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    Intelligent continuous manufacturing method via liquid cooling of dripping pills
    4.
    发明授权
    Intelligent continuous manufacturing method via liquid cooling of dripping pills 有权

    公开(公告)号：US10813840B2

    公开(公告)日：2020-10-27

    申请号：US15760367

    申请日：2016-09-14

    申请人： TASLY PHARMACEUTICAL GROUP CO., LTD.

    发明人： Kaijing Yan ,  Xiaobing Sun ,  Changsheng Rong ,  Xuefei Cai ,  Liang Wang

    IPC分类号： A61J3/06 ,  A61K9/20

    摘要： An intelligent continuous manufacturing method via liquid cooling of dripping pills comprises the following steps: (1) feeding: weighing and transferring multiple materials respectively; (2) material combining: performing staged heating on the materials transferred in step (1), and mixing the same to obtain a material mixture, wherein an RSD of an effective ingredient in the material mixture ≤5%; (3) homogenizing: pressurizing the material mixture obtained in step (2), and increasing the temperature, so as to obtain a homogenized material having the RSD of the effective ingredient in the material mixture ≤5%; (4) dripping: performing vibration dripping on the homogenized material obtained in step (3) to obtain dripping pills, delivering the dripping pills into a cooling liquid to be cooled and then transferred; and (5) de-oiling: removing the cooling liquid on surfaces of the dripping pills obtained in step (4) via tilting centrifugation. The manufacturing method not only shortens the manufacturing process, but also ensures the dripping pill product to be more stable and homogeneous. In addition, high-speed centrifugation is used to reasonably de-oil the dripping pills to prevent contamination of the dripping pills and improve the circulation utilization rate of the cooling liquid.

    Air-cooling micro drop pill capsule production line
    6.
    发明授权
    Air-cooling micro drop pill capsule production line 有权

    公开(公告)号：US10111811B2

    公开(公告)日：2018-10-30

    申请号：US14903789

    申请日：2014-07-11

    申请人： TASLY PHARMACEUTICAL GROUP CO., LTD.

    发明人： Xijun Yan ,  Xiaobing Sun ,  Yongfeng Zheng ,  Lijun Fan ,  Yan Fu

    IPC分类号： A61J3/00 ,  B01J2/18 ,  B01J2/04 ,  B01J2/02 ,  A61J3/06

    摘要： An air-cooling micro drop pill capsule production line comprises a drop pill system, an air-cooling circulation system and a control system. The drop pill system comprises a molten material tank and a dripper. A vibration apparatus is arranged between the molten material tank and the dripper, and drives the dripper to vibrate up and down. A vibration shear force cuts liquor flowing out from the dripper into drops, and drop pills are formed after the drops fall into the air-cooling circulation system and are cooled. An online monitoring apparatus is arranged on the dripper, and comprises a pulse signal emission mechanism with an emission frequency which is the same as a vibration frequency of the vibration apparatus. The control system controls and regulates a dropping parameter according to a monitoring result of the online monitoring apparatus. The present invention combines vibration dropping, online monitoring and controlling, air cooling, and fluidized drying and coating together, which satisfies the requirement of high-speed dropping, micro pill preparation and improving a drug-loading capacity. Thus, the drug-loading capacity of drop pills can be multiply improved, the usage of auxiliary materials and the dosage can be greatly reduced, organic solvent residual can be completely avoided, and requirements of different processes including slow-release coating, film coating and sugar coating can be satisfied.