or nutraceutical composition, including a Hafnia alvei strain probiotic composition; the strain expressing the ClpB protein; in association with zinc bisglycinate and/or chrome picolinate. Additionally, oral dosage forms of the pharmaceutical or nutraceutical composition including the Hafnia alvei strain probiotic composition in association with zinc bisglycinate and/or chrome picolinate.
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公开(公告)号：US20210401020A1
公开(公告)日：2021-12-30
申请号：US17290385
申请日：2019-11-28
申请人： TARGEDYS , CENTRE HOSPITALIER UNIVERSITAIRE DE ROUEN , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITÉ DE ROUEN
IPC分类号： A23L33/135 , A23L33/00 , A61K35/741 , A61K9/48
摘要： A composition essentially made of a Hafnia alvei probiotic strain expressing the ClpB protein; wherein the ClpB protein is in an amount of at least 0.7% (w/w) in weight relative to the total weight of the composition; and the ratio of the total number of Hafnia alvei Colony Forming Units to the total Hafnia alvei cell number ranges from 10−4 to 0.8. Also, oral dosage forms, namely gastro-resistant capsules including the composition of essentially made of a Hafnia alvei probiotic strain expressing the ClpB protein.
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公开(公告)号：US10888592B2
公开(公告)日：2021-01-12
申请号：US16091678
申请日：2017-04-05
申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , CENTRE HOSPITALIER UNIVERSITAIRE DE ROUEN , TARGEDYS , UNIVERSITE DE ROUEN
发明人： Serguei Fetissov , Pierre Dechelotte , Jonathan Breton , Gregory Lambert , Romain Legrand , Nicolas Lucas
IPC分类号： A61K35/741 , A61K35/74 , A61K38/16 , A23L33/00 , A23L33/135 , A61K9/00 , A61P3/04
摘要： The present invention relates to pharmaceutical and food compositions for inducing satiation and prolonging satiety in subjects in need thereof. In particular, the present invention relates to a method of inducing satiation in a subject in need thereof comprising administering to the subject an effective amount of Hafnia alvei.
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公开(公告)号：US11319352B2
公开(公告)日：2022-05-03
申请号：US16500494
申请日：2018-04-03
申请人： TARGEDYS , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITÉ DE ROUEN
IPC分类号： C07K14/415 , A23L33/12 , A23L33/16 , A61K38/00
摘要： Methods of treating inflammation, in particular obesity, inducing satiation, prolonging satiety, and stimulating weight loss in a subject in need thereof, including the administration of a Brassicaceae protein extract. The Brassicaceae protein extract may be administered in the form of a dietary supplement or a food composition, either of which may include at least one additional ingredient.
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9.发明申请公开(公告)号：US20180153959A1
公开(公告)日：2018-06-07
申请号：US15579459
申请日：2016-04-05
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE HOSPITALIER UNIVERSITAIRE DE ROUEN , UNIVERSITÉ DE ROUEN , TARGEDYS
IPC分类号： A61K38/16 , A61K35/741 , A23L33/135 , A23L33/00 , A61P3/04
CPC分类号： A61K38/164 , A23L33/135 , A23L33/30 , A23V2002/00 , A23V2200/3204 , A61K35/74 , A61K35/741 , A61P3/04
摘要： The present invention relates to pharmaceutical and food compositions for inducing satiation and prolonging satiety in subjects in need thereof. In particular, the present invention relates to a method of inducing satiation in a subject in need thereof comprising administering to the subject an effective amount of a ClpB protein or an effective amount of a bacterium that expresses the ClpB protein.
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10.发明申请公开(公告)号：US20170252399A1
公开(公告)日：2017-09-07
申请号：US15516040
申请日：2015-06-05
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , CENTRE HOSPITALIER UNIVERSITAIRE DE ROUEN , UNIVERSITÉ DE ROUEN , TARGEDYS
IPC分类号： A61K38/16 , A23L33/00 , A23L33/135 , A61K35/741 , A61K9/00
CPC分类号： A61K35/741 , A23L33/135 , A23L33/30 , A23V2002/00 , A23V2200/3202 , A23V2200/3204 , A23V2200/332 , A61K9/0095 , A61K35/74 , A61K38/164 , A61P3/04
摘要： The present invention relates to pharmaceutical and food compositions for inducing satiation and prolonging satiety in subjects in need thereof. In particular, the present invention relates to a method of inducing satiation in a subject in need thereof comprising administering to the subject an effective amount of a ClpB protein or an effective amount of a bacterium that expresses the ClpB protein.
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